IndraLab

Statements


| 151

sparser
"Available evidence indicates that FAM-CAM exhibits moderate sensitivity and high specificity for delirium screening in adults."

sparser
"The agreement between the family member’s detection of delirium in the case vignette was moderate using the FAM-CAM (kappa = 0.44) and substantial using the Sour Seven (kappa = 0.75)."

sparser
"This included 78% and 92% of participants correctly classifying delirium in the provided case vignettes using the FAM-CAM and Sour Seven, respectively."

sparser
"In addition, the readability of the FAM-CAM (Flesch-Kinkaid reading level ~11 th grade) and the Sour Seven (Flesch-Kinkaid reading level ~12 th grade) are higher than the suggested grade six level."

sparser
"The FAM-CAM is concise and easy to use, making it appropriate for routine clinical practice, which might benefit early delirium detection and potentially foster delirium management."

sparser
"Efforts to improve the readability of the FAM-CAM and Sour Seven may improve family member’s understanding of the questionnaires and may improve their identification of disorganized thinking and altered level of consciousness."

sparser
"In previous studies, some of the trained interviewers using the CAM were not blinded to the FAM-CAM results and used the results of the FAM-CAM to score specific CAM items, such as acute change."

sparser
"These approaches likely increased agreement between the FAM-CAM and CAM ratings. xref "

sparser
"There are three existing tools that can be independently completed by family caregivers – the FAM-CAM, the informant Assessment of Geriatric Delirium (I-AGeD) and the Sour Seven. xref – xref A strength of the FAM-CAM is that it allows families to systematically report their observations of features of delirium, as well as to detail when the changes (i.e., whether or not the changes were acute or progressive) began and if they have been getting better or worse (items 8 to 11)."

sparser
"As for informant-based tools such as the Single Question in Delirium (SQiD) which asks ‘ Is this patient more confused than before ’, the FAM-CAM has the benefit of including information on additional features of delirium while not adding burden to the clinicians in the ED. xref The FAM-CAM may be especially helpful in cases when patients present with ‘confusion’ or altered mental status’ as the chief complain associated with the ED visit, common in our cohort, and in patients with dementia where confusion may be part of the patient’s baseline."

sparser
"By using the FAM-CAM rather than the SQiD, clinicians may choose to use only information on acute change or more detailed information in the setting of dementia or altered mental status."

sparser
"The sensitivity of delirium detection by ED providers may be as low as 20%, and other tools that have been examined, such as the modified Richmond Agitation Sedation Scale, have also demonstrated moderate to low sensitivity in the ED setting (70%; 95% CI: 48%; 85%), especially among patients with dementia (55%; 95% CI: 28%; 79%) and there is no family-member equivalent to augment clinician assessments. xref , xref Although the sensitivity and likelihood ratios of the FAM-CAM were modest, it shows promise in increasing delirium detection if supplemented to current systematic screening strategies suggested in best practice guidelines."

sparser
"Based on the LR+ of 3.4, adding the FAM-CAM as a screening tool would increase detection of delirium by 28% overall. xref In patients with dementia (LR+2.2), it would increase detection by 20%, and in patients without dementia (LR+5.6) it would increase detection by 35%."

sparser
"Although FAM-CAM screening would require approximately an hour of staff training and additional per-patient time to distribute the FAM-CAM to families and interpret the results, it is a relatively simple tool and interpretation is quick and straightforward since the FAM-CAM is designed for use by non-medically trained caregivers."

sparser
"The most impressive findings came from FCs identification of delirium using the FAM-CAM."
| PMC

sparser
"In this pre-test post-test quasi-experimental study, consecutive eligible family members of critically ill patients admitted to an ICU completed an ICU Family Education Delirium intervention in two parts: 1) six-minute video on ICU delirium (risk factors, prevention/management, symptoms, communication with the ICU care team), and 2) two case vignettes to practice detecting delirium using family-administered delirium detection questionnaires (Family Confusion Assessment Method [FAM-CAM] and Sour Seven)."

sparser
"More family members correctly detected delirium symptoms in case vignettes using the Sour Seven (92%) compared with the FAM-CAM (78%)."

sparser
"Minimal explanation of the instrument is required as the FAM-CAM measure includes instructions and examples to guide the caregiver."

sparser
"Our results represent the performance of the FAM-CAM without any additional instructions provided to the family when completing the instrument."

sparser
"In the ED we do not envision the FAM-CAM serving as a stand-alone test to screen for delirium."

sparser
"However, in at risk patients in the ED where delirium status was unclear it would be feasible for a nurse or physician to provide a copy of the FAM-CAM to caregivers to complete."

sparser
"Results from the FAM-CAM could then be used by clinicians to inform their own assessments for delirium and subsequent medical decision making."

sparser
"After watching the iFAM-ED video module, family members correctly classified delirium in 78% (95% CI, 69 to 85) and 92% (95% CI, 86 to 96) of the provided case vignettes using the FAM-CAM or Sour Seven, respectively."

sparser
"An additional benefit of the FAM-CAM is that it may empower caregivers to assess for delirium in family members outside the hospital and seeking medical care in a timely fashion."

sparser
"The strengths of this study include the “real world” setting in which the FAM-CAM was tested, maximizing translation of our findings into clinical settings."

sparser
"We over-enrolled patients with a history of dementia allowing us to compare the validity of the FAM-CAM in this group that is clinically challenging and where family assessments may be particularly useful."

sparser
"In an ED sample that included patients with and without dementia, the FAM-CAM was found to have the potential to aid in the identification of patients with delirium."

sparser
"xref presents the FAM-CAM data in relation to the CAM data for the overall sample, xref , for patients with dementia and xref for patients without dementia."

sparser
"Dans cette étude quasi expérimentale avant après, les membres éligibles consécutifs de familles de patients en état critique admis dans une USI ont pris part à une formation familiale sur le delirium à deux volets : 1) le visionnement d’une vidéo de six minutes sur le delirium à l’USI (facteurs de risque, prévention/prise en charge, symptômes, communication avec l’équipe de soins de l’USI), et 2) deux vignettes pour pratiquer le dépistage du delirium à l’aide de questionnaires de dépistage du delirium administrés par la famille (Méthode d’évaluation de la confusion par la famille [FAM-CAM] et Questionnaire de dépistage du delirium ‘ Sour Seven ’)."

sparser
"Un nombre plus élevé de membres des familles est parvenu à dépister correctement les symptômes de delirium dans les vignettes à l’aide du questionnaire Sour Seven (92 %) comparativement au FAM-CAM (78 %)."

sparser
"In this issue of CCM, Fiest et at [ref] present results from a diagnostic accuracy study in which they test two family administered delirium screening tools, the Family Confusion Assessment Method (FAM-CAM) ( xref ), and the Sour Seven ( xref ) against the diagnosis of delirium according to the Diagnosis and Statistical Manual of Mental Disorders, Edition 5 (DSM-5)."

sparser
"The FAM-CAM and the Sour Seven demonstrated high sensitivity and specificity outside of the ICU, but neither had been validated among critically ill patients."

sparser
"For this study, the research team facilitated the FAM-CAM and the Sour Seven, which were filled out by the family member."

sparser
"Nevertheless, while many readers will conclude that the FAM-CAM and Sour Seven perform poorly among critically ill patients and therefore shouldn’t be used, this is overly simplistic."

sparser
"The results showed that among the patient family dyads in this study, both the FAM-CAM and Sour Seven alone had lower diagnostic accuracy (area under the curve [AUC] ≥65%) compared to ICDSC or CAM-ICU (AUC ≥77%)."

sparser
"Fiest et al also assessed the accuracy of the FAM-CAM and Sour Seven when these were added to the CAM-ICU and ICDSC, and found that the combined performance was not statistically different in most comparisons to the CAM-ICU or ICDSC alone, and worse in one."

sparser
"The reader should conclude from this study that, at this time, the family administered delirium screening tools FAM-CAM and Sour Seven should not replace intensivist administered CAM-ICU or ICDSC."

sparser
"Family members in the intervention group will also be provided with preoperative education on delirium and training in the Family Confusion Assessment Method (FAM-CAM) instrument 20."

sparser
"For participants randomized to the family-based system, family members (or caretakers) will receive preoperative education on delirium (including an educational video), a folder with an informational flyer and therapeutic activities checklists, and FAM-CAM training."

sparser
"Exploratory outcomes will include the incidence of positive FAM-CAM assessments (%) 30 days post-discharge, PROMIS Cognitive Function Abilities (Short Form 4a), 36-Item Short Form Survey, and 30-day readmission rates."

sparser
"While Fiest et al demonstrated that the test characteristics perform less well by AUC—involving a balance of sensitivity and specificity—which is true, both the FAM-CAM and the Sour Seven may still have a role, and certainly deserve further study."

sparser
"The fact that the FAM-CAM performed with 77% specificity (compared to 83% specificity for the CAM-ICU) suggests that within the ICU setting, family proxies using this screening tool have a capacity to identify acute delirium that approaches that of experienced and trained providers."

sparser
"Future studies could explore whether family education on delirium risk factors, diagnosis and management influence the test characteristics of the FAM-CAM and Sour Seven."

sparser
"In summary, Fiest et al are to be commended on performing a sizable study among critically ill patients to assess the test characteristics of two novel family administered delirium screening tools, the FAM-CAM and Sour Seven."

sparser
"The FAMCAM (family confusion assessment method to identify delirium) intervention was intended to educate family members in recognising delirium."

sparser
"For family-based interventions, the following measures will be reported: cumulative time family members spent with patients, proportion of daily tasks (e.g., assistance with glasses/hearing aids, handwashing), successfully completed, length of time spent on stimulating activity, and overall agreement of the FAM-CAM with interview-rated CAM assessments."

sparser
"For those enrolled in the intervention bundle, family members (or caretakers) will perform the FAM-CAM 20 independently of the research team."

sparser
"FAM-CAM assessments will be requested once daily in the afternoon."

sparser
"Cohen’s kappa will be used to assess agreement between research-based CAM delirium assessments and FAM-CAM assessments."

sparser
"Similarly, missing CAM and FAM-CAM data are expected as well."

sparser
"Reasons for missing assessments will be presented in conjunction with barriers that family members and caretakers report for conducting FAM-CAM assessments."

sparser
"Additionally, while family members will receive basic training and education on FAM-CAM administration, they will not receive rigorous training for assessing reliability or accuracy."

sparser
"Other CAM instruments are based on patient observation, e.g. nursing home CAM (NH-CAM) or caregiver interview, e.g. family CAM (FAM-CAM) [ xref , xref ]."

sparser
"There is a family version of CAM (FAM-CAM) [ xref ], but it requires a longer administration time than Sour Seven."

sparser
"Moreover, prior research reported better sensitivity of Sour Seven than FAM-CAM (72.9% vs 54.1%) and reported that family caregivers preferred Sour Seven over FAM-CAM [ xref ]."

sparser
"For example, the Family Confusion Assessment Method (FAM-CAM; xref ) could be used as a universal tool to achieve a language consensus among ADSC staff, FCPs, and PCPs."

sparser
"The CAM was initially designed for evaluating an acute confusion state, called delirium, among older hospitalized patients to decrease their morbidity and mortality, and then the FAM-CAM was further developed to be less time intensive and more user-friendly, which could be administered to FCPs either in person, by telephone, or electronically based on their observations ( xref )."

sparser
"ADSC staff spend a significant amount of time with their clients, and the FAM-CAM may be a comprehensive evaluation tool for cognitive functioning based on their consistent daily observations."

sparser
"The implementation of standardized assessment tools that enable providers across these settings to exchange information in a shared language (e.g., FAM-CAM) would also facilitate collaboration, integrated care, and earlier detection of acute illness."

sparser
"We excluded 85/147 dyads that did not provide data suitable to conduct pairwise Bayesian estimates (i.e., dyads that did not have the CAM-ICU, FAM-CAM and Sour Seven all recorded within 6-hours of the ICDSC)."

sparser
"Family delirium assessments using the FAM-CAM and Sour Seven which were done by the same family member at the same time, demonstrated more consistent results than clinical assessments."

sparser
"Twenty-eight patients (38.4%) were classified “without delirium” and 23 patients (31.5%) were classified “with delirium” by both the FAM-CAM and Sour Seven conducted within a 6-hour window."

sparser
"Sensitivity of the FAM-CAM and Sour Seven were 0.79 (95% CI 0.58–0.93) and 0.67 (95% CI 0.45–0.84), respectively."

sparser
"Specificity estimates were 0.63 (95% CI 0.48–0.77) and 0.69 (95% CI 0.55–0.83) for the FAM-CAM and Sour Seven, respectively."

sparser
"Positive predictive values (FAM-CAM, 0.51 [95% CI 0.34–0.68]; Sour Seven, 0.53 [95% CI 0.33–0.70]) were lower than negative predictive values (FAM-CAM, 0.86 [95% CI 0.71–0.96]; Sour Seven, 0.81 [95% CI 0.66–0.91])."

sparser
"In combining results from family delirium assessments, the FAM-CAM had higher sensitivity and specificity compared to the Sour Seven."

sparser
"We aimed to examine the diagnostic accuracy of the Family Confusion Assessment Method (FAM-CAM) for delirium detection."

sparser
"Sensitivity estimates were 0.83 (95% BC 0.73–0.92) and 0.64 (95% BC 0.47–0.82) and specificity estimates were 0.93 (95% BC 0.84–0.98) and 0.85 (95% BC 0.67–0.99) for the FAM-CAM and Sour Seven, respectively."

sparser
"In the present study we found that combining results from family assessments had higher sensitivity and specificity compared to either the FAM-CAM or Sour Seven used alone, which were also higher compared to estimates reported from our earlier diagnostic accuracy study in this sample [ xref ]."

sparser
"Future research should map items across the FAM-CAM and Sour Seven to create a single, family tool with maximized sensitivity and specificity and validate this tool in a large sample of patients."

sparser
"Since family members are critical to knowing a patient’s baseline status, which is the key to detecting acute changes in cognitive function [ xref ], the family CAM (FAM-CAM) [ xref ] has been created."

sparser
"FAM-CAM data in relation to CAM data is presented in xref for the overall sample and xref and xref respectively for patients with and without dementia."

sparser
"The Family Confusion Assessment Method (FAM-CAM) is a vital tool for assisting family members in identifying delirium; however, no study has yet been reported on the Chinese version of the scale."

sparser
"The objective of this study was to translate the FAM-CAM into a Chinese version and to verify its effectiveness for delirium detection in an online patient visit setting."

sparser
"The FAM-CAM was translated to Chinese according to the International Society for Pharmacoeconomics and Outcomes Research guidelines."

sparser
"Family members then used the Chinese version of the FAM-CAM to assess for delirium via online visitation, and ICU nurses assessed patients for delirium using the Intensive Care Delirium Screening Checklist (ICDSC)."

sparser
"The Cohen's kappa coefficient between the Intensive Care Delirium Screening Checklist and FAM-CAM was 0.759 (P < 0.01)."

sparser
"The sensitivity of the Chinese version of the FAM-CAM was 0.880, specificity was 0.890, positive predictive value was 0.928, negative predictive value was 0.823, and area under the receiver operating characteristic curve was 0.881 (95% confidence interval: 0.872-0.935, P < 0.01)."

sparser
"The Chinese version of the FAM-CAM was shown to effectively help families detect delirium and was suggested as a crucial tool for assisting ICU nurses in the early identification of delirium."

sparser
"The FAM-CAM had moderate sensitivity (57%; 95% confidence interval [CI]: 39% - 74%), but higher specificity (83%; 95% CI: 75% - 92%), when compared to the reference standard CAM, and acceptable NPV (83%) ( xref )."

sparser
"The majority of the false negatives (n=9 out of 13, 69%) were due to caregivers not identifying inattention on the FAM-CAM."

sparser
"Again, the majority of false negatives in patients with dementia (n=6 out of 9, 67%) were due to the caregiver not identifying inattention on the FAM-CAM."

sparser
"After discharge, a standardized icon called Family Confusion Assessment Method (FAM-CAM) was used to assess the patient’s representation cognitive function."

sparser
"In this study, the FAM-CAM had an overall sensitivity of 57% and specificity of 82% for delirium."

sparser
"We compared clinical outcomes in the 6-months after enrollment by FAM-CAM status."

sparser
"Preoperative education on recognizing delirium symptoms prepares family members to identify postoperative delirium and reduces caregiver distress. xref , xref The Family Confusion Assessment Method (FAM-CAM) xref is an adaptation of the Confusion Assessment Method (CAM), xref a widely-used delirium screening tool."

sparser
"The FAM-CAM utilizes family members to quickly identify delirium, and has high sensitivity in hospitalized older adults. xref In addition to detecting delirium, family members can also reduce delirium risk and duration."

sparser
"ED visits and mortality rates within 6 months were significantly higher among patients who screened positive on the FAM-CAM than in those who screened negative (hospital admission: 40% vs. 18%; mortality: 13% vs. 3%; ps<0.05, xref )."

sparser
"The patient's visual cognitive abilities were tested after they were released from the hospital by utilising a standardised icon known as the Family Confusion Assessment Method (FAM-CAM)."

sparser
"First, there is a potential bias as one of the authors (S.K.I.) is a creator or co-creator of four delirium identification instruments found in our review [CAM, Chart Delirium Identification (CHART-DEL), Family-Confusion Assessment Method (FAM-CAM), and 3-Minute Diagnostic Assessment (3D-CAM)]."

sparser
"The Family-CAM (FAM-CAM) was developed to provide a method for informant-based assessment of delirium."

sparser
"Validated against the CAM, the FAM-CAM had a sensitivity of 86% and a specificity of 98% ( xref )."

sparser
"However, in a recent study of 108 patients, 28% with delirium and 54% with dementia, the FAM-CAM demonstrated moderate sensitivity of 57% and a specificity of 83%."

sparser
"The majority of false negatives resulted from lack of caregiver identification of inattention when using the FAM-CAM ( xref )."

sparser
"One drawback of the FAM-CAM is that it requires subsequent confirmation with a formal delirium rating, however, the use of systematic caregiver observations to detect acute changes over time, and to augment other delirium instruments may aid significantly in accurately diagnosing DSD."

sparser
"As delirium symptoms often fluctuate and may be missed on a single assessment, the daily 3-step assessment is augmented by the FAM-CAM completed at initial screening, baseline, and weekly during the randomized treatment phase."

sparser
"Information collected via the FAM-CAM helps to inform the CAM rater’s understanding of the patient’s overall clinical presentation over time and bolsters the assessment of acute change."

sparser
"Further development of caregiver rating instruments like the FAM-CAM that provide a detailed description of the baseline characteristics of a patient with moderate or severe dementia will greatly improve detection and discrimination of an episode of delirium from a patient’s baseline fluctuation of symptoms."

sparser
"Delirium instruments, including the 4-DSD, UB-CAM, CAM, FAM-CAM, 6-CIT and 4AT, can aid in diagnosis, and each approach has its advantages and limitations."

sparser
"However, only the Family Confusion Assessment Method (FAM-CAM) ( xref ) and Sour Seven Questionnaire ( xref ) have been validated for use in ICUD assessment, with the latter proving superior in assessing delirium ( xref )."

sparser
"A validated chart review method was used to identify delirium, 26 and the study measures used to characterize cognitive function, such as the FAM-CAM, Short Blessed Test, and PROMIS assessments, are validated measures that increase confidence in the results."
| DOI

sparser
"While this is true, it is unclear whether this benefit is great enough to outweigh the increased complexity of incorporating the FAM-CAM into the evaluation of delirium in the chaotic ED-setting."

sparser
"CAM is the most widely used delirium detection instrument, and it has been adapted for the ED xref and for family corroboration xref (FAM-CAM)."

sparser
"If the FAM-CAM is to serve as an adjunct to existing ED delirium monitoring, the first step is to determine the optimal way to monitor delirium in busy clinical environments such as the ED, balancing diagnostic accuracy and efficiency."

sparser
"While the FAM-CAM could potentially serve as an adjunct to existing ED delirium monitoring programs, additional research is needed."

sparser
"No patients in the study population were found to have post-operative delirium 24–48 h after their procedure based on the FAM-CAM screening tool."

sparser
"This study found an incidence of delirium to be 1.4% (2 of 141 patients) three to 5 days after surgery using the FAM-CAM tool."

sparser
"While a larger sample size would significantly improve the power of the study, this was not possible due to (1); a high proportion of patient-carer pairs not providing consent, and (2); factors which did not allow for the FAM-CAM interview to be administered 24–48 h pre and post procedure (i.e. procedures being brought forward)."

sparser
"However, two tools already exist for the use by lay persons: The Informant Assessment of Geriatric Delirium ( I-AGeD) and the Family Confusion Assessment Method (FAM-CAM) [ xref , xref ]."

sparser
"The FAM-CAM does not contain any lay terms and requires previous training for the application [ xref ]."

sparser
"Among patients who were still alive and available to complete survey materials, nearly 25% of patients (4/17) scored positive for delirium based on family assessment (FAM-CAM), and all of these patients were delirious during hospitalisation."

sparser
"Of note, three of these five patients also screened positive for delirium based on the FAM-CAM."

sparser
"A validated, standardised chart review method was used to identify delirium xref and the study measures used to characterise cognitive function, such as the FAM-CAM, Short Blessed Test and PROMIS assessments, are standard measures that increase confidence in the results."

sparser
"These diagnostic test characteristics are lower than a prior study which trained family members on the FAM-CAM (88% sensitive and 98% specific). xref Mailhot et al did not provide such training to better simulate how the tool would be used in the ED setting."

sparser
"The authors acknowledge that without caregiver training, the sensitivity and specificity of the FAM-CAM are modest, and it should not serve as a stand-alone test for ED delirium."

sparser
"What advantages does the FAM-CAM have over simpler informant-based delirium assessments, such as the Single Question in Delirium (SQiD)?"

sparser
"Participants’ knowledge of the intervention and post-surgical management was tested via Knowledge Expectations of significant others (KEso) and Received Knowledge of significant others (RKso) [ xref ]; confusion assessment method (CAM) and family version (FAM-CAM) [ xref ] were used to measure empowering by knowledge."

sparser
"The SQiD asks, “Do you think [name of patient] has been more confused lately?” and has comparable diagnostic test characteristics (77% sensitive and 88% specific for ED delirium). xref Mailhot et al note that one of the benefits of the FAM-CAM over the SQiD is that the FAM-CAM provides information on all 4 domains of delirium, whereas the SQiD only provides information on the first feature in delirium, namely an acute change in cognition."

sparser
"Recent studies showed that administering two family-administered delirium detection tools (Family Confusion Assessment Method [FAM-CAM] and Sour Seven) among critically ill patients is feasible but has fair but lower diagnostic accuracy than clinical assessments using the Intensive Care Unit Delirium Screening Checklist (ICDSC) and Confusion Assessment Method for the ICU (CAM-ICU). xref Nevertheless, perspectives and expectations of family members and the ICU team on delirium detection by the family have not been explored."

sparser
"These studies should explore whether providing education on the FAM-CAM and Sour Seven improves a family member’s confidence and ability to detect delirium using these family-administered tools."

sparser
"Two tools for family caregivers to detect delirium have been validated and deemed feasible to employ in ICU populations: the Family Confusion Assessment Method (FAM-CAM) and Sour Seven [ xref ]."

sparser
"To examine the ability of the family-rated Family-Confusion Assessment Method (FAM-CAM) to identify delirium in the Emergency Department (ED) among patients with and without dementia, as compared to the reference-standard Confusion Assessment Method (CAM)."

sparser
"The caregiver self-administered the FAM-CAM."

sparser
"While FAM-CAM enables family caregiver assessments, professional verification remains essential [ xref ]."

sparser
"For concurrent validity, performance of the FAM-CAM was compared to the CAM."

sparser
"Thus, integrating telemedicine with FAM-CAM offers a key direction for real-time evaluation and intervention in home-based delirium management."

sparser
"For predictive validity, clinical outcomes (ED visits, hospitalization and mortality) over 6-months were compared in FAM-CAM positive and negative patients controlling for age, sex, comorbidity and cognitive status."

sparser
"The FAM-CAM had a specificity of 83% and NPV of 83%."

sparser
"Among patients with and without dementia, the FAM-CAM shows qualities that are important in the ED setting for identification of delirium."

sparser
"Using the FAM-CAM as part of a systematic screening strategy for the ED in which families’ assessments could supplement health care professionals’ assessments, is promising."

sparser
"The FAM-CAM xref is an informant-based delirium assessment that may help EDs overcome the barriers to delirium screening by sharing the workload of screening with a caregiver, when available."

sparser
"The FAM-CAM consists of 11 items that characterize changes in attention, speech, arousal, and orientation and is completed by a patient’s family member or caregiver who knows the patient’s baseline mental and cognitive status well."

sparser
"In this issue of the Journal of the American Geriatric Society , Mailhot et al xref report on their study evaluating the FAM-CAM in the ED, enrolling 108 patient-caregiver dyads, of whom 55 patients had pre-existing dementia."

sparser
"In contrast, both the Steis and Martins teams offered intensive training for family caregivers that would not be practical in an ED setting. xref , xref In the Bull study, family caregivers were trained in the three weeks before their family member’s elective surgery, to increase their knowledge of delirium and the use of the FAM-CAM. xref Another important distinction between our study and the previous validations of the FAM-CAM was our double blinding of ratings of caregivers and research staff."

sparser
"Family caregivers completed the FAM-CAM assessment which was compared to a reference standard, the CAM completed by a trained interviewer."

sparser
"The majority of the false negatives (n=9 out of 13, 69%) were due to caregivers not identifying the inattention criteria for delirium on the FAM-CAM."

sparser
"In adjusted models, a hospitalization in the following 6-months was more than 3 times as likely in FAM-CAM positive compared to negative patients (OR=3.4, 95% CI=1.2, 9.3)."

sparser
"The Confusion Assessment Method (CAM) is the most widely used standardized method for the identification of delirium with high sensitivity (94–100%) and specificity (90–95%). xref A version of the CAM for family members and informal caregivers, the Family Confusion Assessment Method (FAM-CAM), has been validated in outpatient and medical inpatient settings. xref , xref The FAM-CAM is completed by family caregivers with the goal of guiding them through describing their observations on the key symptoms of delirium."

sparser
"The FAM-CAM is not meant to take the place of the clinical providers’ assessment, but rather as an adjunct tool, to educate family members in the recognition of delirium."

sparser
"The FAM-CAM may help ED providers recognize delirium and could be used in conjunction with clinician’s delirium screening because the FAM-CAM obtains standardized information from family members who are often an untapped source of information."

sparser
"Among patients with dementia, the FAM-CAM showed higher sensitivity (with dementia, 61%; 95% CI: 41 % - 81% versus without dementia, 43%; 95% CI: 6% - 80%) and lower specificity (with dementia, 74%; 95% CI: 60% - 89% versus without dementia, 91%; 95% CI: 82% - 99%; xref ) and lower LR+ (with dementia 2.2; 95% CI: 0.7 – 3.6 versus without dementia 5.6 95% CI: −1.1, - 12.3)."

sparser
"The aim of this study was to examine the performance of the family-rated FAM-CAM in the ED compared to the reference standard CAM rated by trained research interviewers and to determine whether the FAM-CAM performed similarly in patients with and without dementia."

sparser
"The secondary aim was to examine whether delirium identified by the FAM-CAM is associated with clinical outcomes over 6-months (ED readmission, hospitalization and mortality), as evidence of its predictive validity."

sparser
"Validation of the FAM-CAM."

sparser
"In adjusted models controlling for age, sex, IQCODE, Emergency Severity Index at triage, and Charlson score, patients who had a hospitalization over the next 6 months were more than three times as likely to have had a positive FAM-CAM score than those who did not have a hospitalization (OR = 3.24, 95% CI = 1.2, 8.9) ( xref )."

sparser
"Patients who returned to the ED at 6 months were also more likely to have had a positive FAM-CAM score than those who did not (OR= 1.11, 95% CI = 0.4, 2.8)."

sparser
"Family members of older patients in the ED were able to systematically complete a delirium screening tool, the FAM-CAM, independently, without an education session or support from research staff, and correctly rule out delirium in the majority of patients (NPV= 83%)."

sparser
"Inattention, which is easily measured at the bedside, was identified as a symptom of delirium that family members have difficulty identifying and was responsible for 66% of family members’ missed cases of delirium. xref In addition, the sensitivity of the FAM-CAM was higher in patients with dementia compared to those without dementia, highlighting the ability of family members to detect delirium manifestations (e.g., acute change) in a population that is challenging to assess in the ED."

sparser
"Although never in an ED setting, the validity of the FAM-CAM has been previously assessed in three studies with varying results."

sparser
"Among older persons with pre-existing cognitive impairment, Steis et al reported high sensitivity (88%, 95% CI: 47–99) and specificity (98%, 95% CI: 86–100) of the FAM-CAM against the CAM. xref Similarly, among hospitalised older patients, Martins et al used the Portuguese version of the FAM-CAM and also observed high sensitivity (91%, 95% CI:74–97) and specificity (91%, 95% CI:74–97) against the CAM and against the DSM-IV-TR criteria (sensitivity: 75%, 95% CI:35–95; specificity: 86%, 95% CI:42–99). xref Finally, in a study conducted by Bull et al among post-knee or hip surgery patients, a Kappa of 0.47 was observed between the FAM-CAM and the CAM. xref The current study differs from these previous studies in several ways, in particular with regards to the training of family caregivers who completed the FAM-CAM and the blinding of assessors."

sparser
"In the current study, we did not provide any training to family caregivers, since we aimed to test the validity of the FAM-CAM under conditions that would increase the applicability of the results to real-world ED settings."