IndraLab

Statements

CALM1 binds KCNQ3. 4 / 6
2 | 4
reach
"These results indicated that SUMOylation of Kv7.2 and Kv7.3 specifically regulates their binding with CaM1.To verify the role of SUMOylation of Kv7.2 and Kv7.3 in their binding with CaM1, these plasmids were transfected with SUMO2, and the co-IP results showed that SUMO2 significantly enhanced the binding of both Kv7.2 and Kv7.3 with CaM1 (Fig. 4F)."
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"To further investigate the role of SUMOylation in the binding of Kv7.2 and Kv7.3 with CaM1, we detected whether loss of SUMOylation of Kv7.2 and Kv7.3 affects the interaction between Kv7.2 or Kv7.3 and CaM1."
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"Because SUMOylation regulates the interaction between Kv7.2 or Kv7.3 and CaM1, we asked whether retigabine regulates the interaction between Kv7.2 or Kv7.3 and CaM1."
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"Taken together, these results showed that SUMOylation plays a critical role in the interaction of Kv7.2 and Kv7.3 with CaM1 and the assembly of Kv7.2 and Kv7.3."
34509475