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CALM1 binds RYR2. 18 / 18
2 | 3 13
biogrid
No evidence text available
23040497
sparser
"CAM is constitutively associated with the RYR2 either as apoCAM at low Ca 2+ (<100 nM) or as CaCAM at higher Ca 2+ (∼1 μM) [80,116,136] ."
16765984
sparser
"These six LR interactions, namely APOE-SORL1, APOE-LRP1, CALM1-CACNA1C, CALM1-RYR2, CALM3-CACNA1C, and CALM3-RYR2 (Fig.  xref c, d), consistently exhibited downregulation patterns in AD in comparative intercellular communication analysis."
38167548
sparser
"CALM1 encodes a regulatory protein of RYR2 and is responsible for inhibiting Ca 2+ release from RYR2 in the sarcoplasmic reticulum to maintain a normal contraction‐relaxation cycle. xref Oxidative stress impairs binding of CALM1 to RYR2 , causing aberrant Ca 2+ release, resulting in cardiac hypertrophy and HF in murine and canine models. xref , xref Our results suggest that estradiol treatment led to tighter control of cardiac Ca 2+ physiology and improved diastolic relaxation."
30571375
sparser
"Of these, six LR interactions were highlighted by both analyses, including APOE-SORL1 , APOE-LRP1, CALM1-CACNA1C, CALM1-RYR2, CALM3-CACNA1C, CALM3-RYR2 ( xref ). xref illustrates that the LR pair APOE-SORL1 was downregulated in astrocytes-to-neurons and in microglia-to-neurons signaling."
37790454
sparser
"The same group performed functional experiments expressing the mutant protein on a cellular model and found a defective interaction of CALM1 with RYR2 at low calcium concentrations."
27100291
sparser
"The interactions between CALM1 and RYR2 hub genes were revealed using a cutoff of 21% alteration."
32801999
sparser
"Inhibition of [3H]-ryanodine binding by CAM was phosphorylation-independent, had an IC50 of approximately 0.1 microM and was optimal at 10 microM Ca(2+)."
8055547
biogrid
No evidence text available
26164367
reach
"RYR2 is a receptor to CALM1, and the binding of CALM1 to RYR2 has been shown to limit neuronal loss in AD [58]."
38167548
sparser
"Among them, ten LR gene pairs ( CALM1-GRM5, CALM1-GRM7, CALM1-RYR2, CALM-GRM5, and CALM3-GRM7, CALM3-RYR2, CALM1-CACNA1C, CALM3-CACNA1C, CALM3-EGFR, CALM3-INSR ) were prioritized in the pathway analyses."
37790454
sparser
"Moreover, we found that the four distinct niche compositions, apart from ACMs, collectively influenced VCM gene expression through the same sets of L-R pairs ( Vim-Cd44, Calm1-Ryr2, Igf2-Igf2r …), many of which have been implicated in the regulation of CM proliferation, migration, and differentiation xref , xref (Supplementary Figs.  xref , xref )."
40258830
sparser
"Among them, ten LR gene pairs ( CALM1-GRM5, CALM1-GRM7, CALM1-RYR2, CALM3 -GRM3, and CALM5-GRM7, CALM3-RYR2, CALM1-CACNA1C, CALM3-CACNA1C, CALM3-EGFR, CALM3-INSR ) were prioritized in the pathway analyses (Additional file xref : Table S6)."
38167548
reach
"In further support of the aforementioned notion, we previously reported that dantrolene, a specific medicine for malignant hyperthermia, binds to the N-terminal domain of RyR1 [26] and RyR2 [27], and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29427818
reach
"RYR2 is a receptor to CALM1, and the binding of CALM1 to RYR2 has been shown to limit neuronal loss in AD [55]."
37790454
sparser
"RYR2 is a receptor to CALM1, and the binding of CALM1 to RYR2 has been shown to limit neuronal loss in AD [ xref ]."
37790454
sparser
"Our pathway analyses highlighted GO BPs—such as regulation of calcium ion transport, second messenger-mediated signaling, and maintenance of location, which encompass four dysregulated LR pairs, including CALM1-RYR2, CALM3-RYR2, CALM1-CACNA1C, and CALM3-CACNA1C (Fig.  xref , Additional file xref : Table S6)."
38167548
sparser
"RYR2 is a receptor to CALM1, and the binding of CALM1 to RYR2 has been shown to limit neuronal loss in AD [ xref ]."
38167548