IndraLab

"For example, activity of the core AJ components E-cadherin (E-cad) and α-catenin (α-cat) has been linked to activation of the core Hippo kinase LATS1/2 and inhibition of YAP ( xref ; xref ; xref ), and in Drosophila the Ig-CAM protein Echinoid that localizes to AJs can promote Salvador/Hpo activity to inhibit Yki ( xref )."

"The ultrastructure of CNS myelin requires specialized structural myelin proteins, including the transmembrane-tetraspan proteolipid protein (PLP) and the Ig-CAM myelin-associated glycoprotein (MAG)."

"Other members of the Ig-CAM family, such as the netrin receptor DCC, the Slit receptor Robo, and neural cell adhesion molecule (N-CAM), have dual roles."

"Like Ihog, other members of the Ig-CAM family, such as the netrin receptor DCC, the Slit receptor Robo, and neural cell adhesion molecule N-CAM, also have dual roles in adhesion and signaling ( xref ; xref )."

"Transmembrane protein P0 is an immunoglobulin-like cell adhesion molecule (Ig-CAM) and mediates the adhesion of the extracellular myelin surfaces. xref , xref , xref Periaxin is the second most abundant protein in PNS myelin and is a scaffolding protein. xref , xref , xref Periaxin is expressed before P0, MBP, or MAG and is suggested to play an important role during ensheathment and myelination in the PNS. xref In the CNS and PNS, MBP accounts for 8% of the myelin proteins and mediates the intracellular adhesion of cytoplasmic surfaces between individual layers of compact myelin. xref , xref , xref MBP is a highly heterogeneous protein as a result of alternative splicing and posttranslational modifications such as N-terminal acylation, GTP- and ADP-ribose binding sites, deamidation, methylated arginine, methionine sulfoxide, phosphorylation, and deimination of arginyl residues. xref , xref In the CNS of shiverer mutant mice, which do not express MBP, major dense lines are missing."

"Down syndrome cell adhesion molecule (DSCAM), a member of the immunoglobulin cell adhesion molecule (Ig-CAM) superfamily, is involved in developing the central and peripheral nervous system by influencing cell adhesion mechanisms necessary for synaptic activity and plasticity."

"They contain a furin-like cleavable domain and transmembrane domains, i.e., C-terminal TM-1 and cytoplasmic tail. (f) Membrane-type MMPs, including MMP-17 and MMP-25, resemble archetypal MMPs and contain a C-terminal glycosylphosphatidylinositol (GPI) membrane anchor. (g) Other MMPs (MMP-23A and MMP-23B) also resemble archetypal MMPs, lack a hemopexin domain and contain N-terminal TM-II and cytoplasmic C-terminal immunoglobulin-like cell adhesion molecule (Ig-CAM) domains [ xref , xref ]."

"Considering that quantification of the most abundant myelin proteins requires a high dynamic range ( xref ; xref ), we calculated the relative abundance of the 562 proteins identified in zebrafish myelin by MS E . According to this dataset, the most abundant zebrafish myelin proteins are myelin basic protein (MBPa), the Ig-CAM myelin protein zero (MPZa), the short-chain dehydrogenase 36K (also termed DHRS12), MPZb, and the complement inhibitor CD59, which respectively, constitute 7.6%, 7.3%, 6.3%, 4.7%, and 4.6% of the total myelin protein ( xref )."

"MMP-23 is an MMP that contains N-terminal transmembrane domain type II for anchoring the protein to the cell surface and C-terminal immunoglobulin-like cell adhesion molecule (Ig-CAM) domain ( xref ) to mediate protein–protein and protein–lipid interactions."

"This triggers the activation of integrins from the cancer cells allowing their firmer adhesion to members of the Ig‐CAM family such as ICAM and VCAM‐1, initiating the transendothelial migration and therefore the extravasation process. xref VCAM‐1 is therefore thought to play a key role in the process of malignant progression and its presence studied in terms of impact on cell migration. xref "

"The Ihog family proteins are type I single-span transmembrane proteins with immunoglobulin (Ig) and fibronectin type III (FNIII) domains, resembling typical cell adhesion molecules in the Ig-CAM (Ig cell adhesion molecule) superfamily."

"The Ig-containing and proline-rich receptor-1(IGPR-1) is a newly identified Ig-CAM that is uniquely expressed in human and other higher mammalians, but not in rodents [ xref ]."

"One group of lesions, accounting for 25% of all active lesions, was characterized by preferential loss of the periaxonal Ig-CAM MAG."

"By mass spectrometric quantification, the predominant Ig-CAM myelin protein zero (MPZ/P0), myelin basic protein (MBP), and the short-chain dehydrogenase 36K constitute 12%, 8%, and 6% of the total myelin protein, respectively."

"In addition, recent work in the spinal cord found that an Ig CAM complex of NB2 and Caspr4 on sensory neurons interacts with the L1 Ig family members NrCAM and CHL1 on GABApre interneurons to control synapse formation specifically at the axonal termini of sensory afferents ( xref )."

"Interactions Between Cindr and Ig-CAM Proteins."

"Indeed, the major bands of fish myelin were constituted by one or several splice isoforms of MBP, one or two variants of the Ig-CAM myelin protein zero (MPZ, previously termed intermediate proteins IP1 and IP2) and a protein migrating at the molecular weight of 36 kDa (termed 36K)."

"In this study, we revealed that IgSF11, a member of the Ig-CAM family, engages in homophilic interactions and leads to increased osteoclast differentiation through association with PSD-95."

"For example, dysregulation of Phgdh , Eno1 and Gapdh , three functionally linked glycolytic enzymes in module M3 suggests that lower levels of Blimp-1 are impacting on metabolic fitness and the acquisition of Ig-CAM adhesion molecules in M13 such as Icam1 , Bcam and Epcam argues for altered adhesive properties."

"The adhesion of endometrium fragments to the peritoneum in women with endometriosis is enhanced by the overproduction of cellular adhesion molecules that facilitate intercellular binding and cellular attachments with the extracellular matrix; including CD44 transmembrane glycoprotein, cell adhesion molecules (CAM) such as integrins, cadherins, selectins, the immunoglobulin superfamily (Ig-CAM), and transmembrane-anchored proteoglycans like syndecans [ xref , xref ]."

"One member, Gpr125, resembles immunoglobulin-like cell adhesion molecules (Ig-CAM) and has leucine-rich repeats (LRR) that are found in the axonal guidance factor, Slit1, and the hair follicle progenitor marker, LRIG xref , xref ."