IndraLab

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"Ca ^-dependent binding of nitrendipine to calmo- dulin."

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"As summarized in Table I, dogfish erythrocyte D245 and mammalian brain a-fodrin are similar in that they ex- hibit comparable electrophoretic mobili- ties, comparable calcium dependent cal- modulin bi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1."

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"We demonstrated that KIF1Bbeta promotes mitochondrial fission by promoting CN dependent dephosphorylation of DRP1 on Ser637.KIF1Bbeta binds to the Ca 2+ sensor and adaptor protein CALM2, a key regulat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"When calmo- dulin binds calcium, it adopts a folded configuration that can then bind to target proteins such as calmo- dulin dependent protein kinase."

"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+–CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the E–F hands in each domain and dramatically changes the two domains of CaM to produce more ‘open’ conformations"

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"The calcium binding activity of calmodulin, which TABLE I THE EFFECT OF EDTA ON BINDING OF CALCIUM TO CALMODULIN Bound calcium Addition (pmol) Calmodulin 140 Calmodulin + EDTA 15 - 26 EDTA 23 Note."

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"The free calcium concentration at which calmo-dulin binds calcium ions is strongly influencedby the ionic environment and by the presence of target proteins."

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"It is speculated that the extract could prevent calcium influx, inhibit the calcium-in- duced calcium release mechanism, prevent the release of calcium from the sarcoplasmic reticu- lure or prevent th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Sasaki, T., Naka, M., Nakamura, F. and Tanaka, T. (1992) Ruthenium red inhibits the binding of calcium to cal- modulin required for enzyme activation."