IndraLab

Statements

CALM1 binds H1-0. 5 / 5
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"Total protein level of H1.0 was increased to 1.5-fold in the cortex of Cam-tTA:Fl-H1.0 mice ( xref ), while the levels of MeCP2, other H1s, and H3 modifications associated with linker H1 remained unchanged ( xref and xref ) xref ."
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"To further examine the effect of H1.0 overexpression on the genomic distribution of MeCP2, we performed ChIP-Seq using frontal cortex of wild-type and Cam-tTA:Fl-H1.0 mice (3 months old)."
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"To address whether Fl-H1.0 expression affected MeCP2 binding to DNA, we measured MeCP2 enrichment by ChIP-qPCR at sites identified as rich for MeCP2 binding xref , xref , and found no change in Cam-tTA:Fl-H1.0 mice ( xref ) xref , xref ."
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"These results were similarly observed in both wild-type and Cam-tTA:Fl-H1.0 mice ( xref )."
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"Further analysis revealed little change in MeCP2 distribution upon Fl-H1.0 expression: Principal component analysis revealed no clear separation between wild-type and Cam-tTA:Fl-H1.0 mice ( xref ); Spearman correlation coefficients of MeCP2 enrichment between wild-type and Cam-tTA:Fl-H1.0 mice was 0.93 at the binning size of 10 kb ( xref )."
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