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CALM1 binds EP. 58 / 58
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"Moreover, epithelial-mesenchymal transition (EMT) occurs as the epithelial cell markers E-cadherin , EP-CAM , Ocln and Cldn3 decrease and the mesenchymal cell markers N-cadherin , Snail , Slug and Fn increase during long-term culture of ECSC isk (Fig. xref )."
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"TNFR2 ligands were mainly on CD45 − EP-CAM + lung epithelial cells at steady state (Fig.  xref )."
31959883
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"This type of binding is specifically formed between EP-CAM antibodies and MCF-7 cells."
33479404
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"The pro-metastatic effect of G9a observed in lung cancer is attributed to gene silencing of epithelial cell adhesion molecule (ep-CAM ), enhancing invasion [ xref ]."
33803458
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"Finally, levels of epithelial cell adhesion molecule (Ep‐CAM) and E‐selectin (SELE) found exclusively in epithelial and endothelial cells, respectively, were significantly higher in SEVs from patients with severe disease, albeit a less than 1.5‐fold increase compared to the uninfected controls."
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"Ep‐CAM, as a downstream target gene of Wnt/β‐catenin signal, was positively expressed in non‐responders, which means Ep‐CAM could be a biomarker for IFNAR2‐positive patients resistant to IFN/5‐Fu. xref "
33586359
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"Western blotting was used to evaluate the expression of ASPP2, LAMB3, HSPB1, EP-CAM, and Ki67 ( xref )."
36107005
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"Expression of CDCP1 in cell lines is similar to that of the well documented tumour markers CEA and EP-CAM and like these molecules, CDCP1 might prove to be a useful therapeutic target."
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"CD24, CD26, CD44, CD133, CD166, CD34, aldehyde dehydrogenase (ALDH) and Ep‐CAM (also called CD326 or epithelial‐specific antigen/ESA) are some examples of CSC‐specific surface markers."
34687963
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"Using a panel of monoclonal antibodies to keratinocyte differentiation and proliferation markers, we investigated the association of EP-CAM expression with differentiation-related and/or neoplastic changes in cervical epithelium."
8774141
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"Effects of ALT1 and EP-CAM knockdown on MMPs and EMT in HCC."
36107005
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"To further assess CRC organoids, immunohistochemical multiplex fluorescent IHC and immunohistochemical analysis showed that organoids expressed the stemness‐specific surface marker CD44, the epithelial cell adhesion molecule (Ep‐CAM) and the colorectal adenocarcinoma biomarker CEA."
35978266
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"Western blot detection showed that the expression of MMP2 and MMP9 was suppressed when ALT1 and EP-CAM were knocked down ( xref )."
36107005
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"Despite increased expression of the E-cadherin mRNA, the expression of N-cadherin, Snail, and Twist was decreased. ( xref ) These results suggested that after ALT1 interacted with EP-CAM, it participated in the migration and invasion of HepG2 cells by influencing EMT and MMPs."
36107005
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"The nodule was superficially biopsied and epithelial cells stained positive for EP-CAM, variably positive for MCK, CK7, CK20, and CEA, and basal cells stained positive for p63."
39071199
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"Other commonly reported TAAs which are over-expressed in ovarian cancer and can serve as potential biomarkers for immunotherapy include Cancer Antigen 125 (CA125) or Mucin 16 (MUC 16), ( xref ; xref ; xref ; xref ; xref ) Melanoma Antigen Gene - MAGEA1, MAGEA3, MAGEA4, MAGEC1, MAGEA10 protein family, ( xref ; xref ; xref ; xref ; xref ; xref ; xref ) New York Esophageal squamous cell carcinoma-1 (NY-ESO-1), ( xref ; xref ) Cancer Testis antigen-45 (CT45), ( xref ; xref ; xref ; xref ) Folate Receptor alpha (FOLR1), ( xref ; xref ; xref ) Epithelial Cellular Adhesion Molecule (EP-CAM), ( xref ; xref ; xref ) Erythroblastic Oncogene B (ERBB) also frequently called Human Epidermal growth factor Receptor 2 (HER-2/neu), ( xref ; xref ; xref ) Wilm’s Tumour suppressor gene 1 (WT1), ( xref ; xref ; xref ; xref ; xref ) Baculoviral IAP repeat containing protein 5 (BIRC-5), ( xref ; xref ) Preferentially expressed antigen in melanoma (PRAME), ( xref ; xref ; xref ) Trophoblast glycoprotein (TPBG) ( xref ) and Mucin 1 (MUC-1). ( xref ; xref ) The expression of Prostate, Ovary, Testes Expressed ankyrin domain family (POTE gene family) in EOC and HGSC has also been studied."
36420446
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"hAECs were weakly positive for EP-CAM [ xref ], and SSEA3 ( xref )."
32621591
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"It has been confirmed that cancer cells can have certain properties of the source cells.[ xref ]For example, keratin can still be synthesized in epithelial cancers and the HCC cells can express hepatocyte markers in the embryonic stage such as AFP, EP-CAM, and CK8."
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"EP-CAM, KI67, and ASPP2 were captured by co-IP with ALT1 used as a bait protein, indicating a direct interaction between ALT1 and these three DEPs. ( xref ) Knockdown of EP-CAM and KI67 decreased the expression of ALT1, while knockdown of ASPP2 increased ALT1 expression. ( xref )."
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"Immunohistochemical analysis demonstrated positive staining for CK (AE1/AE3), CK8/18, CK19, MOC31 (EP-CAM), and Ber-EP4, while negative staining was observed for CK7, D2-40, WT-1, MC, PAX-8, NKX3.1, PSA, CEA, TTF-1, and NapsinA."
39385147
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"The strong expression of CD44 and EP-CAM highlighted the cells are of epithelial origin."
33066562
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"Due to the high MMP reaction activity of the target CTCs, the detection and counting of CTCs can be realized by the resonance fluorescence transfer phenomenon generated by the enzymatic reaction system. xref labeled the target protein on CTCs with magnetic nanoparticles loaded with antibody and fluorescence coding at the same time, captured CTCs with a chip under an external magnetic field ( xref ), and characterized the contents of epidermal growth factor receptor (EGFR), HER2 and EP-CAM on a single CTC through fluorescence intensity."
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"Homotypic cell–cell interactions are facilitated by several specialized junctional molecules and their associated plaque proteins including tight junctions, adherens junctions, desmosomes, gap junctio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15108808
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"Vicia faba agglutinin, the lectin present in broad beans increases differentiation of a colorectal carcinoma cell line and may act through binding to the cell surface adhesion molecule, ep-CAM [117]."
15992039
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"Cells tested positive for cytokeratin, epithelial cell‐adhesion molecule (Ep‐CAM), E‐cadherin, mucin‐1, and TTF‐1 under conditions of adhesion, suspension, or 3D culture."
39568148
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"Based on the Western blot and RT-qPCR analyses, we concluded that ALT1 influenced EMT and MMPs by interacting with EP-CAM."
36107005
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"Changes in the expression of cell-cell (e.g. EP-CAM, N-CAM and E-, N- and R-cadherins) and cell-extracellular matrix (e.g. integrins) adhesion molecules, as well as extracellular matrix degrading enzy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, the crosslinked positions found within the well‐known integral membrane proteins integrin β1, Ep‐CAM and CD9 were also consistent with the documented membrane topology, where most of the intralinks were found between residues in the extracellular domain (Figure xref )."
35918900
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"EP-CAM is a 35-kDa molecule with the capability of transmembrane glycoprotein cell adhesion, which is associated with the adhesion of Ca 2+ -independent adhesion between cells [ xref , xref ]."
36107005
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"Additionally, EP-CAM has been applied in the detection of circulating tumor cells [ xref , xref ]."
36107005
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"Previous studies have suggested that EP-CAM is associated with cell migration, invasion, signal transduction, and differentiation [ xref , xref ]."
36107005
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"To further investigate the effect of arctigenin on mucosal healing, we labeled the mouse colonic epithelial cells using EP-CAM and observed that arctigenin promoted the repair of the epithelial layer [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38280335
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"In addition, specific homologous binding adhesion proteins (EP-CAM and N-cadherin) for nanomedicine were analyzed using western blotting."
36201946
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"Furthermore, EP-CAM can regulate MMP2 and MMP9 in gastric cancer by activating the NFκB signaling pathway [ xref ]."
36107005
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"In addition, USC express the renal cortex markers sine oculis homeobox homologue 2 (SIX2), neural cell adhesion molecule (NCAM), epithelial cell adhesion molecule (ep-CAM), and frizzled class receptor (FZD), suggesting their origin from the kidney [ xref – xref ]."
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"The overexpression of EP-CAM in breast cancer, ovarian cancer, and head and neck squamous cell cancer has shown a negative impact on cancer prognosis [ xref – xref ]."
36107005
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"Even though most cases of EH and EC are isolated, some genetic diseases significantly increase the risk, such as Lynch Syndrome, also known as hereditary non-polyposis colonic cancer (HNPCC), caused by a mutation in one of the genes involved in the DNA repair system (MLH1, MSH2, MSH6, PMS2, and EP-CAM) [ xref ]."
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"EP-CAM can strengthen the tumor-initiating ability by influencing EMT, which is induced through N-glycosylation of EpCAM in breast cancer [ xref – xref ]."
36107005
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"Considering the kidney origin, USC is also positive for renal cell markers such as sine oculis homeobox homolog 2 (SIX2), neural cell adhesion molecule (NCAM), and epithelial cell adhesion molecule (ep-CAM), and frizzled class receptor (FZD) [ xref , xref , xref ]."
36015295
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"By adding some interfering substances, magnetite nanoparticles can be bound to the EP-CAM antibodies, which in turn, specifically bind to the antigens on MCF-7 cells."
33479404
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"Based on the above studies, we selected EP-CAM as the key DEP to determine whether ALT1 was involved in migration and invasion."
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"This pellet was washed with RBC lysis buffer (Beyotime, Cat# C3702) for 3 min, and the cells were spun for 5 min at 2000 rpm at 4 °C. Then, the cells were stained with the fixable viability dye ZomBie NIR and anti‐mouse CD45‐PE antibody as well as anti‐mouse CD326 (Ep‐CAM)‐FITC, and sorted by BECKMAN COULTER MoFlo XDP."
39225354
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"In this study, silencing ALT1 and EP-CAM expression in HepG2 cells contributed to alterations in the mRNA expression of EMT-related biomarkers, including E-cadherin, N-cadherin, Snail, and Twist, and changes in MMP2 and MMP9."
36107005
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"CD9, CD63, Alix, and EP-CAM can be enriched by antibody-coated magnetic beads."
34335792
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"The pro-metastatic effect of G9a is contributed by gene silencing of epithelial cell adhesion molecules (ep-CAM), increasing the invasive capacity of lung tumor cells ( xref )."
34901003
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"STAIB L, BIREBENT B, SOMASUNDARAM R et al.: Immunogenicity of recombinant GA7332E antigen (CO17-1a, Egp, KS1-4, KSA, EP-CAM) in gastrointestinal carcinoma patients."
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"To further investigate the effect of DPN and LIQ on mucosal healing, we labeled the epithelial cells in colon sections using EP-CAM."
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"For example, the protein methyltransferase G9a promotes cell invasion and metastasis through the cell adhesion molecule epithelial cell adhesion molecule (Ep‐CAM) in lung cancer. xref Besides, Slimane et al. found that SETDB1 is overexpressed in NSCLC and related to cell proliferation and invasion, which is a promising tool for predicting tumor recurrence in early NSCLC patients. xref , xref , xref , xref Similarly, many studies have reported the carcinogenic effect of KDM5B. Compared with normal tissues, KDM5B has higher expression in tumor tissues. xref KDM5B is associated with malignant proliferation and metastasis of cancer cells, and it has the potential to be a prognostic factor for lung cancer. xref , xref , xref At the epigenetic level, abnormal changes in PTMs directly affect programmed cell death 1 ligand 1(PD‐L1)‐mediated immune resistance, xref , xref and acetylation of H3K14 and HBO1 participate in the transcription of PD‐L1."
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"The first bi-specific antibody to gain regulatory approval was Catumaxomab, which targeted CD3 on T cells and EP-CAM on tumor cells and was approved in 2009 by the European Union for the treatment of malignant ascites in patients with EpCAM-positive disease [115]."
34638271
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"To employ the hybrid plan, magnetite nanoparticles were bound to MCF-7 cells through the specific EP-CAM antibodies."
33479404
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"Knockdown of ALT1 in HepG2 cells reduced the expression of Ki67 and epithelial cell adhesion molecule (EP-CAM), while the expression of apoptosis-stimulating protein 2 of p53 (ASPP2) was increased significantly."
36107005
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"At present, 9769 proteins have been identified in exosomes from different sources, such as CD9, CD63, CD81, Alix, EP-CAM, Hsp70, Tsg101, CD55, and CD59 [ xref ]."
34335792
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"In addition, CD9, CD63, Alix, and EP-CAM can be used for the isolation of exosomes."
34335792
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"Suppression of the ALT1 and EP-CAM expression contributed to alterations in epithelial–mesenchymal transition (EMT) -associated markers and matrix metalloproteinases (MMPs)."
36107005
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"The exosomes derived from mesenchymal stem cells (MSCs-EXs) express various markers such as CD9, CD63, CD55, CD59, CD81, Alix, and EP-CAM on their surface."
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"AFP is indicative of a biologically distinct subtype of HCC, often associated with poor prognosis and more stem‐cell‐like features (such as Epithelial Cell Adhesion Molecule [Ep‐CAM] expression), increased vascular endothelial growth factor (VEGF) pathway activity, and increased activity of VEGFR2‐targeted antibodies in preclinical models [ xref , xref ]."
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"CD9, CD63, Alix, and EP-CAM are the markers used for the isolation of exosomes."
37376125
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"The mRNA expression levels of ASPP2, LAMB3 (laminin subunit beta-3), HSPB1 (heat shock protein beta-1), KDM6A (lysine-specific demethylase 6A), annexin A2, PDIA6 (protein disulfide-isomerase A6), EP-CAM, and Ki67 were detected by RT-qPCR ( xref )."
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