IndraLab

Statements

CALM1 inhibits CYP3A4. 10 / 10
| 10
sparser
"Several in vitro studies determined whether CAM can inhibit CYP3A4, but these studies revealed contradictory results."
24392691
sparser
"Furthermore, the applicability of this assay for the determination of CYP3A4 inhibition in complex matrix mixtures was successfully demonstrated in an in vitro experiment in which CYP3A4 inhibition by known CAM (β-carotene, green tea, milk thistle and St."
23674377
sparser
"CAM inhibits cytochrome P450 3A4 (CYP3A4) and organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3, which influence the drug plasma concentrations not metabolized by CYP3A4, while AZM shows no such effect xref , xref , xref ."
34584985
sparser
"Since CAM inhibits CYP3A4, the coadministration of CAM with some drugs metabolised by CYP3A4 should be carefully done."
33014130
sparser
"Therefore, the aim was to validate and optimize an LC-MS/MS method for the adequate determination of CYP3A4 inhibition by CAM in human liver microsomes."
23674377
sparser
"CAM inhibits cytochrome P450 3A4 (CYP3A4) which is involved in the hepatic metabolism of many drugs."
25729426
sparser
"CAM inhibits CYP3A4, one of the enzymes involved in theophylline metabolism [ 39 , 51–53 ], which may explain the mechanism of the theophylline-CAM interaction [ 54 ]."
34619548
sparser
"Therefore, it is recommended to combine multiple test systems and methods of quantification to confirm CYP3A4 inhibition by CAM."
23394826
sparser
"Besides inhibition of CYP3A4 by CAM, CAM can also induce this CYP enzyme by affecting the gene expression of CYP3A4."
23394826
sparser
"However, validated LC-MS/MS methods to determine in vitro CYP3A4 inhibition in human liver microsomes are scarce and not optimized for evaluating CYP3A4 inhibition by CAM."
23674377