IndraLab

Statements


CALM1 inhibits CXCL8. 6 / 6
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"A recent study reported that TNF-alpha-induced IL-8 gene transcription was inhibited by CAM via repressing promoter activity in an AP-1 binding site, but not in a NF-kappaB-like site [20]."

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"Inhibition of IL-8 by CAM has been shown to be temporary with levels increasing thereafter, to decrease again later to basal pre-inflammatory levels [ xref ]."

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"CAM inhibited TLR agonist induced production of IL-6 and IL-8."

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"On the other hand, LPSinduced IL-8 production by human monocytes is suppressed by CAM through NF-␬ B and AP-1.19 Although it can not be denied that CAM affects activation of AP-1, those findings suggest that the transcriptional factors responsible for the expression of IL-8 vary with the stimulants and the cells chosen for the experiment.CONCLUSION The present study demonstrates that expression ofboth IL-8 protein and mRNA in adenoidal fibroblasts is induced by HIE and IL-1 ␤."

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"RSV infection of hTERT-HNECs, BEAS-2B, and A549 cells led to significant induction of IL-8, IL-6, and CCL5, all of which were suppressed by CAM."

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"As CAM and erythromycin have been reported to reduce neutrophil production of IL-8 [8], we hypothesized that inhibition of in vivo angiogenesis was probably due to a reduction in angiogenesis inducing[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"