IndraLab

Statements

CALM1 binds DSG3. 30 / 30
| 30
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
35528070
sparser
"Histopathological results suggested that the angiogenic response and re-epithelization potential in PVA-CAM were effectively higher than for uncapped-CAM."
35528070
sparser
"The main reason was the presence of surface coating or capping agents in PVA-CAM, which leads to a better healing capacity, an effective angiogenic response and complete fibroblast and collagen regeneration."
35528070
sparser
"Of all the optimized formulations being studied in these findings, PVA-CAM possess a predominant antimicrobial potential with an effective wound healing contraction of nearly 69% on the 3 rd day after the wounding process, in contrast with the uncapped-CAM with a value of 20%."
35528070
sparser
"Similarly on the 14 th day after excision wound injury, treatment with PVA-CAM showed an equal maximum regeneration of fibroblast and collagen and was significantly more effective and angiogenic compared with CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a moderate amount of collagen and fibroblast regeneration, with scant inflammation during their healing process."
35528070
sparser
"There is a consequent increase in the percentage wound contraction for PVA-CAM with a maximum amount of angiogenic response."
35528070
sparser
"A possible explanation is as follows: the percentage cumulative release of PVA-CAM is found to be a systematic and controlled release due to their less cytotoxic effects on blood cells, whereas the percentage cumulative release of uncapped-AgNPs is found to have a faster and sudden release profile due to the absence of a capping agent and their high toxicity to blood cells."
35528070
sparser
"Therefore, due to the lower toxicological effects, controlled release of silver ions and dominant antimicrobial efficacy against selective microorganism, we conclude that PVA-CAM can be considered a more effective polymer for therapeutic benefits in wound healing applications."
35528070
sparser
"These findings indicate that PVA-CAM have a predominant antibacterial activity and accelerate the healing potential of excision wound models in Wistar albino rats by enhancing angiogenesis in the wounded sections and are comparatively more efficient (among polymers) than uncapped-CAM, SBD-CAM or untreated wounds (the control)."
35528070
sparser
"The obtained histopathological results show the maximum development of collagen and fibroblast deposition when treated with PVA-CAM and these are relatively higher than for other AgNP formulations."
35528070
sparser
"Hence, the antimicrobial efficacy and wound contraction response observed in PVA-CAM was at a maximum rate."
35528070
sparser
"Also, PVA-AgNP impregnated CAM (PVA-CAM) shows positive effects through their anti-inflammatory and angiogenic properties, with a nearly 95% healing effect within 9 days."
35528070
sparser
"The complete development of collagen and fibroblast constituents was also monitored in PVA-CAM by hematoxylin & eosin (H & E) and Masson trichrome (MT) staining."
35528070
sparser
"Finally, PVA-AgNPs, PVP-AgNPs, TSC-AgNPs, uncapped-AgNPs and SBD-suspensions were incorporated into the formulated polymeric matrix to form PVA-AgNP impregnated CAM (PVA-CAM), PVP-AgNP impregnated CAM (PVP-CAM), TSC-AgNP impregnated CAM (TSC-CAM), uncapped-AgNP impregnated CAM (uncapped-CAM) and SBD-suspension impregnated CAM (SBD-CAM), respectively, and freeze dried for further analysis."
35528070
sparser
"Group I was treated as the control (no treatment), Group II was treated with CAM alone, Groups III, IV, V and VI were treated with uncapped-CAM, TSC-CAM, PVP-CAM and PVA-CAM, respectively."
35528070
sparser
"Treatment was given on predetermined days, in which the prepared matrix scaffolds were used as substrates for impregnation of AgNPs. xref The process includes the exposure of various synthesized scaffolds ( i.e. , CAM alone, uncapped-CAM, capped = TSC-CAM, PVP-CAM and PVA-CAM, SBD-CAM) which were allowed to react on alternate days with the wound area in order to initiate the inflammatory phase followed by the other phases."
35528070
sparser
"As shown in xref , wounds treated with PVA-CAM showed a greater percentage wound contraction compared to PVP-CAM, TSC-CAM, SBD-CAM, uncapped-CAM, CAM alone or the control group."
35528070
sparser
"From the results of xref , on the 3 rd day, the percentage wound contraction for PVA-CAM, PVP-CAM, TSC-CAM, SBD-CAM, uncapped-CAM, CAM alone and the control group was found to be 69.25%, 65.5%, 34.25%, 32.75%, 20.25%, 29.5% and 18.25%, respectively."
35528070
sparser
"Similarly, on the 6 th day, the percentage wound contraction for PVA-CAM, PVP-CAM, TSC-CAM, SBD-CAM, uncapped-CAM, CAM alone and the control group was found to be 81.75%, 78.5%, 44.25%, 37.75%, 31.5%, 35% and 28.25%, respectively."
35528070
sparser
"On the 9 th day, the percentage wound contraction for PVA-CAM, PVP-CAM, TSC-CAM, SBD-CAM, uncapped-CAM, CAM alone and the control group was found to be 95.25%, 90%, 85.25%, 77%, 60.75%, 64% and 55.25%, respectively."
35528070
sparser
"On the 14 th day, the percentage wound contraction for PVA-CAM, PVP-CAM, TSC-CAM, SBD-CAM, uncapped-CAM, CAM alone and the control group was found to be 99.5%, 95%, 88.5%, 84.5%, 70.75%, 72% and 68.75%, respectively."
35528070
sparser
"On the 20 th day, the percentage wound contraction for PVA-CAM, PVP-CAM, TSC-CAM, SBD-CAM, uncapped-CAM, CAM alone and the control group was found to be nearly 100%, 100%, 100%, 98.5%, 90.25%, 99.87% and 89.75%, respectively."
35528070
sparser
"Although the percentage wound contraction for PVP-CAM, TSC-CAM and SBD-CAM was quite a bit higher than for uncapped-CAM and the control group, wounds treated with PVA-CAM show the maximum significant wound contraction ( p ≤ 0.001) efficiency due to their biocompatibility with wound tissue."
35528070
sparser
"From xref , it is proven that the percentage wound contraction for uncapped-CAM was significantly lower than the values for SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on all the respective (3 rd , 6 th , 9 th , 14 th and 20 th ) days, which may be due to the absence of surface coating or capping agents in the uncapped-CAM, which are responsible for nanoparticle stability and healing potential."
35528070
sparser
"The results suggested that PVA-CAM has greater percentage wound contraction and shows a more significant difference (***) ( p ≤ 0.001) than the control group."
35528070
sparser
"The wound contraction efficiency for uncapped-CAM was also found to be comparatively lower (ns) ( p value > 0.05) than that for PVA-CAM, which may be due to the absence of capping agents in the uncapped-CAM for wound healing applications."
35528070
sparser
"Our results suggest that PVA-CAM reveals a faster recovery of healing and ends up with better proliferation of skin tissues and re-epithelization levels in the wound healing cascades."
35528070
sparser
"Histopathological analyses of the excision wound models in the control group (without treatment), CAM alone, uncapped-CAM, SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on the 9 th and 14 th day after the excision wound injury are depicted using H & E and MT staining in xref , xref and xref ."
35528070
sparser
"Histopathological studies on treatment with PVA-CAM in the excision wound model showed a maximum amount of fibroblast presence and collagen regeneration after the 9 th day of the healing process, which was found to be comparatively more effective than CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a minimal amount of fibroblast and collagen regeneration, with the presence of dense inflammation."
35528070
sparser
"Wound treatment with uncapped-CAM after the 9 th day of observation showed skin tissue with dense inflammation, an absence of fibroblast development and a very minimal amount of collagen regeneration, and was found to be comparatively less effective than CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM."
35528070