IndraLab

Statements

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"The CAM-integrin interaction produces a tight adhesion that will finally allow the immobilized leukocyte to transmigrate through the endothelial wall in a process of diapedesis [ 7 ]."
32598943
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"These experiences suggest that, at least in IBD, targeting the chemokine-chemokine receptor axis is not as effective as targeting integrin-CAM interactions."
32598943
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"Based on these novel integrin–CAM interactions, and the novel observation that L1 can be expressed on blood vessels under various pathogenic conditions, we propose that L1 may have an expanded and unexpected role in various vascular and thrombogenic processes."
9396761
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"cCAM integrin-binding active sites are given as amino acid motifs; residues also fought to participate in integrin- CAM interactions are shown in brackets. (Ref."
8796911
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"Subsequent adhesion and crawling are primarily mediated via the interactions between the members of CAM and β 1 /β 2 integrin families ( xref ), however the specificity of these interactions differs between neutrophils and monocytes ( xref – xref )."
21037096
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"Besides well-documented integrin–CAM involvement, this process depends first on rearrangement of lymphocyte's cytoskeleton, coordinated by GTPases RAP1 and RhoA and their multiple downstream effectors[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20685342
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"Finally, diapedesis is influenced by HS regarding transendothelial chemokine gradient formation and integrin- CAM interactions, and further enhanced by heparanase-mediated degradation of the endothelial basement membrane."
25692849
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"Natalizumab, a monoclonal humanized antibody targeting integrin α4, inhibits the transmigration of lymphocytes into the CNS by preventing the interaction of integrin α4β1 with V-CAM expressed on brain vascular endothelial cells."
37739811
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"Prior to integrin-CAM engagement, there is evidence in autoimmune and allograft transplant models that T cells require a cognate antigen signal, presented by MHC class I or MHC class II expressed on EC, to enter tissues ( xref , xref , xref – xref )."
30555479
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"This leads to the attraction of B cells to the walls of HEVs, allowing the adhesion of B cells to the endothelium via α4β1 integrins interacting with V-CAM1 ( xref )."
36936934
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"PF-00547659 (SHP647) is a fully human monoclonal IgG2κ antibody targeting MAdCAM-1, an intestinal endothelial CAM that binds α4β7 integrin on lymphocytes."
29740202
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"Jointly with motility assays (Fig.  xref ), this indicates that parasitised DCs utilise integrin and CAM interactions to adhere and perform TEM, which is potentiated by T. gondii infection."
34023934
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"The reduction of motility of DCs on endothelium suggests instead, arrest and adhesion, which is regulated by integrin–CAM crosstalk [ xref , xref ], and precedes leukocyte TEM (Fig.  xref d)."
34023934
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"The ratio of frequency shift under stimulation to that without stimulation indicated the number and strength of integrin-CAM binding stimulated by the chemokine."
23911626
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"Blocking the integrin-CAM interactions in the intestine is used as a strategy for IBD therapy aimed at reducing immune cell infiltration into the inflamed intestine."
33614645
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"Interestingly, disruption of the integrin–CAM interaction by blockade of β1 and β2 integrins, along with ICAM-1, partially restored the hypermotility of infected DCs on endothelium."
34023934
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"Jointly, this shows that, potentiated by T. gondii infection, integrin–CAM interactions mediated TEM."
34023934
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"Other integrin-CAM combinations, such as αMβ2/ICAM-1, as well as those mediated by VCAMs, MAdCAM, and ALCAMs also have diverse roles dependent on the tissue microenvironment ( xref )."
33777044
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"However, integrin–CAM interactions are likely to be in play, as shown here for T. gondii -infected DCs."
34023934
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"Interactions between integrins and CAM counter-receptors lead to firm adhesion, arrest, flattening, and migration of leukocytes across the endothelium ( Springer, 1994 )."
16442633
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"Future studies related to CAM-integrin interactions will be necessary to examine a variety of additional questions including that of which integrin binding ligands are generated with learning and memory in vivo."
26321910
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"Furthermore, the ΔPWV response of 8866 cells on MadCAM-coated sensors is blocked to completion by an α4-specific antibody, demonstrating that the ΔPWV signal is mediated by integrin–CAM interactions."
25158003
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"Given its penultimate role of leukocyte recruitment and migration, disrupting integrin:CAM signaling remains a key therapeutic strategy for the management of inflammatory disorders ( xref ; xref ; xref ; xref )."
32562668
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"Therapeutic strategies designed to limit pathogenic leukocyte paracellular migration across activated endoneurial endothelial barriers must therefore take into consideration the isoform specificity of localized leukocyte integrin:CAM interactions."
32562668
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"Taken together, these results demonstrate that the ΔPWV signal is a cell adhesion-mediated measurement governed by integrin–CAM interactions."
25158003
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"Despite exquisite diversity among integrin:CAM cell-cell interactions ( xref ), some progress has been made toward selective therapeutic application targeting integrin signaling."
32562668
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"These studies highlight anticipated differences in clinical responsiveness between central (BBB)- or peripheral (BNB)-targeted therapies and underscore the need to tailor therapeutic strategies towards leukocyte:endoneurial endothelial cell expressed integrin:CAM selective interactions."
32562668
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"A challenge which currently limits the clinical application of any new therapeutic strategy, including translatable nanotherapies that target integrin:CAM interactions, is the possibility of off-target effects."
32562668