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Statements

CALM1 binds CALM2 and CALM3. 4 / 4
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"Mutations in human genes CALM1, CALM2, and CALM3 have been associated with life-threatening heart disorders, such as long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia."
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"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for congenital arrhythmia susceptibility. xref – xref At least 12 mostly de novo mutations have been discovered in CALM1, CALM2, and CALM3 associated with LQTS, CPVT or idiopathic ventricular fibrillation."
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"Collectively, these findings indicate that CaM1, CaM2 and CaM3 interact with the molecular motor MyoH at the conoid, likely regulating its activity in a calcium-dependent manner."
28475612
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"There are three CaM genes producing identical proteins [20] , which are all expressed in cardiac tissue and mutations in CALM1, CALM2 or CALM3 have been associated with potentially life-threatening a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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