IndraLab

Statements

CALM1 binds EP. 39 / 39
| 39
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"EP-CAM, KI67, and ASPP2 were captured by co-IP with ALT1 used as a bait protein, indicating a direct interaction between ALT1 and these three DEPs. ( xref ) Knockdown of EP-CAM and KI67 decreased the expression of ALT1, while knockdown of ASPP2 increased ALT1 expression. ( xref )."
36107005
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"Using a panel of monoclonal antibodies to keratinocyte differentiation and proliferation markers, we investigated the association of EP-CAM expression with differentiation-related and/or neoplastic changes in cervical epithelium."
8774141
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"Knockdown of ALT1 in HepG2 cells reduced the expression of Ki67 and epithelial cell adhesion molecule (EP-CAM), while the expression of apoptosis-stimulating protein 2 of p53 (ASPP2) was increased significantly."
36107005
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"CD9, CD63, Alix, and EP-CAM can be enriched by antibody-coated magnetic beads."
34335792
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"To employ the hybrid plan, magnetite nanoparticles were bound to MCF-7 cells through the specific EP-CAM antibodies."
33479404
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"TNFR2 ligands were mainly on CD45 − EP-CAM + lung epithelial cells at steady-state ( xref )."
31959883
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"The first bi-specific antibody to gain regulatory approval was Catumaxomab, which targeted CD3 on T cells and EP-CAM on tumor cells and was approved in 2009 by the European Union for the treatment of malignant ascites in patients with EpCAM-positive disease [115]."
34638271
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"Effects of ALT1 and EP-CAM knockdown on MMPs and EMT in HCC."
36107005
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"EP-CAM can strengthen the tumor-initiating ability by influencing EMT, which is induced through N-glycosylation of EpCAM in breast cancer [ xref – xref ]."
36107005
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"Based on the above studies, we selected EP-CAM as the key DEP to determine whether ALT1 was involved in migration and invasion."
36107005
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"Previous studies have suggested that EP-CAM is associated with cell migration, invasion, signal transduction, and differentiation [ xref , xref ]."
36107005
sparser
"Based on the Western blot and RT-qPCR analyses, we concluded that ALT1 influenced EMT and MMPs by interacting with EP-CAM."
36107005
sparser
"This type of binding is specifically formed between EP-CAM antibodies and MCF-7 cells."
33479404
sparser
"The pro-metastatic effect of G9a is contributed by gene silencing of epithelial cell adhesion molecules (ep-CAM), increasing the invasive capacity of lung tumor cells ( xref )."
34901003
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"Western blot detection showed that the expression of MMP2 and MMP9 was suppressed when ALT1 and EP-CAM were knocked down ( xref )."
36107005
sparser
"By adding some interfering substances, magnetite nanoparticles can be bound to the EP-CAM antibodies, which in turn, specifically bind to the antigens on MCF-7 cells."
33479404
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"The overexpression of EP-CAM in breast cancer, ovarian cancer, and head and neck squamous cell cancer has shown a negative impact on cancer prognosis [ xref – xref ]."
36107005
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"Moreover, epithelial-mesenchymal transition (EMT) occurs as the epithelial cell markers E-cadherin , EP-CAM , Ocln and Cldn3 decrease and the mesenchymal cell markers N-cadherin , Snail , Slug and Fn increase during long-term culture of ECSC isk (Fig. xref )."
| PMC
sparser
"4P–R) and collagen III positive and were SP-A, cytokeratin, EP-CAM, CD-45, CD-68 and CD-31 negative (data not shown), indicating that these infected cells are fibroblasts."
18022664
sparser
"To further assess CRC organoids, immunohistochemical multiplex fluorescent IHC and immunohistochemical analysis showed that organoids expressed the stemness‐specific surface marker CD44, the epithelial cell adhesion molecule (Ep‐CAM) and the colorectal adenocarcinoma biomarker CEA."
35978266
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"Furthermore, EP-CAM can regulate MMP2 and MMP9 in gastric cancer by activating the NFκB signaling pathway [ xref ]."
36107005
sparser
"In this study, silencing ALT1 and EP-CAM expression in HepG2 cells contributed to alterations in the mRNA expression of EMT-related biomarkers, including E-cadherin, N-cadherin, Snail, and Twist, and changes in MMP2 and MMP9."
36107005
sparser
"The small, cuboidal cells stained positive for SP-A, cytokeratin, EP-CAM, and a type II cell-specific antibody obtained from Dr."
18022664
sparser
"The mRNA expression levels of ASPP2, LAMB3 (laminin subunit beta-3), HSPB1 (heat shock protein beta-1), KDM6A (lysine-specific demethylase 6A), annexin A2, PDIA6 (protein disulfide-isomerase A6), EP-CAM, and Ki67 were detected by RT-qPCR ( xref )."
36107005
sparser
"In addition, CD9, CD63, Alix, and EP-CAM can be used for the isolation of exosomes."
34335792
sparser
"Despite increased expression of the E-cadherin mRNA, the expression of N-cadherin, Snail, and Twist was decreased. ( xref ) These results suggested that after ALT1 interacted with EP-CAM, it participated in the migration and invasion of HepG2 cells by influencing EMT and MMPs."
36107005
sparser
"Western blotting was used to evaluate the expression of ASPP2, LAMB3, HSPB1, EP-CAM, and Ki67 ( xref )."
36107005
sparser
"Suppression of the ALT1 and EP-CAM expression contributed to alterations in epithelial–mesenchymal transition (EMT) -associated markers and matrix metalloproteinases (MMPs)."
36107005
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"Ep‐CAM, as a downstream target gene of Wnt/β‐catenin signal, was positively expressed in non‐responders, which means Ep‐CAM could be a biomarker for IFNAR2‐positive patients resistant to IFN/5‐Fu. xref "
33586359
sparser
"Finally, levels of epithelial cell adhesion molecule (Ep‐CAM) and E‐selectin (SELE) found exclusively in epithelial and endothelial cells, respectively, were significantly higher in SEVs from patients with severe disease, albeit a less than 1.5‐fold increase compared to the uninfected controls."
34262673
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"TNFR2 ligands were mainly on CD45 − EP-CAM + lung epithelial cells at steady state (Fig.  xref )."
31959883
sparser
"hAECs were weakly positive for EP-CAM [ xref ], and SSEA3 ( xref )."
32621591
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"EP-CAM is a 35-kDa molecule with the capability of transmembrane glycoprotein cell adhesion, which is associated with the adhesion of Ca 2+ -independent adhesion between cells [ xref , xref ]."
36107005
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"The small cuboidal cells were positive for SP-A (A–C), cytokeratin (D–F), EP-CAM (G–I), and a type II cell monoclonal antibody (J–L)."
18022664
sparser
"At present, 9769 proteins have been identified in exosomes from different sources, such as CD9, CD63, CD81, Alix, EP-CAM, Hsp70, Tsg101, CD55, and CD59 [ xref ]."
34335792
sparser
"Additionally, EP-CAM has been applied in the detection of circulating tumor cells [ xref , xref ]."
36107005
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"The strong expression of CD44 and EP-CAM highlighted the cells are of epithelial origin."
33066562
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"In addition, USC express the renal cortex markers sine oculis homeobox homologue 2 (SIX2), neural cell adhesion molecule (NCAM), epithelial cell adhesion molecule (ep-CAM), and frizzled class receptor (FZD), suggesting their origin from the kidney [ xref – xref ]."
29996911
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"The pro-metastatic effect of G9a observed in lung cancer is attributed to gene silencing of epithelial cell adhesion molecule (ep-CAM ), enhancing invasion [ xref ]."
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