IndraLab

Statements

CALM1 is acetylated. 10 / 10
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"Interestingly, as reported above, the acetylation of CALM 1 at its NH 2 -terminal (CALM 8) resulted in a complete loss of its inhibitory activity."
10960189
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"All CAM acetyltransferases share similar molecular strategies in acetylating CAM."
27271676
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"This may be due to the lower affinity of Myo1 for unmodified Cam1, which would bring about dissociation of the two proteins at lower concentrations of cellular calcium, despite the pCa of the interaction being unaffected by Cam1 acetylation, and therefore failure to associate with the membrane."
35100446
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"Using biochemical analysis of recombinant bacterially expressed amino‐terminally acetylated Cam1, we show this post‐translational modification impacts the helical structure and thermal stability of the Cam1 protein, enhancing its sensitivity to Ca 2+ and affinity for its major cellular binding partner, Myo1."
35100446
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"Cam1 amino‐terminal acetylation affects calmodulin organisation and dynamics in vivo ."
35100446
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"Using this reported protein, we have previously shown that two molecules of acetylated Cam1 associate with the Myo1 IQ12 ‐FRET protein in a calcium‐dependent manner [ xref ]."
35100446
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"In addition, interactions can also be measured in vitro by determining the degree of acetylation of CAM in bacterial lysates."
19303932
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"Following the initial acetylation, non-enzymatic transfer of the acetyl group onto the adjacent 1-hydroxyl group allows for a second CAT-catalysed acetylation at the 3-hydroxyl group producing a di-ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32687937
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"DoerflerlFEBS Letters 344 (1994) 251 254 [12,19] and expressed as percent conversion of chloramphenicol (CAM) to acetylated CAM forms during a 1 h incubation."
8187893
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"It is worth noting that the proportion of native yeast Cam1 that is acetylated on its amino‐terminus within the yeast cell (40%) [ xref ], generating a subpopulation of CaM with distinct biophysical properties, coincides precisely with the proportion of discrete Cam1 foci (40%) that associates with Myo1 in the fission yeast cell [ xref ]."
35100446