IndraLab

Statements


CALM1 activates ADCY. 6 / 6
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"The observed constitutive GPCR phosphorylation of a CAM beta 2 receptor causes blunting of the subsequent adenylate cyclase activation, leading to an underestimation of the actual GPCR activity [32]."

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"10 Gnegy, M.E., Murihead, N. and Harrison, J.K., Regulation of cal- modulin- and dopamine stimulated adenylate cyclase activities by light in bovine retina, J. Neurochem., 42 (1984) 1632-1640."

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"Gnegy M. E., Murihead N. and Harrison J. K. (1984) Regulation of calmodulin- and dopamine- stimulated adenylate cyclase activities by light in bovine retina."

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"However, cal- modulin activates adenylate cyclase in only a few tissues (3-6) suggesting a specific site of action associated with some but not all cyclases."

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"These results suggest that the Ca2 +-dependent binding of cal- modulin to specific high affinity sites on brain membranes regulates the activation of adenylate cyclase by cal- modulin."

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"Activation of brain adenylate cyclase by calmo dulin."