IndraLab

Statements


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"As majority of the patients had normal LDH levels, CEA-CAM1 value facilitates a more precise prognostic prediction [60, 73] ."

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"One representative chromatogram is shown in Figure 2A . Three amino acids were identified in each cycle of automated Edman degradation of peak 9 on Figure 2A . These data could be assembled to three peptide sequences of VFYWYK, ETIYSN, and AIYWYR in CEA-CAM10."

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"Interestingly, CEA-CAM 5 is temporarily produced during fetal development until birth."

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"We then removed the following features that were flagged in >0.5% of cells in the CITE-seq dataset: CD269 (TNFRSF17), CD304 (NRP-1), CD66b (CEA-CAM8), CD80, and TCR Va24-Ja18."

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"In addition, Silencing CEA-CAM 6 by RNAs decreased tumor proliferation by 68% in pancreatic cancer xenograft mice compared to control siRNAs (f."

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"In vitro and in vivo studies on melanoma xenografts show that antibodies built to target the extracellular portion of CEACAM1 and to block the N-domain of CEACAM1 (MRG1, a murine IgG1 monoclonal antibody against human CEA-CAM1) did not influence the proliferation rate but facilitate melanoma cell elimination by T cells and have no agonistic effect."

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"These could not be explained by higher sensibility of the IL-33 KO mouse strain as the expression of the basic receptors described to be involved in the infectivity such as CEA-CAM [27] , TLR2 [22, 28] , and TLR3 [29] receptors were expressed at a comparable level in WT and IL-33 KO mice."

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"Pathogens thus exploit the normal physiological function of CEA-CAM1 which acts as an immune inhibitory receptor on leukocytes upon homotypic or heterotypic interactions for example with other CEACAM members [7, 12] ."

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"Fimbrial proteins of several strains of Escherichia coli and Salmonella bind to D-mannosyl residues on CEA, NCA and human C-CAM [49, 50] ."

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"Our scope, once again, is GPI anchored CEAs: CEA-CAM 6 and CEA-CAM 5, which is also known as CD66e ( xref )."

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"In vitro studies revealed the relation between CEACAM1 expression and melanoma cells behavior; increased expression of CEA-CAM1 in melanoma cell lines amplified the invading capacity of these cells; downregulation of CEACAM1 expression in melanoma cells decreased the expansion ability of cells."

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"These viruses gained the ability to grow in cell lines from numerous species not permissive to wild-type MHV through an acquired recognition of receptors other than CEA-CAM1."

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"In mammals, CEACAM families consist of a group of orthologous members (CEACAM16, CEACAM18, CEA-CAM19, CEACAM20) where counterparts can be clearly assigned in different species and a group of paralogous members which are most closely related to CEACAM1 within the same species [3] ."

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"The cellular receptor for MHV is a member of the carcinoembryonic antigen family of cell adhesion molecules (murine CEA-CAM1 a )."

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"CEA-CAM1 directly inhibits activated NK and T lymphocytes and this results in an increase of its expression in melanoma cells that survive an in vitro immune attack, which can further inhibit new immune cells [41, 42, 59, 60] ."

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"The mechanism of attachment involves up-regulation of expression of epithelial cell-surface receptors, including CEA-CAM1 and intercellular adhesion molecule-1 [5] ."

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"In melanoma, through homophilic interactions, CEA-CAM1 inhibits natural killer (NK) cell activity and effector functions (such as cytotoxicity and interferon gamma (IFN ) release) of tumor-infiltrating lymphocytes (TILs)."

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"This complex translocates to the nucleus and binds to CEA-CAM 6 gene promoter, elevating its expression ( xref )."

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"CEACAM1 promotes melanoma progression: CEACAM1 enhances migration and invasion of melanoma cells; CEA-CAM1 impairs the antitumor immune responses of NK and T cells."

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"Noting that many mammalian and avian species in addition to bats are susceptible to coronavirus infection, receptor proteins that include ACE2, APN and CEA-CAM1."

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"Cloning of cDNA to the largest mRNA for this protein revealed that full-length CEA-CAM1 has four Ig-like domains (Dveksler et al., 1991) , but a number of two-and four-domain versions of the molecule were later found to be expressed in mouse cells."

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"Boulton and Gray-Owen show convincingly that CEA-CAM1 ligation to Opa52 induces SHP-1 and SHP-2 to bind this receptor, and that binding is dependent on TCR activation (via ligation of CD3ε)."

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"Over-expression of a second CAM, carcinoembryonic antigen, is associated with colorectal tumors which have a high risk for metastasis development."

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"Liver metastatic colorectal cancer cells express high levels of various progenitor markers such as EpCAM, CD44, CD24, and CEA-CAM along with CDX1."

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"Increasing metastasis is through CEA-CAM 6 signaling induced SRC activity."

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"Other CEA-CAM targeting antibodies are MN-3, MN-14 and MN-15."

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"Indeed, clinical isolates of N. gonorrhoeae from male urethra and female genital tract often express Opa proteins which bind to CEA-CAM1 but not to CEACAM3 [20] ."

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"Recent studies evidenced the correlation between CEA-CAM1 expressions in melanoma cell lines and melanoma tissue with microphthalmia-associated transcription factor (MITF) [45] ."

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"Interestingly, CEA-CAM 1 is under expressed in CRC, breast cancer, prostate cancer and hepatoma ( xref )."

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"CEA-CAM 1 is tumor suppressing through decreasing cell proliferation and metastasis, while CEA-CAM-5 is tumor promoting through inhibiting colon cell differentiation, anoikis and apoptosis ( xref , xref )."

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"On the other hand, 70% of epithelial tumors over express CEA-CAM 6 rather than CEA-CAM 5 ( xref , xref , xref )."

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"Results of the experiment showed a progressive increase in CEA-CAM1 expression on melanoma cells that resisted the attack of infiltrating lymphocytes."

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"CEA-CAM 6 oncogenic activity is due to mediating metastasis and resisting apoptosis."