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RYR2 binds CALM1. 6 / 6
1 | 1 4
sparser
"CALM1 encodes a regulatory protein of RYR2 and is responsible for inhibiting Ca 2+ release from RYR2 in the sarcoplasmic reticulum to maintain a normal contraction‐relaxation cycle. xref Oxidative stress impairs binding of CALM1 to RYR2 , causing aberrant Ca 2+ release, resulting in cardiac hypertrophy and HF in murine and canine models. xref , xref Our results suggest that estradiol treatment led to tighter control of cardiac Ca 2+ physiology and improved diastolic relaxation."
30571375
sparser
"Inhibition of [3H]-ryanodine binding by CAM was phosphorylation-independent, had an IC50 of approximately 0.1 microM and was optimal at 10 microM Ca(2+)."
8055547
sparser
"The interactions between CALM1 and RYR2 hub genes were revealed using a cutoff of 21% alteration."
32801999
sparser
"The same group performed functional experiments expressing the mutant protein on a cellular model and found a defective interaction of CALM1 with RYR2 at low calcium concentrations."
27100291
reach
"In further support of the aforementioned notion, we previously reported that dantrolene, a specific medicine for malignant hyperthermia, binds to the N-terminal domain of RyR1 [26] and RyR2 [27], and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29427818
biogrid
No evidence text available
23040497