IndraLab

Statements


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"In mammals, the ancestral CEA gene family was composed of five genes, i.e. CEACAM1, CEA-CAM16, CEACAM18, CEACAM19 and CEACAM20."

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"Using sequences coding for extracellular domains (CEA-CAM16N1, A, B, N2, CEACAM18N, CEACAM19N) of orthologous CEACAMs we could identify all orthologous CEACAM genes in each species, except for M. lucifugus for which we did not find CEACAM16."

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"Cells were also transfected with mouse CEA-CAM1 and/or TLR2 siRNA for at least 24 hr before infections in other experiments (e and f)."

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"We have also Frontiers in Microbiology | Virology studied the relationship between MHV susceptibility and CEA-CAM1 allelic forms by using wild mice (Ohtsuka et al., 2001) ."

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"CEA-CAM1 is a transmembrane inhibitory receptor composed of one N-terminal immunoglobulin variable (IgV)-like (also called N domain) and three Ig constant (IgC)-like extracellular domains (also named A1, B, and A2 domains)."

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"However, lack of CEA-CAM1 limited the survival of CD8 + T cells after activation, as demonstrated by the finding that the number of transferred P14 × Ceacam1 -/-CD8 + T cells were significantly lower than those of the P14 × WT CD8 + T cells (Fig. 3b) ."

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"Furthermore, mouse hepatitis virus, which belongs to the corona viridae group 2 uses CEA-CAM1 as a cellular receptor to infect susceptible hosts [36, 37] ."

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"Recently, some CEA-CAM1 molecules deleting TM and Cy were found in intestinal epithelium and intestinal secretions, and those neutralize MHV (Terahara et al., 2009) ."

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"CEA-CAM1 belongs to an immunoglobulin (Ig) superfamily and is composed of an ectodomain, transmembrane domain (TM), and cytoplasmic tail (Cy)."