IndraLab

Statements

CALM1 binds CEACAM5. 35 / 35
| 35
sparser
"As majority of the patients had normal LDH levels, CEA-CAM1 value facilitates a more precise prognostic prediction [60, 73] ."
27642217
sparser
"One representative chromatogram is shown in Figure 2A . Three amino acids were identified in each cycle of automated Edman degradation of peak 9 on Figure 2A . These data could be assembled to three peptide sequences of VFYWYK, ETIYSN, and AIYWYR in CEA-CAM10."
15901639
sparser
"We then removed the following features that were flagged in >0.5% of cells in the CITE-seq dataset: CD269 (TNFRSF17), CD304 (NRP-1), CD66b (CEA-CAM8), CD80, and TCR Va24-Ja18."
33835024
sparser
"Herein, we propose a sandwich-type surface enhanced Raman scattering (SERS) immuno-nanosensor which is aimed for detecting and quantifying Carcinoembryonic antigen-related cell adhesion molecule 5 (CEA-CAM5), a protein involved in intercellular adhesion and signaling pathways that acts as a tumor marker in several types of cancer."
35231760
sparser
"These could not be explained by higher sensibility of the IL-33 KO mouse strain as the expression of the basic receptors described to be involved in the infectivity such as CEA-CAM [27] , TLR2 [22, 28] , and TLR3 [29] receptors were expressed at a comparable level in WT and IL-33 KO mice."
28607531
sparser
"Fimbrial proteins of several strains of Escherichia coli and Salmonella bind to D-mannosyl residues on CEA, NCA and human C-CAM [49, 50] ."
9330864
sparser
"These viruses gained the ability to grow in cell lines from numerous species not permissive to wild-type MHV through an acquired recognition of receptors other than CEA-CAM1."
16877062
sparser
"In mammals, CEACAM families consist of a group of orthologous members (CEACAM16, CEACAM18, CEA-CAM19, CEACAM20) where counterparts can be clearly assigned in different species and a group of paralogous members which are most closely related to CEACAM1 within the same species [3] ."
27852220
sparser
"CEA-CAM1 directly inhibits activated NK and T lymphocytes and this results in an increase of its expression in melanoma cells that survive an in vitro immune attack, which can further inhibit new immune cells [41, 42, 59, 60] ."
27642217
sparser
"This complex translocates to the nucleus and binds to CEA-CAM 6 gene promoter, elevating its expression ( xref )."
33344222
sparser
"CEACAM1 promotes melanoma progression: CEACAM1 enhances migration and invasion of melanoma cells; CEA-CAM1 impairs the antitumor immune responses of NK and T cells."
27642217
sparser
"Noting that many mammalian and avian species in addition to bats are susceptible to coronavirus infection, receptor proteins that include ACE2, APN and CEA-CAM1."
22958247
sparser
"Cloning of cDNA to the largest mRNA for this protein revealed that full-length CEA-CAM1 has four Ig-like domains (Dveksler et al., 1991) , but a number of two-and four-domain versions of the molecule were later found to be expressed in mouse cells."
16877062
sparser
"Boulton and Gray-Owen show convincingly that CEA-CAM1 ligation to Opa52 induces SHP-1 and SHP-2 to bind this receptor, and that binding is dependent on TCR activation (via ligation of CD3ε)."
11875456
sparser
"Liver metastatic colorectal cancer cells express high levels of various progenitor markers such as EpCAM, CD44, CD24, and CEA-CAM along with CDX1."
32670883
sparser
"Other CEA-CAM targeting antibodies are MN-3, MN-14 and MN-15."
33344222
sparser
"Interestingly, CEA-CAM 1 is under expressed in CRC, breast cancer, prostate cancer and hepatoma ( xref )."
33344222
sparser
"CEA-CAM 1 is tumor suppressing through decreasing cell proliferation and metastasis, while CEA-CAM-5 is tumor promoting through inhibiting colon cell differentiation, anoikis and apoptosis ( xref , xref )."
33344222
sparser
"Results of the experiment showed a progressive increase in CEA-CAM1 expression on melanoma cells that resisted the attack of infiltrating lymphocytes."
27642217
sparser
"CEA-CAM 6 oncogenic activity is due to mediating metastasis and resisting apoptosis."
33344222
sparser
"Interestingly, CEA-CAM 5 is temporarily produced during fetal development until birth."
33344222
sparser
"DC-SIGN can bind through carcinoembryonic antigen-related cell adhesion molecule 1 (CEA-CAM1) on neutrophil surface [ xref ] or ICAM-3 on T-lymphocytes [ xref ]."
36078205
sparser
"In addition, Silencing CEA-CAM 6 by RNAs decreased tumor proliferation by 68% in pancreatic cancer xenograft mice compared to control siRNAs (f."
33344222
sparser
"In vitro and in vivo studies on melanoma xenografts show that antibodies built to target the extracellular portion of CEACAM1 and to block the N-domain of CEACAM1 (MRG1, a murine IgG1 monoclonal antibody against human CEA-CAM1) did not influence the proliferation rate but facilitate melanoma cell elimination by T cells and have no agonistic effect."
27642217
sparser
"Pathogens thus exploit the normal physiological function of CEA-CAM1 which acts as an immune inhibitory receptor on leukocytes upon homotypic or heterotypic interactions for example with other CEACAM members [7, 12] ."
27852220
sparser
"Our scope, once again, is GPI anchored CEAs: CEA-CAM 6 and CEA-CAM 5, which is also known as CD66e ( xref )."
33344222
sparser
"In vitro studies revealed the relation between CEACAM1 expression and melanoma cells behavior; increased expression of CEA-CAM1 in melanoma cell lines amplified the invading capacity of these cells; downregulation of CEACAM1 expression in melanoma cells decreased the expansion ability of cells."
27642217
sparser
"The cellular receptor for MHV is a member of the carcinoembryonic antigen family of cell adhesion molecules (murine CEA-CAM1 a )."
11495812
sparser
"The mechanism of attachment involves up-regulation of expression of epithelial cell-surface receptors, including CEA-CAM1 and intercellular adhesion molecule-1 [5] ."
15942883
sparser
"In melanoma, through homophilic interactions, CEA-CAM1 inhibits natural killer (NK) cell activity and effector functions (such as cytotoxicity and interferon gamma (IFN ) release) of tumor-infiltrating lymphocytes (TILs)."
27642217
sparser
"Over-expression of a second CAM, carcinoembryonic antigen, is associated with colorectal tumors which have a high risk for metastasis development."
1680575
sparser
"Increasing metastasis is through CEA-CAM 6 signaling induced SRC activity."
33344222
sparser
"Indeed, clinical isolates of N. gonorrhoeae from male urethra and female genital tract often express Opa proteins which bind to CEA-CAM1 but not to CEACAM3 [20] ."
27852220
sparser
"Recent studies evidenced the correlation between CEA-CAM1 expressions in melanoma cell lines and melanoma tissue with microphthalmia-associated transcription factor (MITF) [45] ."
27642217
sparser
"On the other hand, 70% of epithelial tumors over express CEA-CAM 6 rather than CEA-CAM 5 ( xref , xref , xref )."
33344222