IndraLab

Statements

MYO1 binds CALM1. 4 / 4
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reach
"Replacing serine 742 within the IQ neck region with a phosphomimetic aspartic acid residue had no significant impact upon the affinity, calcium sensitivity or cooperative nature of the interaction between Myo1 and Cam1 (Figure 2F)."
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"These relative protein levels, binding affinities and low Ca concentrations favor Cam1 binding to Myo1, over Cam2 at both IQ sites (Figure 8B), consistent with in vivo observations.Although Ca levels are low during vegetative growth, sporadic prolonged calcium bursts occur upon pheromone release during mating (Carbó et al., 2017; Iida et al., 1990), and levels elevate significantly (~10 fold) during the subsequent meiosis and sporulation (Suizu et al., 1995)."
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"Cam1 and Cam2 associate with Myo1 during meiosis."
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"Analysis of interactions between Cam1 and Myo1 –FRET revealed two distinct phases to the association of Cam1 molecules with the combined Myo1 motifs."
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