
IndraLab
Statements
sparser
"Herein, we propose a sandwich-type surface enhanced Raman scattering (SERS) immuno-nanosensor which is aimed for detecting and quantifying Carcinoembryonic antigen-related cell adhesion molecule 5 (CEA-CAM5), a protein involved in intercellular adhesion and signaling pathways that acts as a tumor marker in several types of cancer."
sparser
"These could not be explained by higher sensibility of the IL-33 KO mouse strain as the expression of the basic receptors described to be involved in the infectivity such as CEA-CAM [27] , TLR2 [22, 28] , and TLR3 [29] receptors were expressed at a comparable level in WT and IL-33 KO mice."
sparser
"In mammals, CEACAM families consist of a group of orthologous members (CEACAM16, CEACAM18, CEA-CAM19, CEACAM20) where counterparts can be clearly assigned in different species and a group of paralogous members which are most closely related to CEACAM1 within the same species [3] ."
sparser
"In vitro and in vivo studies on melanoma xenografts show that antibodies built to target the extracellular portion of CEACAM1 and to block the N-domain of CEACAM1 (MRG1, a murine IgG1 monoclonal antibody against human CEA-CAM1) did not influence the proliferation rate but facilitate melanoma cell elimination by T cells and have no agonistic effect."
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"In vitro studies revealed the relation between CEACAM1 expression and melanoma cells behavior; increased expression of CEA-CAM1 in melanoma cell lines amplified the invading capacity of these cells; downregulation of CEACAM1 expression in melanoma cells decreased the expansion ability of cells."