IndraLab

Statements

CALM1 inhibits CYP3A4. 6 / 6
| 6
sparser
"Since CAM inhibits CYP3A4, the coadministration of CAM with some drugs metabolised by CYP3A4 should be carefully done."
33014130
sparser
"Furthermore, the applicability of this assay for the determination of CYP3A4 inhibition in complex matrix mixtures was successfully demonstrated in an in vitro experiment in which CYP3A4 inhibition by known CAM (β-carotene, green tea, milk thistle and St."
23674377
sparser
"CAM inhibits cytochrome P450 3A4 (CYP3A4) which is involved in the hepatic metabolism of many drugs."
25729426
sparser
"Several in vitro studies determined whether CAM can inhibit CYP3A4, but these studies revealed contradictory results."
24392691
sparser
"Therefore, the aim was to validate and optimize an LC-MS/MS method for the adequate determination of CYP3A4 inhibition by CAM in human liver microsomes."
23674377
sparser
"However, validated LC-MS/MS methods to determine in vitro CYP3A4 inhibition in human liver microsomes are scarce and not optimized for evaluating CYP3A4 inhibition by CAM."
23674377