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"Specifically, increased CAM expression by pro-inflammatory stimuli has been observed in a number of cardiovascular pathologies, which include atherosclerosis, hypoxia-induced pulmonary hypertension, and acute lung injury. xref – xref The nuclear factor NF-κB has emerged as a central coordinator key to the transactivation of CAM genes in response to inflammatory cues. xref The co-factors involved in this process that fine-tune NF-κB dependent CAM activation and their pathophysiological relevance in CVD, however, are not well understood."