IndraLab

Statements

CALM1 binds SVA. 13 / 13
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"Surgeons should consider obtaining global sagittal alignment radiographs in high-risk patients, particularly elderly individuals or those with evident postural abnormalities, as the CAM-SVA measurement provides valuable prognostic information that can inform patient counseling and surgical planning [ xref ]."
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"This study demonstrated that larger preoperative CAM-SVA values and advanced age independently predict KFC progression following TKA."
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"SVA-C7, SVA-C2, SVA-CAM were larger in males and high PI, and increased significantly after 50 years (Pr>0.9999)."
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"Univariate analysis identified advanced age, preoperative KFC, increased CAM-SVA, and increased SVA as significant predictors of KFC progression (all p < 0.01)."
41074097
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"This study was conducted to investigate whether preoperative global sagittal alignment parameters, particularly the center of the acoustic meatus-sagittal vertical axis (CAM-SVA), could predict short-term KFC progression after TKA."
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"In the multivariate logistic regression model (Table  xref ), only CAM-SVA (OR, 1.02; 95% CI 1.01–1.04; p < 0.05) and age (OR, 1.09; 95% CI 1.02–1.17; p < 0.01) remained as independent predictors."
41074097
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"Multivariate analysis revealed that CAM-SVA and age were independently associated with KFC progression (odds ratio: 1.02 [95% CI 1.01–1.04], p < 0.05; and 1.09 [95% CI 1.02–1.17], p < 0.01, respectively)."
41074097
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"This study identified CAM-SVA and age as independent predictors of KFC progression following TKA."
41074097
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"CAM-SVA and advanced age were identified as independent predictors of KFC progression following TKA, supporting the hypothesis that global sagittal malalignment contributes to compensatory knee flexion through biomechanical interdependence of the knee–hip–spine kinetic chain."
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"Each millimeter increase in CAM-SVA was associated with a 2% increased odds of progression, while each year of age conferred a 9% increased risk."
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"However, the present study's focus on CAM-SVA provides a more comprehensive assessment of global balance rather than isolated pelvic morphology."
41074097
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"Based on the biomechanical evidence supporting the interconnected nature of the knee–hip–spine kinetic chain and preliminary observations of compensatory mechanisms in sagittal plane deformities, it was hypothesized that patients with greater preoperative global sagittal malalignment, as measured by the center of the acoustic meatus-sagittal vertical axis (CAM-SVA), would demonstrate increased risk of KFC progression following TKA due to persistent compensatory biomechanical demands."
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"Patients with KFC progression exhibited significantly altered preoperative global sagittal alignment compared with those without progression, including greater CAM-SVA (51.3 ± 63.8 vs. 7.2 ± 43.9 mm, p < 0.01), greater SVA (74.4 ± 49.5 vs. 36.0 ± 41.1 mm, p < 0.01), and a larger standing knee flexion angle (16.4 ± 7.5 vs. 11.0 ± 7.4°, p < 0.01)."
41074097