IndraLab

Statements

USP7 affects TP53
2 1 1 | 86
USP7 deubiquitinates TP53. 10 / 83
1 1 | 81
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"This result indicates that ABRO1 specifically facilitates USP7 mediated deubiquitination of p53."
25283148
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"USP7 deubiquitinates several tumour suppressors (p53, PTEN, FOXO and claspin) and E3 ligases (MDM2, Mule and viral proteins ICP0) and therefore regulates important signalling pathways that are involved in tumorigenesis XREF_BIBR XREF_BIBR."
25960197
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"The observation that HAUSP can directly interact with and deubiquitylate both p53 and MDM2 creates a conundrum : how can HAUSP stabilize p53 while at the same time being able to stabilize MDM2, which is primarily responsible for the destruction of p53?"
16402859
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"XREF_BIBR - XREF_BIBR USP7 deubiquitinates and stabilizes not only p53, but also Mdm2, the primary E3 ubiquitin ligase of p53 XREF_BIBR, XREF_BIBR Given that both p53 and Mdm2 are known regulators of the steady-level of Poleta, we speculated that changes in cellular USP7 levels may also modulate Poleta level."
25435364
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"Ubiquitin specific protease 7 (USP7) deubiquitinates p53 and Hdm2 and regulates their stability."
26786098
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"Via these interactions, MLF2 inhibits the binding of USP7 to p53 and antagonizes USP7-mediated deubiquitination of p53, thereby leading to p53 destabilization."
37438558
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"In particular, USP7 deubiquitinates p53 and WASH (part of the Wiskott–Aldrich Syndrome protein family), suggesting its role in disrupting tumor suppression pathways [23]."
32101552
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"USP7, also known as the hepes simplex virus associated ubiquitin specific protease (HAUSP), deubiquitinates both mdm2 and p53, and plays an important role in regulating the level and activity of p53."
20816748
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"In addition, USP7 may deubiquitinate p53 via Mdm2."
28406480
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"The first structure corresponds to USP7 (also known as HAUSP, Herpes associated USP), a DUB that preferentially deubiquitinates MDM2 (Murine Double Minute 2), the ubiquitin ligase for the tumor suppressor p53, as well as p53 itself XREF_BIBR."
19243136
Modified USP7 leads to the deubiquitination of TP53. 3 / 3
| 3
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"There also seems to be a delicate balance between these proteins, as a modest reduction of HAUSP levels prevents p53 deubiquitination but complete ablation of HAUSP causes robust p53 stabilization."
20404858
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"As shown in XREF_FIG, Mdm2 induced the ubiquitination of p53; however, p53 ubiquitination was significantly diminished by coexpression of USP10 or HAUSP."
20096447
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"The expression of USP7/HAUSP prevents p53 ubiquitination from Mdm2 as a p53-specific E3 ligase and increases the p53 protein stability [25]."
| PMC
USP7 deubiquitinates TP53 on lysine. 2 / 2
2 |
biopax:reactome
No evidence text available
biopax:pid
No evidence text available
17268548
USP7 deubiquitinates ubiquitinated TP53. 2 / 2
| 2
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"HAUSP specifically deubiquitinates the ubiquitinated p53 protein both in vitro and in vivo, and the expression of HAUSP was found to stabilize p53 in vivo and to promote p53 dependent cell growth arre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12507430
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"Single- or double ubiquitinated p53 are deubiquitinated by a protein called HAUSP XREF_BIBR."
25504419
USP7 affects MDM2
1 1 | 1 58
USP7 deubiquitinates MDM2. 10 / 61
1 1 | 1 58
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"Thus USP7 would be posited to have opposing effects depending on whether it predominantly deubiquitinates and rescues p53 or MDM2."
20073038
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"USP7 deubiquitinates both p53 and MDM2, one of the ubiquitin ligases that ubiquitylates p53, thereby stabilizing both proteins [XREF_BIBR, XREF_BIBR]."
29142505
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"USP7 preferentially deubiquitylates the E3 ligase HDM2 and its binding partner HDMX as well as their substrate p53 (Brooks et al., 2007; Cummins and Vogelstein, 2004; Li et al., 2002, 2004; Meulmeeste[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22118674
ubibrowser
"Review"
28801249
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"USP7 deubiquitinates Mdm2 and p53, and its overexpression causes Mdm2 and p53 stabilization."
26460617
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"In the normal state, HAUSP specifically binds to and deubiquitinates Mdm2, thereby stabilizing Mdm2 and subsequently inducing the proteasomal degradation of p53 through Mdm2 activity."
25695607
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"XREF_BIBR - XREF_BIBR USP7 deubiquitinates and stabilizes not only p53, but also Mdm2, the primary E3 ubiquitin ligase of p53 XREF_BIBR, XREF_BIBR Given that both p53 and Mdm2 are known regulators of the steady-level of Poleta, we speculated that changes in cellular USP7 levels may also modulate Poleta level."
25435364
reach
"HAUSP not only deubiquitinates p53, but also Mdm2."
19450511
reach
"USP7, also known as the hepes simplex virus associated ubiquitin specific protease (HAUSP), deubiquitinates both mdm2 and p53, and plays an important role in regulating the level and activity of p53."
20816748
reach
"USP7 preferentially deubiquitylates the E3 ligase HDM2 and its binding partner HDMX, resulting in the destabilisation of p53 and the repression of p53 transactivation activity."
22088887
USP7 affects PTEN
2 1 | 1 18
USP7 deubiquitinates PTEN. 10 / 20
1 | 1 18
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"However, PTEN is deubiquitinated by USP7/HAUSP and released to the cytoplasm on the PML-RARα signaling network [24]."
| PMC
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"XREF_BIBR, XREF_BIBR, XREF_BIBR The DUB USP7 can reverse PTEN monoubiquitylation, affecting its cellular localization; 28 however, to date no DUBs have been described that reverse PTEN polyubiquitylation or otherwise influence PTEN expression levels."
24292675
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"More recently, the ability of USP7 to deubiquitinate PTEN was found to be under the control of BCR-ABL."
25605410
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"HAUSP deubiquitinates PTEN to cause its nuclear exclusion, leading to tumour aggressiveness XREF_BIBR."
27934968
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"Furthermore, USP7 overexpression reduces phosphatase and tensin homolog (PTEN) monoubiquitination and leads to PTEN nuclear exclusion, which is associated with a more aggressive phenotype (Song et al., 2008)."
36186590
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"245 HAUSP (herpesvirus associated ubiquitin specific protease) deubiquitinates PTEN in the nucleus."
24830552
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"On the other hand, reversal of PTEN monoubiquitination by USP7 (also known as HAUSP) alters PTEN subcellular localization without affecting its protein level [XREF_BIBR]."
27844253
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"We have demonstrated that PTEN monoubiquitination at lysines 13 and 289 is essential for its nuclear localization and tumor suppressive function and, conversely, deubiquitination of PTEN by HAUSP renders PTEN predominantly cytoplasmic."
21241890
trips
"In this study, we show that BCR-ABL enhances HAUSP-induced de-ubiquitination of PTEN in turn favoring its nuclear exclusion."
24317448
reach
"USP7 in turn deubiquitinates PTEN and promotes its exclusion from the nucleus (24)."
20073038
USP7 deubiquitinates PTEN ubiquitinated on K13 on K289. 1 / 1
1 |
biopax:reactome
No evidence text available
USP7 deubiquitinates PTEN ubiquitinated on K289 on K13. 1 / 1
1 |
biopax:reactome
No evidence text available
USP7 affects Histone_H2B
| 22
USP7 deubiquitinates Histone_H2B. 10 / 22
| 22
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"We have observed that USP7 silencing increases H2B ubiquitylation at the FR as well as at LMP1 and Cp promoters and decreases transcriptional activation from the FR element, suggesting that H2B ubiquitylation is inhibitory to transcription controlled by the FR."
19834552
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"This prompted us to investigate whether the human USP7 and GMPS complex also functioned to deubiquitylate histone H2B."
19834552
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"EBNA1 can also recruit USP7 to EBV sequences that regulate viral gene expression and genome persistence where, in complex with GMP synthetase, USP7 can deubiquitylate histone H2B and affect EBNA1 mediated transcriptional activation XREF_BIBR."
21305000
reach
"GMPS enables USP7 dependent deubiquitination of histone H2B resulting in epigenetic silencing [XREF_BIBR - XREF_BIBR]."
26046769
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"In addition to USP22 and its yeast homolog, H2B can be deubiquitylated by USP3 and USP7 in humans."
21513801
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"GMPS is not only involved in nucleotide biosynthesis but also modulates the function of USP7 deubiquitination of both H2B and p53, resulting in epigenetic silencing and DNA repair respectively."
25605410
reach
"While it is possible that this is because USP7 can deubiquitylate H2A, in addition to H2B, it also remains possible that the USP7 mediated deubiquitylation of H2B has some regulatory interaction with Polycomb function."
21513801
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"GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7."
15749019
reach
"Although it has been previously demonstrated that USP7 can deubiquitylate histone H2B in vitro, there is no evidence that this occurs in living cells."
21138959
reach
"Hausp has also been shown to interact with Guanosine 5 '-monophosphate synthetase in Drosophila, and together mediate the deubiquitination of histone H2B, which is important for the epigenetic silencing of homeotic genes mediated by the Polycomb protein."
19946331
USP7 affects FOXP3
1 | 16
USP7 deubiquitinates FOXP3. 10 / 10
1 | 9
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"On the other hand, the deubiquitinase USP7 is able to deubiquitinate FOXP3 in an HSP90 dependent manner and stabilizes FOXP3 to increase Treg number to enhance Treg suppressive activity."
26441996
ubibrowser
"Furthermore, cambogin (10 μM) prevented Foxp3 loss in human primary Treg cells in vitro, and promoted USP7-mediated Foxp3 deubiquitination and increased Foxp3 protein expression in LPS-treated cells."
29352742
reach
"E3 ubiquitin ligase Stub1 induces the K48 polyubiquitination and degradation of Foxp3, whereas deubiquitinase USP7 decreases Foxp3 polyubiquitination and increases Foxp3 expression XREF_BIBR."
25695215
reach
"USP7 mRNA expression was significantly upregulated in iTreg cells but not in other Th subsets, further supporting a role for the USP7 deubiquitination of Foxp3 in Treg cell differentiation (XREF_FIG)."
23973222
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"USP7 Associates with and Deubiquitinates Foxp3."
23973222
reach
"To determine whether USP7 could also deubiquitinate Foxp3, we analyzed Foxp3 polyubiquitination in transfected HEK 293T cells."
23973222
reach
"In a previous study, van Loosdregt et al. (2013) showed that USP7 interacted with and deubiquitinated Foxp3, thereby increasing Foxp3 protein levels."
29352742
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"Conversely, the DUB Usp7 deubiquitinates and stabilizes Foxp3 to promote Treg functions."
27012466
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"In addition, utilizing the UbiTest analysis we demonstrate that inhibition of USP7 increases polyubiquitination of Foxp3, Tip60 and USP7."
29236775
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"Foxp3 polyubiquitination was reduced with ectopic expression of USP7, indicating that USP7 can directly deubiquitinate Foxp3 (XREF_FIG)."
23973222
USP7 deubiquitinates FOXP3. 3 / 3
| 3
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"Treatment of cells with USP7 inhibitor results in reduced Foxp3 levels while ectopic expression of USP7 decreases Foxp3 ubiquitination and correlates with an increase of Foxp3 expression (114, 115)."
32117202
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"56 In other words, USP7 deubiquitinates Foxp3, increasing Foxp3 protein levels and subsequently up-regulating Treg cells.A knockdown of USP7 expression in the Treg cells leads to a decrease in the Foxp3 protein levels reducing the suppression of the Treg-cell in vitro and vivo.45 USP7 inhibitors can affect the tumour growth limitation in immunocompetent mice and may have a key role in future cancer immunotherapies.56USP7 has also been implicated in regulation of the inflammasome."
35005106
reach
"USP7 is upregulated in Treg cells, and the ectopic expression of USP7 decreases Foxp3 polyubiquitylation and increases Foxp3 expression."
31681337
Modified USP7 leads to the deubiquitination of FOXP3. 3 / 3
| 3
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"Ectopic expression of USP7 specifically decreased Foxp3 polyubiquitination, resulting in increased Foxp3 expression."
25152867
reach
"Ectopic expression of USP7 specifically decreased Foxp3 polyubiquitination, resulting in increased Foxp3 protein expression."
23973222
reach
"Ectopic expression of USP7 decreased Foxp3 polyubiquitination and increased Foxp3 expression."
23973222
Modified USP7 leads to the deubiquitination of FOXP3. 1 / 1
| 1
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"As expected, USP44 or USP7 expression alone reduced ubiquitination of FOXP3, while co-over-expression of both USP44 and USP7 almost completely eliminated FOXP3 polyubiquitination, suggesting a synergistic role of these two DUBs (Fig XREF_FIG C)."
32644293
USP7 affects REST
1 | 14
USP7 deubiquitinates REST. 10 / 11
1 | 10
reach
"These data further support that REST deubiquitination is specifically mediated by HAUSP."
21258371
ubibrowser
"Collectively, our data demonstrate that the hTPH2 NRSE-mediated promoter repression via NRSF involves class I HDACs and is modulated by the ubiquitin-specific protease 7-mediated deubiquitination and stabilization of NRSF."
28464229
reach
"Wt-HAUSP specifically counteracted beta-TrCP-mediated REST ubiquitination, while the Mt-HAUSP or the control deubiquitinase USP1 did not alter the REST ubiquitination (XREF_FIG), suggesting that HAUSP directly and specifically deubiquitinated REST and suppressed REST ubiquitination."
21258371
reach
"We determined that HAUSP physically interacts with REST as demonstrated in co-immunoprecipitation assays (XREF_FIG; XREF_SUPPLEMENTARY), suggesting that HAUSP may mediate REST deubiquitination to prevent REST proteosomal degradation."
21258371
reach
"HAUSP knockdown increased REST poly-ubiquitination as demonstrated by both anti-REST immunoprecipitation (IP) and anti-Ubiquitin reciprocal IP (XREF_FIG; XREF_SUPPLEMENTARY)."
21258371
reach
"HAUSP deubiquitinates REST to promote neural progenitor cell maintenance as discussed earlier."
29967688
reach
"To further address whether REST deubiquitination is directly and specifically mediated by HAUSP, we performed an in vitro deubiquitination assay XREF_BIBR with purified wild-type HAUSP (Flag-Wt-HAUSP), catalytic dead mutant HAUSP (Flag-Mt-HAUSP), or a control deubiquitinase USP1 (Flag-USP1)."
21258371
reach
"We hypothesized that HAUSP functions as a critical counterbalance to beta-TrCP to inhibit REST ubiquitination and maintain NPCs."
21258371
reach
"Collectively, these data demonstrate that HAUSP negatively regulates REST ubiquitination and promotes REST stabilization."
21258371
reach
"Our data demonstrate that HAUSP directly deubiquitinates REST."
21258371
Modified USP7 leads to the deubiquitination of REST. 4 / 4
| 4
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"Moreover, deubiquitination assay demonstrated that expression of Wt-HAUSP but not the Mt-HAUSP attenuated the REST ubiquitination induced by B5 shHAUSP (XREF_FIG), showing that Wt-HAUSP functioned through deubiquitination to stabilize REST and rescued the differentiation phenotype induced by knockdown of endogenous HAUSP."
21258371
reach
"Importantly, overexpression of HAUSP with beta-TrCP together abolished the increased REST ubiquitination induced by beta-TrCP overexpression (XREF_SUPPLEMENTARY, lanes 4, 3)."
21258371
reach
"Consistently, expression of HAUSP reduced REST poly-ubiquitination (XREF_SUPPLEMENTARY, lanes 2, 1), and overexpression of beta-TrCP increased REST ubiquitination (XREF_SUPPLEMENTARY, lanes 3, 2)."
21258371
reach
"Ectopic expression of Wt-HAUSP but not the Mt-HAUSP decreased REST ubiquitination and increased REST protein levels (XREF_FIG; XREF_SUPPLEMENTARY)."
21258371
USP7 affects DNMT1
1 | 13
USP7 deubiquitinates DNMT1. 10 / 12
1 | 11
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"The UHRF1 and DNMT1 complex has been reported to contain USP7 that deubiquitinates and stabilizes DNMT1 XREF_BIBR, XREF_BIBR."
26065575
reach
"Recent evidence has indicated that USP7 also deubiquitinates DNMT1 during S-phase; in late S-phase, acetylation of DNMT1 by Tip60 leads to disruption of the DNMT1 and USP7 complex."
26299963
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"Importantly, both HDAC3 and USP7 decreased DNMT1 ubiquitination (XREF_FIG, DNMT1 IP)."
28490812
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"Consistent with previous studies that USP7 deubiquitinates and stabilizes DNMT1, knockdown of USP7 in several cell lines (HEK293T, HeLa, HCT116 p53-/- and p53 +/+ cells) resulted in a significant decrease in the DNMT1 protein level, but not in the DNMT1 messenger RNA level (XREF_FIG and XREF_SUPPLEMENTARY)."
25960197
reach
"Conversely, HDAC1 (histone deacetylase 1) induced DNMT1 deacetylation and HAUSP (herpes virus associated ubiquitin specific protease) modulated DNMT1 deubiquitination to stabilize DNMT1 44."
29367628
reach
"We recently showed that USP7 deubiquitinates DNMT1 and functions in concert with several other proteins to regulate DNMT1 stability."
23106643
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"Together, these observations suggest that multistep posttranslational modification events may be required to dissociate the UHRF1 and USP7 complex during M phase.Recent evidence has indicated that USP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299963
reach
"FA decreased the ubiquitination of DNMT1 (p = 0.0753), DNMT3A (p = 0.0008) and DNMT3B (p < 0.0001) by decreasing UHRF1 (p < 0.0001) and USP7 (p < 0.0001)."
31060424
reach
"HAUSP deubiquitinates DNMT1 and protects it from proteasomal degradation."
21045206
ubibrowser
"Review"
27775833
Modified USP7 leads to the deubiquitination of DNMT1. 1 / 1
| 1
reach
"Second, DNMT1 ubiquitination was increased in the HAUSP knockout cells (XREF_FIG), whereas overexpression of HAUSP led to deubiquitination of DNMT1 (XREF_FIG)."
21045206
USP7 leads to the deubiquitination of mutated DNMT1. 1 / 1
| 1
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"Experimental controls further showed that (i) a HAUSP C223S (active site) mutant could not remove ubiquitin moieties from DNMT1 (XREF_FIG), and (ii) overexpressed HAUSP failed to deubiquitinate a DNMT1 mutant lacking the HAUSP interaction domain (DNMT1Delta) (XREF_SUPPLEMENTARY)."
21045206
USP7 affects CTNNB1
1 | 12
USP7 deubiquitinates CTNNB1. 10 / 12
1 | 11
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"Conversely, USP7 promotes deubiquitination of beta-catenin with RNF220, which is a RING domain E3 ligase, and upregulates the Wnt signaling pathway [XREF_BIBR]."
32486158
ubibrowser
"USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination"
29045831
reach
"Ubiquitin specific peptidase 7 (USP7) mediates deubiquitination of beta-catenin and enhances canonical Wnt signaling [XREF_BIBR]."
28430641
reach
"Together, our data imply that USP7 interacts with the N terminus of beta-catenin directly to mediate beta-catenin deubiquitination when APC is mutated."
29045831
reach
"USP7 Interacts with the N Terminus of beta-Catenin Directly to Mediate beta-Catenin Deubiquitination."
29045831
reach
"It was reported that USP7 could activate Wnt signaling pathway and promote tumorigenesis by mediating β-catenin deubiquitination in adenomatous polyposis coli (APC) mutations from colon tumors [38]."
34740372
reach
"Indeed, CRISPR targeting of USP7 in the CID deleted APC4 cells readily restored beta-catenin ubiquitination in the destruction complex (XREF_FIG D and XREF_SUPPLEMENTARY I)."
29045831
reach
"Moreover, ZMIZ2 recruits the enzyme USP7, which deubiquitylates and stabilizes beta-catenin, thereby facilitating colorectal tumorigenesis."
31527801
reach
"Specifically, USP7 binds the N-terminus of β-catenin when the APC losses CID confirming the essential role of USP7 in the activation of Wnt signalling and cell survival in colorectal cancers.13 Ma et al showed that the USP7/RNF220 complex activates the Wnt pathway while knockdown of USP7 using a small interfering RNA (siRNA) strategy, reduces the expression of Wnt.18 Conversely, a recent study proposed that USP7 deubiquitinates β-catenin and RNF220 independently and works as a tumour-specific condition when APC is mutated."
35005106
reach
"USP7 Depletion in APC Truncated CRC Cells Suppresses Aberrant Wnt Activation by Restoring beta-Catenin Ubiquitination."
29045831
Modified USP7 leads to the deubiquitination of CTNNB1. 1 / 1
| 1
reach
"Expression of WT USP7 robustly suppressed beta-catenin ubiquitination, as demonstrated by mobility shift, while the C223A mutant expression failed to execute its function (XREF_FIG H and XREF_SUPPLEMENTARY G)."
29045831
USP7 affects KAT5
1 | 1 9
USP7 deubiquitinates KAT5. 10 / 11
1 | 1 9
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"Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway."
29056421
ubibrowser
"USP7 deubiquitinates and stabilizes the acetyltransferase Tip60 to induce p53-dependent apoptotic pathways"
25121098
reach
"Rather, we found that ATF3 promoted USP7 mediated deubiquitination of Tip60 thereby diminishing Tip60 ubiquitination required for proteosomal degradation."
25865756
reach
"As ATF3 appears to bind to MDM2 as well as p53 XREF_BIBR, XREF_BIBR, the observation that ATF3 promoted USP7 mediated deubiquitination of Tip60 suggests a possibility that ATF3 might also regulate the MDM2 or p53 stability through regulating USP7 in the DNA damage response."
25865756
reach
"ATF3 promotes USP7 mediated deubiquitination of Tip60."
25865756
reach
"As ATF3 alone did not appear to decrease the Tip60 ubiquitination level (XREF_FIG, lane 3), these results argue for the notion that ATF3 promoted USP7 mediated deubiquitination of Tip60 thereby stabilizing the latter protein."
25865756
trips
"Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway."
23775119
reach
"In addition, utilizing the UbiTest analysis we demonstrate that inhibition of USP7 increases polyubiquitination of Foxp3, Tip60 and USP7."
29236775
reach
"Here we show that USP7 interacts with and deubiquitinates Tip60 both in vitro and in vivo."
23775119
reach
"USP7, a dominant deubiquitinating enzyme in 3T3-L1 adipocytes and mouse adipose tissue, deubiquitinates Tip60 both in intact cells and in vitro and increases Tip60 protein levels."
24141283
USP7 affects MDM4
1 1 | 1 7
USP7 deubiquitinates MDM4. 10 / 10
1 1 | 1 7
ubibrowser
"Review"
27775833
reach
"USP7 preferentially deubiquitylates the E3 ligase HDM2 and its binding partner HDMX, resulting in the destabilisation of p53 and the repression of p53 transactivation activity (Refs 43, 44, 45)."
22088887
reach
"More recent data suggest that Hausp also deubiquitinates Mdm4, another inhibitor of p53 activity."
24488925
reach
"Additionally, Mdm2, MdmX and p53 can be deubiquitinated by the HAUSP (herpesvirus associated ubiquitin specific protease) protein."
28690977
reach
"Importantly, HAUSP can deubiquitinate MDM2, MDMX, and p53."
25808808
reach
"MdmX phosphorylation (A38) inhibits (A40) the deubiquitination (A39) of MdmX by Hausp, which in turn increases ubiquitinated MdmX showing coherent regulation by DNA damage induced kinases."
20174603
reach
"HAUSP can also deubiquitinate and stabilize MdmX and has a role in DNA damaged induced degradation of MdmX [XREF_BIBR]."
21624367
trips
"Subsequently, HAUSP was shown to deubiquitinate Mdm2 and Mdmx, thereby stabilizing these proteins."
16082221
reach
"Additionally, Wip1 inhibits p53 through MdmX and enhances the interaction of MdmX with ubiquitin specific peptidase 7 (USP7), which deubiquitinates and stabilizes MdmX."
22201816
signor
"Subsequently, hausp was shown to deubiquitinate mdm2 and mdmx, thereby stabilizing these proteins."
16082221
USP7 affects HIF1A
1 | 9
USP7 deubiquitinates HIF1A. 9 / 9
1 | 8
reach
"Beyond, USP7 deubiquitinates and stabilizes HIF1alpha, PHF8 could regulate HIF1alpha through USP7 [XREF_BIBR]."
28734980
reach
"K63 polyubiquitinated HAUSP deubiquitinates HIF-1alpha and dictates H3K56 acetylation promoting hypoxia induced tumour progression."
27934968
reach
"Since both HAUSP and HIF-1alpha play a significant role in tumour progression and aggressiveness XREF_BIBR XREF_BIBR, we evaluated whether HAUSP could deubiquitinate HIF-1alpha through interacting with HIF-1alpha."
27934968
reach
"HAUSP interacts with and deubiquitinates HIF-1alpha."
27934968
reach
"These results demonstrate that HAUSP decreases HIF-1alpha ubiquitination through recognizing a consensus sequence located in HIF-1alpha."
27934968
reach
"USP7, also known as HAUSP (herpesvirus associated ubiquitin specific protease), deubiquitinates HIF-1alpha and stabilizes it."
33466790
reach
"The accumulative USP7 resulted in deubiquitylation and stabilization of HIF-1alpha, thereby facilitating resistance to oxaliplatin."
34740372
reach
"Beyond, USP7 deubiquitinates and stabilizes HIF1alpha, PHF8 could regulate HIF1alpha through USP7 [49]."
28734980
ubibrowser
"K63-polyubiquitinated HAUSP deubiquitinates HIF-1a and dictates H3K56 acetylation promoting hypoxia-induced tumour progression."
27934968
USP7 deubiquitinates ubiquitinated HIF1A. 1 / 1
| 1
reach
"In vitro deubiquitination assays using purified polyubiquitinated HIF-1alpha and Flag-HAUSP (wild-type versus K443R mutant) showed that the wild-type HAUSP, but not the K443R mutant, significantly deubiquitinated the polyubiquitinated HIF-1alpha species (XREF_FIG)."
27934968
USP7 affects ERCC6
1 | 8
USP7 deubiquitinates ERCC6. 9 / 9
1 | 8
reach
"While both CSB and UV stimulated scaffold protein A (UVSSA) exhibit a biphasic decrease and recovery upon UV irradiation, only CSB recovery depends on USP7, which physically interacts with and deubiquitinates CSB."
31775559
ubibrowser
"Review"
28031783
reach
"Upon transcription arrest, these factors bind strongly to RNAPII, and USP7 deubiquitinates CSB to stabilize it."
27549370
reach
"Upon transcription arrest, these factors bind strongly to RNAPII, and USP7 deubiquitylates CSB to stabilize it."
24751236
reach
"Additional factors continue to be identified : Examples include NEDD4, that is implicated in DNA damage induced ubiquitination of the RNA polymerase II subunit RPB1 to mark it for proteosomal degradation; UVSSA and USP7 that bind to RNAPII upon transcription arrest and deubiquitinate CSB to prevent its degradation; and the SPT16 FACT chromatin remodeler."
26255937
reach
"Upon transcription arrest, these factors bind strongly to RNAPII, and USP7 deubiquitylates CSB to stabilize it."
26388429
reach
"To avoid premature degradation of CSB, UVSSA, which binds firmly to stalled RNA pol II, recruits USP7, an enzyme that promotes deubiquitination of CSB, highlighted in blue in XREF_FIG."
32453336
reach
"Here, we demonstrate that USP7 deubiquitinates CSB to maintain its levels after ultraviolet (UV)-induced DNA damage."
31775559
reach
"Additional factors continue to be identified : Examples include NEDD4, that is implicated in DNA damage induced ubiquitination of the RNA polymerase II subunit RPB1 to mark it for proteosomal degradat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26255937
USP7 affects RNF2
1 | 7
USP7 deubiquitinates RNF2. 7 / 7
1 | 6
reach
"In order to confirm that USP7 mediates the deubiquitination of RING1B, we added to self ubiquitinated RING1B bacterially expressed purified His 6 -USP7 and its inactive mutant His 6 -USP7 C223S."
20800574
reach
"Although, USP7 directly and specifically deubiquitinates RING1B in vitro and in vivo, it does not discriminate between the activating and proteolysis targeting modes of ubiquitination, and therefore has a stabilizing effect on RING1B."
20800574
reach
"USP7 deubiquitinates ubiquitinated (by itself or external ligase such as E6AP) RING1B ligase of the polycomb complex [XREF_BIBR]."
28031783
ubibrowser
"Here we identify USP7 as a deubiquitinating enzyme that regulates the ubiquitination state of RING1B."
20800574
reach
"Taken together, these data indicate that USP7 specifically deubiquitinates RING1B in vitro."
20800574
reach
"As shown in Fig. 4 C, USP7 is not a chain type specific DUB and it can deubiquitinate different lysine based polyubiquitin chains.Based on our observation that USP7 can reverse E6-AP-mediated ubiquiti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20800574
reach
"It is possible that in wild type spermatocytes, USP7 may directly deubiquitinate RNF2 and thus reduce H2A ubiquitination in the XY body."
25634095
USP7 deubiquitinates ubiquitinated RNF2. 1 / 1
| 1
reach
"Taken together, these results suggest that USP7 might regulate the ubiquitinated state and therefore the activity of multiple PcG proteins.Since binding of RING1B to USP7 is partially dependent on its[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20800574
USP7 affects CHEK1
2 | 6
USP7 deubiquitinates CHEK1. 7 / 7
2 | 5
reach
"Mechanistically, LINC02582 interacts with deubiquitinating enzyme ubiquitin specific peptidase 7 (USP7) to deubiquitinate and stabilize checkpoint kinase 1 (CHK1), a critical effector kinase in DNA damage response, thus promoting radioresistance."
31601781
ubibrowser
"Mechanistically, LINC02582 interacts with deubiquitinating enzyme ubiquitin specific peptidase 7 (USP7) to deubiquitinate and stabilize checkpoint kinase 1 (CHK1), a critical effector kinase in DNA damage response, thus promoting radioresistance."
31601781
reach
"LncRNA LINC02582 could promote breast cancer radioresistance by interacting with deubiquitinating enzyme ubiquitin specific peptidase 7 (USP7) to deubiquitinate and stabilize checkpoint kinase 1 (CHK1), a key molecule in DDR ."
36323697
ubibrowser
"Review"
27775833
reach
"USP7 purified from 293T cells transfected with USP7 alone decreased CHK1 poly-ubiquitination by 25% in vitro, and USP7 and ZEB1 co-purified from 293T cells with co-transfection of USP7 and ZEB1 reduced CHK1 poly-ubiquitination by 43% (XREF_FIG)."
25086746
reach
"Here we identified ZEB1 as an ATM substrate and the mechanism underlying the association between EMT and radioresistance (XREF_FIG) : in response to IR, ATM kinase is activated, which phosphorylates and stabilizes ZEB1; ZEB1 in turn interacts with and promotes the activity of USP7, which deubiquitinates and stabilizes CHK1."
25086746
reach
"68 HAUSP deubiquitinates checkpoint kinase Chk1, 69 its activator Claspin, 70 and checkpoint with forkhead and RING finger domain protein (Chfr)."
29967688
Mutated USP7 deubiquitinates CHEK1. 1 / 1
| 1
reach
"Importantly, wild type, but not catalytic mutant USP7 can deubiquitinate Chk1 in vivo and in vitro, confirming that USP7 directly regulates Chk1 protein levels."
25483066
USP7 affects TPP1
1 | 6
USP7 deubiquitinates TPP1. 7 / 7
1 | 6
reach
"Because TPP1 is ubiquitinated and the co-immunoprecipitation data suggested that it is a USP7 substrate, we next tested whether USP7 indeed deubiquitinates TPP1."
25172512
reach
"Together, these data indicate that USP7 deubiquitinates TPP1."
25172512
reach
"Addition of USP7 (WT)-3xFLAG but not USP7 (C223S)-3xFLAG reduced TPP1 ubiquitination (XREF_FIG C, lanes 5 and 6), confirming that TPP1 is a USP7 substrate."
25172512
reach
"We identify amino acids in TPP1 and USP7 that are critical for their interaction and multiple lysines within TPP1 that are oligo ubiquitinated and deubiquitinated by USP7."
25172512
reach
"Therefore, both in vivo and in vitro evidence indicates that TPP1 is deubiquitinated by USP7."
25172512
reach
"TPP1 Is Deubiquitinated by USP7."
25172512
ubibrowser
"Review"
27775833
USP7 affects SPRTN
| 7
USP7 deubiquitinates SPRTN. 6 / 6
| 6
reach
"USP7 deubiquitinase deubiquitinates SPRTN upon DPC induction, antagonizing the autocatalytic cleavage and subsequent inactivation of SPRTN."
33567341
reach
"Upon DPC induction, SPRTN is deubiquitinated by USP7, promoting SPRTN stability."
33567341
reach
"Upon formaldehyde treatment and other yet to be identified signals, SPRTN is deubiquitinated by USP11 (this study), USP7, and VCPIP1."
33567341
reach
"USP7 deubiquitylates SPRTN upon DPC induction."
33348378
reach
"Recently, it was shown that USP7 deubiquitinates SPRTN, preventing SPRTN auto-cleavage upon DPC induction."
33567341
reach
"showed that deubiquitination of SPRTN by USP7 does not govern SPRTN localization on chromatin."
33567341
Modified USP7 leads to the deubiquitination of SPRTN. 1 / 1
| 1
reach
"Furthermore, deubiquitylation of SPRTN induced by overexpression of USP7 WT, but not of catalytically inactive USP7 CS, leads to reduced formation of autocatalytic SPRTN fragments."
33348378
USP7 affects NFkappaB
| 7
USP7 deubiquitinates NFkappaB. 7 / 7
| 7
reach
"It has been reported that deubiquitination of NF-kappaB by USP7 is essential for TLR- and TNFR induced gene expression [XREF_BIBR], thus USP7 may has a positive feedback in regulating TNFR1 and also circ-DB formation."
30546088
reach
"These findings reveal a unique mechanism controlling NF-kappaB activity and demonstrate that the deubiquitination of NF-kappaB by USP7 is critical for target gene transcription."
23267096
reach
"NFkappaB can be directly deubiquitinated by HAUSP 87 or can be indirectly regulated by deubiquitination of its upstream factors, such as TRAF6, 24 NEMO (IKK-gamma) XREF_BIBR, XREF_BIBR (HSCARG interacts with NEMO to suppress its polyubiquitination by recruiting HAUSP 91), NIMA (Never In Mitosis Gene A)-related kinase 2 (Nek2), a centrosomal serine/threonine kinase (HAUSP stabilizes Nek2 leading to activation of NFkappaB pathway in multiple myeloma)."
29967688
reach
"USP7 deubiquitination of NF-kappaB leads to increased transcription."
23267096
reach
"Therefore, USP7 's deubiquitination of NF-kappaB enhances pro cytokine production when induced by the TLR signaling pathway."
33138315
reach
"This analysis reveals a significant and selective inhibition of NF-kB target gene expression following TLR4 activation and strongly supports the inhibition of USP7 deubiquitination of NF-kB as a potential therapeutic strategy."
32587091
reach
"Moreover, USP7 deubiquitination of NF-kappaB subunits leads to the increase of transcriptional activity, suggesting this may be the mechanism by which P22077 inhibits H 2 O 2 -induced USP7 mRNA expression."
33584299
USP7 affects CHFR
1 | 6
USP7 deubiquitinates CHFR. 7 / 7
1 | 6
reach
"For example, USP7 mediates the deubiquitination of the checkpoint protein CHFR."
33967786
ubibrowser
"Review"
27775833
reach
"It is reported that USP7 can mediate the deubiquitination of CHFR protein, and the E3 enzyme activity of CHFR protein can target Aurora-A kinase for ubiquitination-dependent protein degradation."
33967786
reach
"Thus, we examined whether USP7 can mediate the deubiquitination of Chfr in vivo."
17442268
reach
"These results demonstrate that USP7 preferentially functions in deubiquitination of Chfr, and prevents autoubiquitination mediated degradation of Chfr.The present study has demonstrated that Chfr bind[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17442268
reach
"Deubiquitination of Chfr, a checkpoint protein, by USP7 and HAUSP regulates its stability and activity."
17442268
reach
"Ubiquitin specific protease, USP7 and HAUSP deubiquitinates CHFR and prevents its degradation, resulting in the increased stability [9]."
20388495
USP7 affects PCNA
1 | 5
USP7 deubiquitinates PCNA. 6 / 6
1 | 5
reach
"Whereas Rad6/Rad18 E2 conjugate/E3 ligase cause PCNA monoubiquitination, Usp1 and Usp7 cause PCNA deubiquitination with some difference in case of HU (Niimi et al, 2008; Fox et al, 2011)."
34272328
reach
"Cell-cycle-synchronization analyses revealed that USP7 suppression increased H2O2 induced PCNA ubiquitination throughout interphase, whereas USP1 suppression specifically increased ubiquitination in S-phase cells."
26673319
reach
"USP7 can deubiquitinate PCNA alongside a related DUB, USP1."
35005106
ubibrowser
"Review"
28031783
reach
"Kashiwaba et al. have additionally shown that USP7 can deubiquitylate PCNA, but this is not coupled to DNA replication and likely plays a role in DNA repair."
29357069
reach
"Surprisingly, USP7 also deubiquitylates PCNA."
27242895
USP7 affects IKBKG
1 | 5
USP7 deubiquitinates IKBKG. 5 / 5
1 | 4
ubibrowser
"Review"
27775833
reach
"Cytoplasmic USP7 binds to and deubiquitinates TRAF6 and IKKgamma, thus terminating TLR mediated NF-kappaB and JNK activation."
18952891
reach
"The aforementioned data demonstrated that both HSCARG and USP7 inhibit NEMO polyubiquitination, and suppression of NEMO polyubiquitination by HSCARG is dependent on USP7."
24832601
reach
"To determine whether USP7 deubiquitinated NEMO polyubiquitination, we examined and compared the levels of NEMO polyubiquitination in HEK 293T cells with or without ectopic USP7."
24832601
reach
"Inhibition of NEMO polyubiquitination by USP7 suggested that USP7 probably inhibited cytokine induced NF-kappaB activation."
24832601
Modified USP7 leads to the deubiquitination of IKBKG. 1 / 1
| 1
reach
"As expected, the results of ubiquitin conjugation assays showed that overexpression of USP7 strongly inhibited polyubiquitination of NEMO (XREF_FIG, XREF_SUPPLEMENTARY)."
24832601
USP7 affects AXIN
| 6
USP7 leads to the deubiquitination of AXIN. 6 / 6
| 6
reach
"USP7 promotes deubiquitination and stabilization of Axin."
31519875
reach
"Coexpression of USP7 suppressed either RNF146 or SIAH1-induced poly-ubiquitination of Axin (Supplementary Fig. 3d)."
31519875
reach
"Deubiquitination of Axin mediated by USP7 prevents Axin from degrading and providing stability."
32486158
reach
"Lei Ji et al. showed that USP7 inhibited Wnt/β-catenin by interacting with Axin TRAF domains and promoting the de-ubiquitination and stabilization of Axin 28."
34539900
reach
"These results suggest that polyubiquitinated Axin1, but not β-catenin, is an efficient substrate of USP7.Since USP7 knockout promotes Wnt-induced Axin degradation (Fig. 3d, e), we next examined whether USP7 knockout affects Wnt-induced Axin ubiquitination."
31519875
reach
"USP7 directly interacts with Axin through its TRAF domain, and promotes deubiquitination and stabilization of Axin."
31519875
USP7 affects ANXA1
| 6
USP7 deubiquitinates ANXA1. 6 / 6
| 6
reach
"These data suggest that deubiquitination of ANXA1 by HAUSP is essential for the UV induced damage response function of ANXA1 in Jurkat cells."
25695607
reach
"Deubiquitination of ANXA1 by HAUSP regulates UV induced damage response in HeLa cells."
25695607
reach
"In this regard, we suggest that deubiquitination of ANXA1 by HAUSP is essential for UV induced damage responsive function of ANXA1."
25695607
reach
"The result showed that HAUSP could reduce the ANXA1 ubiquitination level more upon UV, possibly due to the increase in HAUSP-ANXA1 binding."
25695607
reach
"Collectively, our data suggest that the deubiquitination of ANXA1 is specifically mediated by HAUSP, and HAUSP mediated deubiquitination of ANXA1 may be important for ANXA1 's damage response function in the nucleus upon UV."
25695607
reach
"In this regard, our result of immunofluorescence analysis in HAUSP KD HeLa cells, which showed translocation of nuclear ANXA1 to the cytosol (XREF_FIG), may be due to the failure of deubiquitination of ANXA1 mediated by HAUSP."
25695607
USP7 affects XPC
1 | 4
USP7 deubiquitinates XPC. 5 / 5
1 | 4
reach
"Other proteins involved in the stabilization of XPC might be the deubiquitylating enzymes OTUD4 and USP7, which were shown to deubiquitylate XPC upon UV induced DNA damage XREF_BIBR XREF_BIBR."
26151477
ubibrowser
"Review"
28031783
reach
"Both XPC and CSB also appear to be deubiquitylated by USP7 30, 39, 40 (see below) and regulated by SUMOylation 37, 41, further underscoring the analogies (Figure 2)."
29699641
reach
"Inhibition of USP7 increases XPC ubiquitination level, and without USP7, cells have decreased efficiency in repairing UV lesions [XREF_BIBR, XREF_BIBR]."
30831436
reach
"Specifically, UV induced XPC proteasomal degradation occurs without protection by USP7 which deubiquitinates XPC."
27696486
USP7 affects Poleta
| 5
USP7 deubiquitinates Poleta. 5 / 5
| 5
reach
"USP7 deubiquitinates and stabilizes Poleta."
25435364
reach
"Conversely, overexpression of USP7, directly reducing the polyubiquitination of Poleta mediated by Mdm2, also leads to Poleta stability."
25435364
reach
"USP7 can directly deubiquitinate and stabilize Poleta in cells."
25435364
reach
"An in-depth analysis revealed that USP7 deubiquitinates and stabilizes Poleta through direct protein protein interaction."
25435364
reach
"As shown in XREF_FIG, the levels of polyubiquitinated Poleta decreased gradually in a dose dependent manner by increasing the concentration of recombinant USP7, suggesting that deubiquitination of Poleta is mediated by USP7."
25435364
USP7 affects DAXX
1 | 4
USP7 deubiquitinates DAXX. 5 / 5
1 | 4
reach
"Furthermore, Hausp de-ubiquitinated Daxx and regulated stability of endogenous Daxx."
20153724
ubibrowser
"Review"
27775833
reach
"Similar to what has been reported with Mdm2 and p53, Hausp strongly de-ubiquitinated Daxx (XREF_FIG)."
20153724
reach
"The strong interaction between Daxx and Hausp, and that Daxx is ubiquitinated by Mdm2 and other E3s suggest that Hausp might de-ubiquitinate Daxx."
20153724
reach
"Daxx is deubiquitinated by Hausp."
20153724
USP7 affects CSH2
| 5
USP7 deubiquitinates CSH2. 5 / 5
| 5
reach
"Both XPC and CSB also appear to be deubiquitylated by USP7 30, 39, 40 (see below) and regulated by SUMOylation 37, 41, further underscoring the analogies (Figure 2)."
29699641
reach
"The USP7 physically interacts and deubiquitinates CSB in vivo as well as in vitro [120]."
33991872
reach
"Importantly, the ubiquitin protease USP7 might work with UVSSA to deubiquitylate CSB and suppress its degradation."
29699641
reach
"3.1.2 Deubiquitination of CSB by USP7 in TC-NER."
33991872
reach
"The deubiquitination of CSB by USP7 has indeed been confirmed by several recent studies [92, 120]."
33991872
USP7 affects CLSPN
1 | 4
USP7 deubiquitinates CLSPN. 5 / 5
1 | 4
reach
"Because extracts from mitotic cells readily support ubiquitylation of Claspin in a betaTrCP dependent fashion, we used such an approach to test whether USP7 directly deubiquitylates Claspin in vitro."
19124652
reach
"In contrast, little if any effect on Claspin stability was evident in cells expressing USP7 CI (XREF_FIG), which supports the idea that Claspin is deubiquitylated by USP7."
19124652
reach
"In such experiments, USP7 CI interacted more strongly with endogenous Claspin than did WT USP7 (XREF_FIG), which is consistent with a substrate trapping mechanism in which an inability of inactive USP7 to deubiquitylate Claspin would manifest as a prolonged binding and thus a tighter interaction."
19124652
ubibrowser
"Review"
27775833
reach
"68 HAUSP deubiquitinates checkpoint kinase Chk1, 69 its activator Claspin, 70 and checkpoint with forkhead and RING finger domain protein (Chfr)."
29967688
USP7 affects UHRF1
1 | 3
USP7 deubiquitinates UHRF1. 3 / 3
1 | 2
ubibrowser
"Review"
27775833
reach
"Indeed, USP7 mediates deubiquitylation of UHRF1, preventing its proteasomal degradation."
31492965
reach
"Both UHRF1 and DNMT1 are deubiquitinated and stabilized by USP7 [XREF_BIBR, XREF_BIBR], while UHRF1 is the negative regulator of DNMT1 [XREF_BIBR]."
26046769
USP7 leads to the deubiquitination of UHRF1-K659E. 1 / 1
| 1
reach
"In contrast, USP7 can not reduce the autoubiquitination of the UHRF1 K659E mutant."
26299963
USP7 affects RB1
1 | 3
USP7 deubiquitinates RB1. 4 / 4
1 | 3
reach
"In addition to stabilization of MDM2 by HAUSP, it might be possible that HAUSP reverses Rb ubiquitination by MDM2 in normal cells but is overwhelmed by abundant MDM2 in the case of tumor tissues or cancer cells."
24823443
reach
"HAUSP deubiquitinates Rb in vivo and in vitro, leading to an increased cell population in the G1 phase."
24823443
reach
"HAUSP deubiquitinates Rb."
24823443
ubibrowser
"Review"
27775833
USP7 affects RAD18
1 | 3
USP7 deubiquitinates RAD18. 4 / 4
1 | 3
reach
"USP7 deubiquitinates RAD18 which leads to stabilisation and up-regulation of PCNA ubiquitination."
35005106
ubibrowser
"?Here, we identify the de-ubiquitylating enzyme USP7 as a critical regulator of Rad18 protein levels. Loss of USP7 destabilizes Rad18 and compromises UV-induced PCNA mono-ubiquitylation and Pol 畏 recruitment to stalled replication forks.?"
25961918
reach
"In response to replication stress, USP7 also deubiquitylates and stabilizes both Rad18 (so that it can monoubiquitylate PCNA) and the TLS polymerase, polymerase eta (POL-eta), and this facilitates the bypass of lesions through the error-prone TLS pathway."
29357069
reach
"This is likely concomitant with Pol eta deubiquitination by USP7 and PIAS1 and Rad18 dependent SUMOylation [XREF_BIBR, XREF_BIBR] (XREF_FIG A)."
28067843
USP7 affects Pol iota
| 4
USP7 deubiquitinates Pol iota. 3 / 3
| 3
reach
"Interestingly, USP7 effectively deubiquitinates Pol iota, even though it can be monoubiquitinated at 27 dispersed lysine residues."
33279577
reach
"Pol iota was readily deubiquitinated by USP7 in this assay."
33279577
reach
"We also tested whether USP7 might promote the deubiquitination of Pol iota in cells."
33279577
Mutated USP7 deubiquitinates Pol iota. 1 / 1
| 1
reach
"11 Indeed, a USP7 mutant lacking 19 amino acids from its C-terminus (Delta19 amino acid tail), was also unable to efficiently deubiquitinate Pol iota (XREF_FIG)."
33279577
USP7 affects PHF8
1 | 3
USP7 leads to the deubiquitination of PHF8. 4 / 4
1 | 3
reach
"For instance, USP7 promotes the deubiquitination and stabilization of PHF8 [13]."
29330049
reach
"showed that USP7 promotes deubiquitination and stabilization of PHF8 in breast cancer MCF7 cells, accounting for a mechanism underlying PHF8 deregulation."
27899639
ubibrowser
"Here, we report that PHF8 physically associates with the deubiquitinase USP7."
27183383
reach
"Specifically, we demonstrated that USP7 promotes deubiquitination and stabilization of PHF8, leading to the upregulation of a group of genes, including cyclin A2, that are critical for cell growth and proliferation."
27183383
USP7 affects Nrf1a
| 4
USP7 deubiquitinates Nrf1a. 4 / 4
| 4
reach
"USP7 promotes deubiquitination of TCF11 and Nrf1a."
33933455
reach
"These results show that USP7 is able to stimulate deubiquitination of TCF11 and Nrf1a in cells and support the idea that USP7 regulates the stability of Nrf1 proteins through USP7 deubiquitinase activity."
33933455
reach
"In contrast, knockdown or pharmacologic inhibition of USP7 dramatically increased ubiquitination of TCF11 and Nrf1a and reduction of their steady state levels."
33933455
reach
"To verify that USP7 deubiquitinates TCF11 and Nrf1a specifically, HEK293 cells were transfected with TCF11-V5 or Nrf1a-V5 and HA-tagged ubiquitin along with increasing amounts of Flag-tagged USP7, or USP7-CS, a dominant negative catalytically inactive form of USP7."
33933455
USP7 affects NFE2L1
| 4
USP7 deubiquitinates NFE2L1. 4 / 4
| 4
reach
"In contrast, knockdown or pharmacologic inhibition of USP7 dramatically increased ubiquitination of TCF11 and Nrf1a and reduction of their steady state levels."
33933455
reach
"USP7 promotes deubiquitination of TCF11 and Nrf1a."
33933455
reach
"To verify that USP7 deubiquitinates TCF11 and Nrf1a specifically, HEK293 cells were transfected with TCF11-V5 or Nrf1a-V5 and HA-tagged ubiquitin along with increasing amounts of Flag-tagged USP7, or USP7-CS, a dominant negative catalytically inactive form of USP7."
33933455
reach
"These results show that USP7 is able to stimulate deubiquitination of TCF11 and Nrf1a in cells and support the idea that USP7 regulates the stability of Nrf1 proteins through USP7 deubiquitinase activity."
33933455
USP7 affects NEK2
| 4
USP7 deubiquitinates NEK2. 4 / 4
| 4
reach
"USP7 interacts with and deubiquitinates NEK2."
33754007
reach
"Next we examined whether the increase in NEK2 protein levels was dependent upon the deubiquitinating enzymatic activity of USP7, and found that ectopic expression of USP7 decreased NEK2 ubiquitination."
33754007
reach
"Studies have shown that USP7 deubiquitinates NEK2 and affects its stability XREF_BIBR."
33754007
reach
"We therefore examined whether USP7 deubiquitinated NEK2 and affected its function in PAs, and confirmed a specific interaction between USP7 and NEK2 in transiently transfected HEK293T cells using co-immunoprecipitation."
33754007
USP7 affects MYCN
1 | 3
USP7 deubiquitinates MYCN. 4 / 4
1 | 3
ubibrowser
"HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma"
27618649
reach
"HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma."
27618649
reach
"HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma."
29056421
reach
"The ubiquitin specific peptidase HAUSP (also known as USP7) binds to and deubiquitinates MYCN leading to its stabilization (XREF_FIG)."
33628735
USP7 affects IRS-1/2
| 4
USP7 deubiquitinates IRS-1/2. 4 / 4
| 4
reach
"These results clearly indicate that the rapid dissociation of USP7 from IRS-1/2 in response to insulin and IGF-I stimulation may enable the subsequent ubiquitination and proteasomal degradation of IRS[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22634009
reach
"We hypothesized that USP7 deubiquitinates IRS-1/2 and prevents their proteasomal degradation."
22634009
reach
"Furthermore, we have recently reported that a deubiquitinase, USP7 deubiquitinates IRS-1/2, resulting in their stabilization [XREF_BIBR]."
30338032
reach
"Based on our results, USP7 deubiquitinated IRS-1/2 resulting in increase in their stabilization."
22634009
USP7 affects FOXO4
1 1 | 2
USP7 deubiquitinates FOXO4. 3 / 3
1 | 2
reach
"USP7 negatively regulates FOXO by antagonizing FOXO4 monoubiquitylation and activity without affecting protein stability."
26154057
reach
"USP7 modulates this activity by deubiquitinating FOXO4, causing nuclear export (232)."
34391779
ubibrowser
"Review"
27775833
USP7 deubiquitinates FOXO4 on lysine. 1 / 1
1 |
biopax:pid
No evidence text available
16964248
USP7 affects E3_Ub_ligase
| 4
USP7 deubiquitinates E3_Ub_ligase. 4 / 4
| 4
reach
"Interestingly, USP7 can deubiquitinate both p53 and its negative regulator HDM2, an E3 ubiquitin ligase responsible for polyubiquitination and subsequent degradation of p53."
30807924
reach
"USP7 deubiquitinates the E3 ubiquitin ligase NEDD4L, which mediates the degradation of SMAD2."
33106424
reach
"USP7 deubiquitinates several tumour suppressors (p53, PTEN, FOXO and claspin) and E3 ligases (MDM2, Mule and viral proteins ICP0) and therefore regulates important signalling pathways that are involved in tumorigenesis XREF_BIBR XREF_BIBR."
25960197
reach
"XREF_BIBR - XREF_BIBR USP7 deubiquitinates and stabilizes not only p53, but also Mdm2, the primary E3 ubiquitin ligase of p53 XREF_BIBR, XREF_BIBR Given that both p53 and Mdm2 are known regulators of the steady-level of Poleta, we speculated that changes in cellular USP7 levels may also modulate Poleta level."
25435364
USP7 affects CRYL1
| 4
USP7 deubiquitinates CRYL1. 4 / 4
| 4
reach
"These results demonstrate that USP7 deubiquitinates CRY proteins."
27123980
reach
"USP7 deubiquitinates CRY proteins."
27123980
reach
"Fbxl3 knockdown in HEK293T/17 cells did not abrogate USP7 dependent stabilizing effect on CRY2 (XREF_FIG), suggesting that USP7 deubiquitinates CRY protein that was ubiquitinated by multiple E3 ligases."
27123980
reach
"Given that MAGEL2 interacts with USP7, and that CRY proteins are deubiquitinated and stabilized by USP7, we tested the effect of MAGEL2 and USP7 on the ubiquitination of CRY1."
32315313
USP7 affects CRY1
1 | 3
USP7 deubiquitinates CRY1. 3 / 3
1 | 2
reach
"We then tested whether USP7 can deubiquitinate CRY1."
32315313
ubibrowser
"We found that ubiquitin-specific protease 7 (USP7 also known as HAUSP) associates with CRY1 and CRY2 and stabilizes CRYs through deubiquitination."
27123980
reach
"Recombinant Hausp can deubiquitinate Cry1 in vitro (XREF_FIG)."
25756610
Modified USP7 leads to the deubiquitination of CRY1. 1 / 1
| 1
reach
"CRY1 is ubiquitinated in this assay (XREF_FIG, CRY1 ub smear in lane 2), and co-expression of USP7 reduced CRY1 ubiquitination (ubiquitin smear in lane 3 compared to lane 2)."
32315313
USP7 affects CD274
| 4
USP7 deubiquitinates CD274. 4 / 4
| 4
reach
"In the current study, we show that USP7 deubiquitinates PD-L1 to cause cancer immune resistance to promote cancer growth."
33777676
reach
"Similarly, treatment of MFC cells with mUSP7-sgRNA-lentivirus or Almac4 also led to similar results which further confirm the results derived from XREF_FIG G and H. All these results indicate that USP7 interacts with PD-L1 and deubiquitinates PD-L1 to promote the stability of PD-L1."
33777676
reach
"Results in XREF_FIG E suggest that PD-L1 was strongly ubiquitinated (lane 2, XREF_FIG E) in the presence of MG132 but without HA-USP7, while HA-USP7 abolished PD-L1 ubiquitination (lane3, XREF_FIG E)."
33777676
reach
"Then, to further verify that USP7 can deubiquitinate PD-L1, Flag-PD-L1 was co-transfected with HA-His-Ub in the presence of HA-USP7 or not in HEK293cells."
33777676
USP7 affects BCR-ABL
| 4
USP7 deubiquitinates BCR-ABL. 4 / 4
| 4
reach
"Because the previous study showed that USP7 binds to and deubiquitinates BCR-ABL, we wondered to know whether ART disrupts this interaction."
33963175
reach
"Given that USP7 is a Dub and it stabilizes BCR-ABL, we next wondered whether USP7 could deubiquitinate BCR-ABL."
33963175
reach
"USP7 interacts with and deubiquitinates BCR-ABL."
33963175
reach
"As showed in Fig. 8D, ectopic expression of USP7 significantly reduced BCR-ABL polyubiquitination but it was markedly recovered by ART, suggesting ART acts against USP7."
33963175
USP7 affects AXIN1
1 | 3
USP7 leads to the deubiquitination of AXIN1. 4 / 4
1 | 3
reach
"Consistently, knockout of USP7 in YAPC cells enhanced poly-ubiquitination of endogenous AXIN1 in the TUBE assay (Fig. 3h)."
31519875
reach
"Ubiquitin carboxyl-terminal hydrolase 7 (USP7), a potent negative regulator of Wnt and beta-catenin signaling, promotes the deubiquitination and stabilization of AXIN by interacting with AXIN through its TRAF domain [XREF_BIBR]."
33291655
ubibrowser
"USP7 directly interacts with Axin through its TRAF domain, and promotes deubiquitination and stabilization of Axin."
31519875
reach
"Overexpression of wild-type USP7, but not the C233A mutant, decreased poly-ubiquitination of ectopically expressed Axin1 (Fig. 3g)."
31519875
USP7 affects AR
1 | 3
USP7 deubiquitinates AR. 4 / 4
1 | 3
ubibrowser
"We showed that USP7 associates with AR in an androgen-dependent manner and mediates AR deubiquitination."
26175158
reach
"USP7 deubiquitinates full-length AR, but not AR-V7, in prostate cancer cells, which suggests that the LBD domain of AR may be critical for USP7 recruitment."
30217566
reach
"USP7 mediates AR deubiquitination and associates with AR, in an androgen dependent manner, driving the transcription of target genes and promoting prostate cells growth [XREF_BIBR]."
28415632
reach
"In prostate cancer, USP7 can deubiquitinate and stabilize the androgen receptor in an androgen dependent manner, promoting the androgen receptor binding to chromatin for the transcription of target genes related with cell growth and proliferation (Morra et al., 2017)."
36186590
USP7 affects USP7
| 3
USP7 deubiquitinates USP7. 3 / 3
| 3
reach
"In addition, utilizing the UbiTest analysis we demonstrate that inhibition of USP7 increases polyubiquitination of Foxp3, Tip60 and USP7."
29236775
reach
"However, HAUSP also deubiquitinates MDM2 and reduction of HAUSP levels, either by RNA interference or by gene deletion, produces a complex phenotype [XREF_BIBR - XREF_BIBR]."
24143256
reach
"We also found that SIRT7 enzymatic activity is negatively regulated by ubiquitin-specific-processing protease 7 (USP7)-mediated deubiquitination, which helps control gluconeogenesis by regulating G6PC expression (45)."
30510540
USP7 affects TRAF6
| 3
USP7 deubiquitinates TRAF6. 3 / 3
| 3
reach
"USP15 negatively regulates NFjB activation by deubiquitinating IjB (Harhaj and Dixit 2011) , while USP7 decreases NFkB signalling by deubiquitinating TRAF6 and IKK (Nanduri et al. 2013 )."
30244323
reach
"While in vitro interactions of USP7 NTD with TRAFs 1 to 6, intracellular USP7 binding to TRAFs 4 and 6, and USP7 deubiquitination of TRAF6 have been reported, biological targeting and deubiquitination of the TRAFs by USP7 have generally not been assessed."
31666375
reach
"Cytoplasmic USP7 binds to and deubiquitinates TRAF6 and IKKgamma, thus terminating TLR mediated NF-kappaB and JNK activation."
18952891
USP7 affects SUV39H1
| 3
USP7 deubiquitinates SUV39H1. 3 / 3
| 3
reach
"Collectively, these results indicate that shared physical interactions of USP7 and SUV39H1 with MDM2 are required either for USP7 to deubiquitinate SUV39H1 or for MDM2 to ubiquitinate SUV39H1, both re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26971997
reach
"Collectively, these results indicate that shared physical interactions of USP7 and SUV39H1 with MDM2 are required for either for USP7 to deubiquitinate SUV39H1 or for MDM2 to ubiquitinate SUV39H1; both resulting in enhanced SUV39H1 stability."
26971997
reach
"In the absence of p53, USP7 deubiquitinates SUV39H1 providing protection from MDM2 ubiquitination and USP7, MDM2 and SUV39H1 form a DNA independent trimeric complex.35Finally, the role of US7 in regulation of epigenetic regulators is evidenced by the interaction of USP7 with LSD1."
35005106
USP7 affects RIPK1
1 | 2
USP7 deubiquitinates RIPK1. 3 / 3
1 | 2
ubibrowser
"Review"
27775833
reach
"USP7 also deubiquitinates RIP1 following activation by the TRIM27 E3 ligase resulting in apoptosis."
29479529
reach
"Subsequently, USP7 deubiquitinates the receptor interacting protein 1 (RIP1), resulting in positive regulation of TNF-alpha-induced apoptosis."
24392305
USP7 affects PRC1
1 | 2
USP7 deubiquitinates PRC1. 3 / 3
1 | 2
reach
"In some cancer types, PRC1 can be deubiquitinated by USP7, USP11 and USP26 [XREF_BIBR, XREF_BIBR]."
29142505
ubibrowser
"Review"
29142505
reach
"Lastly, USP7 and USP11 deubiquitinate PRC1, a protein found to contribute to cancer stemness [XREF_BIBR - XREF_BIBR]."
30831436
USP7 affects NOX4
| 3
USP7 deubiquitinates NOX4. 3 / 3
| 3
reach
"USP7 inhibited NOX4 ubiquitination for degradation which leads to elevated ROS production."
33584299
reach
"In summary, this study showed that USP7 deubiquitinates NOX4 to stabilize it, which leads to elevated ROS production."
33584299
reach
"This study showed that USP7 interacted with and deubiquitinated NOX4, and the inhibition of ROS production or administration of NOX4 inhibitor significantly inhibited oeUSP7 induced pro OA effects such as enhanced pyroptosis, elevated ROS level, increased IL-1beta and IL-18 levels, and overexpression of NLRP3, GSDMD-N, active caspase-1, and pro-caspase-1."
33584299
USP7 affects NLRP3
| 3
USP7 deubiquitinates NLRP3. 3 / 3
| 3
reach
"Conversely, deubiquitination of NLRP3 by USP7 and USP47 positively regulates inflammasome activation and USP47 is significantly downregulated in dopaminergic neurons from idiopathic PD patient post-mortem brain samples [XREF_BIBR, XREF_BIBR]."
33414510
reach
"Therefore, H 2 O 2 treatment increases the protein level of NLRP3 and pro-caspase-1 due to the induction of USP7 dependent deubiquitination of NLRP3 and/or activation of NOX4/ROS/NF-kappaB signaling that is capable of DNA binding."
33584299
reach
"However, it is not clear whether USP7 and USP47 directly contribute to NLRP3 deubiquitination or regulate the process somewhere upstream of NLRP3 inflammasome action [108]."
| PMC
USP7 affects MARCHF7
1 | 2
USP7 deubiquitinates MARCHF7. 3 / 3
1 | 2
ubibrowser
"It has been proposed that USP7 may reverse self-ubiquitination of the Ub E3 ligase MARCH7, thus stabilizing MARCH7 which has been known to regulate the expression levels of E-cadherin and β-catenin"
29080116
reach
"Exogenous expression and short interfering RNA depletion experiments demonstrate that MARCH7 can be stabilized by both USP9X and USP7, which deubiquitylate MARCH7 in the cytosol and nucleus, respectively."
18410486
reach
"It has been proposed that USP7 may reverse self ubiquitination of the Ub E3 ligase MARCH7, thus stabilizing MARCH7 which has been known to regulate the expression levels of E-cadherin and beta-catenin."
29080116
USP7 affects KDM1A
1 | 2
USP7 leads to the deubiquitination of KDM1A. 3 / 3
1 | 2
ubibrowser
"Review"
29142505
reach
"USP7 inhibited LSD1 ubiquitination and stabilized LSD1 in A172 and T98G cells."
27632941
reach
"Furthermore, USP7 inhibits LSD1 ubiquitination and stabilizes LSD1in glioma [XREF_BIBR]."
30150556
USP7 affects ICN1
| 3
USP7 deubiquitinates ICN1. 3 / 3
| 3
reach
"In contrast, USP7 inhibition increased ICN1 ubiquitination."
30370059
reach
"As illustrated in Fig. 3e, the purified USP7 markedly reduced the ubiquitination of ICN1."
30370059
reach
"USP7 deubiquitinates ICN1."
30370059
USP7 affects FOXO
| 3
USP7 deubiquitinates FOXO. 3 / 3
| 3
reach
"This process may be reversed by the deubiquitination of FOXO proteins mediated by HAUSP and USP7."
21238503
reach
"Deubiquitination of FOXO requires the deubiquitinating enzyme USP7 and HAUSP (herpesvirus associated ubiquitin specific protease), which interacts with and deubiquitinates FOXO in response to oxidative stress."
16964248
reach
"Deubiquitination of Foxo is mediated by the deubiquitinating enzyme USP7."
21443461
USP7 affects EZH2
| 1 2
USP7 deubiquitinates EZH2. 3 / 3
| 1 2
trips
"USP7 deubiquitinates and stabilizes EZH2 in prostate cancer cells."
32453339
reach
"USP7 deubiquitinates and stabilizes EZH2 in prostate cancer cells."
32453339
reach
"We report here that the PRC2 complex is physically associated with ubiquitin specific protease USP7 in cancer cells where USP7 acts to deubiquitinate and stabilize EZH2."
33849069
USP7 affects ECT2
| 3
USP7 deubiquitinates ECT2. 3 / 3
| 3
reach
"USP7 in turn, deubiquitinates and stabilizes ECT2, resulting in a feedforward regulatory circuit that ultimately sustains the expression of oncogenic protein MDM2."
32929379
reach
"Given that ECT2 is an ubiquitinated protein XREF_BIBR, XREF_BIBR and USP7 promotes the stabilization of ECT2, we next asked the question whether USP7 functions to deubiquitinate ECT2."
32929379
reach
"Specifically, we uncovered that ECT2 and USP7 form a positive feedback loop, in which ECT2 promotes USP7 intermolecular self association, -deubiquitination and -stabilization, and reciprocally, USP7 deubiquitinates and stabilizes ECT2."
32929379
USP7 affects CDC25A
| 3
USP7 deubiquitinates CDC25A. 3 / 3
| 3
reach
"Furthermore, in a co-immunoprecipitation assay, we found that HAUSP interacts with and deubiquitinates Cdc25A both exogenously and endogenously."
32860838
reach
"These data support that BRE upregulation facilitates deubiquitylation of CDC25A in the presence of DNA damage by USP7."
29416040
reach
"USP7 also deubiquitinates the cell cycle checkpoint CDC25A upon DNA damage in the BRCA deficient cells and contributes to cell survival despite the loss of BRCA mediated genome integrity."
30807924
USP7 affects ARMC5
| 3
USP7 leads to the deubiquitination of ARMC5. 3 / 3
| 3
reach
"Silencing of USP7 enhanced ARMC5 ubiquitination and accelerated cell cycle G1/S, subsequently promoted RCC cell proliferation."
33544460
reach
"Conversely, overexpression of USP7, but not its catalytically mutant, reversed ARMC5 ubiquitination levels."
33544460
reach
"Silencing of USP7 decreased ARMC5 levels, accompanied by increasing ARMC5 polyubiquitination, whereas overexpression of USP7 but not its mutants increased ARMC5 levels and reversed ARMC5 polyubiquitination."
33544460
USP7 affects washc1
| 2
USP7 deubiquitinates washc1. 2 / 2
| 2
reach
"Taken together, these results suggest that USP7 limits overproduction of endosomal F-actin by WASH through its ability to deubiquitinate WASH and that precise endosomal F-actin levels are critical for[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26365382
reach
"Taken together, these results suggest that USP7 limits overproduction of endosomal F-actin by WASH through its ability to deubiquitinate WASH (XREF_FIG) and that precise endosomal F-actin levels are critical for proper endosomal protein recycling."
26365382
USP7 affects tat
| 2
USP7 leads to the deubiquitination of tat. 2 / 2
| 2
reach
"USP7 has also been shown to promote HIV-1 infection by deubiquitylating and stabilizing the HIV-1 Tat protein 73."
30367141
reach
"Finally, besides its role in infections mediated by Herpesviruses, USP7 also promotes adenoviral replication via interaction with viral multifunctional protein E1B-55K and enhances HIV viral production by deubiquitinating its Tat protein."
30807924
USP7 affects Wnt
| 2
USP7 deubiquitinates Wnt. 2 / 2
| 2
reach
"31 HAUSP in complex with RNF220 deubiquitinates beta-catenin-enhancing canonical Wnt signaling."
29967688
reach
"Collectively, we concluded that the USP7 mediated beta-catenin deubiquitination and Wnt activation are specific to CRCs carrying APC mutations and are p53 independent."
29045831
USP7 affects UBE2E1
1 | 1
USP7 leads to the deubiquitination of UBE2E1. 2 / 2
1 | 1
ubibrowser
"UbE2E1/UbcH6 is an E2 ubiquitin-conjugating enzyme that is regulated by USP7."
28073915
reach
"We show that USP7 attenuates UbE2E1 mediated ubiquitination, an effect that requires the N-terminal ASTS sequence of UbE2E1 as well as the catalytic activity of USP7."
23603909
USP7 affects TRIM27
1 | 1
USP7 deubiquitinates TRIM27. 2 / 2
1 | 1
ubibrowser
"Our findings suggest that USP7 acts as a negative regulator in antiviral signaling by stabilizing TRIM27 and promoting the degradation of TBK1."
29688809
reach
"First, USP7 deubiquitinates TRIM27 to prevent its own auto-degradation and thus stabilizes the complex."
28626083
USP7 affects TRAF4
| 2
USP7 deubiquitinates TRAF4. 2 / 2
| 2
reach
"USP7 mediates TRAF4 deubiquitination to facilitate the malignant phenotype of ovarian cancer via the RSK4/PI3K/AKT axis."
37006049
reach
"TRAF4 is deubiquitinated and stabilized by USP7, whereas RSK4 is negatively regulated by TRAF4."
37006049
USP7 affects SVIL
| 1 1
USP7 deubiquitinates SVIL. 2 / 2
| 1 1
reach
"USP7 binds directly to the supervillin N terminus and can deubiquitinate and stabilize supervillin."
23382381
trips
"USP7 binds directly to the supervillin N terminus and can deubiquitinate and stabilize supervillin."
23382381
USP7 affects SLC9A3
| 2
USP7 deubiquitinates SLC9A3. 2 / 2
| 2
reach
"Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of human NHE3 regulating its expression and activity."
33095475
reach
"Knockdown of either USP7 or USP10 increased ubiquitination level of NHE3, demonstrating that these proteins deubiquitinate NHE3."
33095475
USP7 affects SAMHD1
| 2
USP7 deubiquitinates SAMHD1. 2 / 2
| 2
reach
"These findings suggest that de-ubiquitination of SAMHD1 by USP7 promotes DDR to overcome oncogenic stress and affect chemotherapy sensitivity."
37081042
reach
"De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity."
37081042
USP7 affects RELA
1 | 1
USP7 deubiquitinates RELA. 2 / 2
1 | 1
reach
"However, USP7 deubiquitinates the NF-kappaB p65 subunit, which is an important regulator of inflammation, but the USP7 inhibitor targets all the substrates of USP7, not only p65."
33138315
ubibrowser
"Review"
25121098
USP7 affects RAUL
| 2
USP7 deubiquitinates RAUL. 1 / 1
| 1
reach
"We then examined whether Usp7 can directly deubiquitinate RAUL in a purified protein system."
21167755
Modified USP7 leads to the deubiquitination of RAUL. 1 / 1
| 1
reach
"As shown in XREF_FIG, a large amount of conjugated RAUL was detected in cells transfected with RAUL and HA-Ub; however, RAUL ubiquitination was completely abolished by Usp7 expression, and the Usp7 catalytically inactive mutant Usp7-cs failed to deubiquitinate RAUL."
21167755
USP7 affects RAF1
| 2
USP7 deubiquitinates RAF1. 2 / 2
| 2
reach
"In summary, our results indicate that USP7 deubiquitinates Raf-1 and is a new regulator of the ERK1/2 signaling pathway in lung adenocarcinoma."
35948545
reach
"USP7 regulates the ERK1/2 signaling pathway through deubiquitinating Raf-1 in lung adenocarcinoma."
35948545
USP7 affects PML
1 | 1
USP7 leads to the deubiquitination of PML. 2 / 2
1 | 1
ubibrowser
"Review"
27775833
reach
"Here we showed that USP7 can also function independently from its deubiquitylating activity to negatively regulate the levels of PML proteins and the formation of PML-NBs, by inducing the polyubiquitylation of PML."
21305000
USP7 affects NOTCH1
| 2
USP7 deubiquitinates NOTCH1. 2 / 2
| 2
reach
"USP7 deubiquitinated NOTCH1 in vivo and in vitro, whereas knockdown of USP7 increased the ubiquitination of NOTCH1."
30370059
reach
"USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia."
30370059
USP7 affects NEDD4L
1 | 1
USP7 deubiquitinates NEDD4L. 2 / 2
1 | 1
ubibrowser
"USP7 deubiquitinates the E3 ubiquitin ligase NEDD4L, which mediates the degradation of SMAD2."
33106424
reach
"USP7 deubiquitinates the E3 ubiquitin ligase NEDD4L, which mediates the degradation of SMAD2."
33106424
USP7 affects NCL
| 2
Modified USP7 leads to the deubiquitination of NCL. 1 / 1
| 1
reach
"Overexpression of wild-type HAUSP, but not a catalytic mutant (C223S) decreased nucleolin ubiquitination (XREF_FIG, lane 3)."
26238070
USP7 leads to the deubiquitination of NCL. 1 / 1
| 1
reach
"Therefore, we examined the pattern of polyubiquitination and deubiquitination of nucleolin following HAUSP overexpression (XREF_FIG)."
26238070
USP7 affects IKK_complex
| 2
USP7 deubiquitinates IKK_complex. 2 / 2
| 2
reach
"USP15 negatively regulates NFjB activation by deubiquitinating IjB (Harhaj and Dixit 2011) , while USP7 decreases NFkB signalling by deubiquitinating TRAF6 and IKK (Nanduri et al. 2013 )."
30244323
reach
"USP15 negatively regulates NFκB activation by deubiquitinating IκB (Harhaj and Dixit 2011), while USP7 decreases NFkB signalling by deubiquitinating TRAF6 and IKK (Nanduri et al. 2013)."
30244323
USP7 affects Histone_H3
| 2
USP7 deubiquitinates Histone_H3. 2 / 2
| 2
reach
"USP7 stabilizes several other histone associated proteins including acetyltransferase TIP60, demethylase PHF8, methyltransferase MLL5, lysine specific demethylase 1 (LSD1 and KDM1), and directly deubiquitinates histone H3."
30807924
reach
"Our results thus suggest that histone H3 deubiquitylation by Usp7 is an important step in the maintenance of DNA methylation."
28246399
USP7 affects HdmX
| 2
USP7 deubiquitinates HdmX. 2 / 2
| 2
reach
"The ability of USP7 to also deubiquitinate and control the turnover of HdmX was recently demonstrated."
20713061
reach
"Apart from p53, USP7 also deubiquitinates and stabilizes Hdm2 and HdmX, which are negative regulators of p53, indicating a complex regulatory mechanism."
25605410
USP7 affects HSD17B8
| 2
USP7 deubiquitinates ubiquitinated HSD17B8. 1 / 1
| 1
reach
"USP7 also deubiquitinates autoubiquitinated RING2 ligase of the polycomb complex and RING2 that has been marked for degradation by the E6AP ligase."
23845989
USP7 deubiquitinates HSD17B8. 1 / 1
| 1
reach
"USP7 also deubiquitinates autoubiquitinated RING2 ligase of the polycomb complex and RING2 that has been marked for degradation by the E6AP ligase."
23845989
USP7 affects HIF1
| 2
USP7 deubiquitinates HIF1. 2 / 2
| 2
reach
"As expected, ectopically expressed USP7 decreased ubiquitination of endogenous HIF-1α, while depletion of USP7 promoted ubiquitination of endogenous HIF-1α (Fig. 5F-G)."
34740372
reach
"The accumulative USP7 resulted in deubiquitylation and stabilization of HIF-1α, thereby facilitating resistance to oxaliplatin."
34740372
USP7 affects HDMX
| 2
USP7 deubiquitinates HDMX. 2 / 2
| 2
reach
"USP7 preferentially deubiquitylates the E3 ligase HDM2 and its binding partner HDMX, resulting in the destabilisation of p53 and the repression of p53 transactivation activity."
22088887
reach
"USP7 preferentially deubiquitylates the E3 ligase HDM2 and its binding partner HDMX as well as their substrate p53 (Brooks et al., 2007; Cummins and Vogelstein, 2004; Li et al., 2002, 2004; Meulmeeste[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22118674
USP7 affects GLI1
1 | 1
USP7 deubiquitinates GLI1. 2 / 2
1 | 1
reach
"HAUSP Deubiquitinates Gli and Promotes Hh Signaling Activity in Mammalian Systems."
26120032
ubibrowser
"Deubiquitination of Ci/Gli by Usp7/HAUSP regulates Hedgehog Signaling"
26120032
USP7 affects FBP1
| 2
USP7 deubiquitinates FBP1. 2 / 2
| 2
reach
"Deubiquitination of FBP1 by USP7 blocks FBP1-DNMT1 interaction and decreases the sensitivity of pancreatic cancer cells to PARP inhibitors."
34854226
reach
"Moreover, we revealed that ubiquitin carboxyl-terminal hydrolase 7 (USP7) binds to and induces the deubiquitination of FBP1, which prevented FBP1 from translocating to the nucleus."
34854226
USP7 affects EDNRA
| 2
USP7 deubiquitinates EDNRA. 2 / 2
| 2
reach
"Pol eta is also deubiquitinated by USP7, leading to the recruitment of PCNA to stalled replication forks and PCNA 's ubiquitination by Rad 6 and Rad18 [XREF_BIBR]."
30897496
reach
"This is likely concomitant with Pol eta deubiquitination by USP7 and PIAS1 and Rad18 dependent SUMOylation [XREF_BIBR, XREF_BIBR] (XREF_FIG A)."
28067843
USP7 affects Cyclin
| 2
USP7 leads to the deubiquitination of Cyclin on A2. 2 / 2
| 2
reach
"The exosomal circ-DB internalized by HCC cells can be used as a molecular sponge to absorb miR-34a endogenously, thereby deinhibiting the downstream target USP7, which inhibits the ubiquitination of cyclin A2 protein to maintain its stability."
33869059
reach
"USP7 mediates the deubiquitination of cyclin A2 in HCC."
30546088
USP7 affects CRY2
1 | 1
USP7 deubiquitinates CRY2. 2 / 2
1 | 1
reach
"Here, we demonstrated that, even in the absence of any DNA damage inducible stimuli, not only CRY1 but also CRY2 binds to USP7 and is deubiquitinated by USP7 (Figs XREF_FIG and XREF_FIG)."
27123980
ubibrowser
"We found that ubiquitin-specific protease 7 (USP7 also known as HAUSP) associates with CRY1 and CRY2 and stabilizes CRYs through deubiquitination."
27123980
USP7 affects BMI1
1 | 1
USP7 leads to the deubiquitination of BMI1. 2 / 2
1 | 1
ubibrowser
"Review"
27919796
reach
"Also, a recent study suggested that USP7 attenuates the ubiquitination of BMI1, its homologue Mel-18, and RING1A, which are components of the PRC1 complex [15]."
20800574
USP7 affects ALKBH3
| 2
USP7 deubiquitinates ALKBH3. 2 / 2
| 2
reach
"Instead, it seemed to act as a scaffold protein, recruiting two further DUBs, USP7 and USP9x, which then de-ubiquitylated ALKBH3."
26588485
reach
"Besides USP11, OTUD4 is another USP7 partner that deubiquitinates DNA demethylases ALKBH2 and ALKBH3 [118]."
33991872
USP7 deubiquitinates transcriptional activator. 1 / 1
| 1
reach
"39 USP7 also deubiquitinates RNA transcriptional activator associated ubiquitin ligase and prevents it from self-ubiquitination-mediated degradation."
24832601
USP7 affects polycomb complex [
| 1
USP7 deubiquitinates polycomb complex [. 1 / 1
| 1
reach
"USP7 deubiquitinates ubiquitinated (by itself or external ligase such as E6AP) RING1B ligase of the polycomb complex [XREF_BIBR]."
28031783
USP7 affects murine double minute-2
| 1
USP7 deubiquitinates murine double minute-2. 1 / 1
| 1
reach
"USP7 deubiquitinates murine double minute-2 (MDM2), an E3 ligase of p53, resulting in p53 degradation."
32196552
USP7 affects double minute 2
| 1
USP7 deubiquitinates double minute 2. 1 / 1
| 1
reach
"With the collaboration of the adapter protein Daxx (death domain associated protein) (Tang et al., 2006), USP7 also deubiquitinates the mouse double minute 2 (MDM2) oncogene, one of several E3s that mediate p53 proteasomal degradation."
17291557
USP7 affects demethylase PHF8
| 1
USP7 leads to the deubiquitination of demethylase PHF8. 1 / 1
| 1
reach
"44 HAUSP promotes deubiquitination and stabilization of the histone demethylase PHF8, leading to the upregulation of a group of genes, including cyclin A2, which are critical for cell growth and proliferation in breast cancer."
29967688
USP7 affects chromatin-associated proteins
| 1
USP7 deubiquitinates chromatin-associated proteins. 1 / 1
| 1
reach
"XREF_BIBR USP7 can deubiquitinate various tumor suppressors (p53, PTEN, FOXO, and claspin), E3 ligases (MDM2 and MDMX and viral protein ICP0), as well as chromatin associated proteins (histone H2B, UHRF1, and Tip60); therefore, it regulates important cellular processes involved in the tumorigenesis."
27051296
USP7 affects androgen
| 1
USP7 deubiquitinates androgen. 1 / 1
| 1
reach
"In prostate cancer, USP7 can deubiquitinate and stabilize the androgen receptor in an androgen dependent manner, promoting the androgen receptor binding to chromatin for the transcription of target genes related with cell growth and proliferation (Morra et al., 2017)."
36186590
USP7 affects YAP1
1 |
USP7 deubiquitinates YAP1. 1 / 1
1 |
ubibrowser
"Furthermore, the mammalian homolog of Usp7, HAUSP plays a conserved role in regulating Hippo pathway by modulating Yap ubiquitination and degradation."
30679505
USP7 affects XPC-ubiquitin
| 1
USP7 deubiquitinates XPC-ubiquitin. 1 / 1
| 1
reach
"Importantly, USP7 efficiently deubiquitinates XPC-ubiquitin conjugates in deubiquitination assays in vitro."
25118285
USP7 affects XIAP
| 1
USP7 deubiquitinates XIAP. 1 / 1
| 1
reach
"Besides, USP7 deubiquitinates the X-linked inhibitor of apoptosis protein (XIAP)."
35800757
USP7 affects UVSSA
1 |
USP7 deubiquitinates UVSSA. 1 / 1
1 |
ubibrowser
"The central region of UVSSA, which contains the tumor necrosis factor receptor-associated factor (TRAF)-binding motif, is required for the interaction with the N-terminal TRAF domain of USP7. Here, we showed that UVSSA is mono-ubiquitinated in?vitro and identified a lysine residue (Lys414?) in UVSSA as the target of ubiquitination. The deubiquitination activity of USP7 was inhibited by the ubiquitin-conjugating enzyme UbcH6. Lys414?was also modified by poly-ubiquitin chains in?vivo.?"
29323787
USP7 affects TRRAP
| 1
USP7 deubiquitinates TRRAP. 1 / 1
| 1
trips
"HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP."
25925205
USP7 affects TRIP12
1 |
USP7 deubiquitinates TRIP12. 1 / 1
1 |
ubibrowser
"Ubiquitin-specific protease 7 accelerates p14(ARF) degradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression"
25557975
USP7 affects TRAFs
| 1
USP7 leads to the deubiquitination of TRAFs. 1 / 1
| 1
reach
"While in vitro interactions of USP7 NTD with TRAFs 1 to 6, intracellular USP7 binding to TRAFs 4 and 6, and USP7 deubiquitination of TRAF6 have been reported, biological targeting and deubiquitination of the TRAFs by USP7 have generally not been assessed."
31666375
USP7 affects TP53BP1
1 |
USP7 deubiquitinates TP53BP1. 1 / 1
1 |
ubibrowser
"53BP1 depletion induces mitotic defects such as disorientation of spindle poles attributed to extra centrosomes or mispositioning of centrosomes, leading to phenotypes similar to those in USP7-deficient cells."
28930533
USP7 affects TOP1-DPC
| 1
USP7 leads to the deubiquitination of TOP1-DPC. 1 / 1
| 1
reach
"Using the modified RADAR assay, we found that USP7 inhibition increased TOP1-DPC ubiquitylation after CPT treatment in the presence of PARGi (Fig. 5e; Supplementary Fig. 5b), suggesting that hyper-PARylation of TOP1-DPC triggers USP7-mediated deubiquitylation of the DPCs."
34408146
USP7 affects TOP1
| 1
USP7 leads to the deubiquitination of TOP1. 1 / 1
| 1
reach
"USP7 reduced the levels of poly-ubiquitylated TOP1 species in a dose-dependent manner (Fig. 5b), confirming the deubiquitylating activity of USP7 against TOP1."
34408146
USP7 affects TIP-60
| 1
USP7 deubiquitinates TIP-60. 1 / 1
| 1
trips
"Here we show that USP7 interacts with and deubiquitinates Tip60 both in vitro and in vivo."
23775119
USP7 affects TBK1
| 1
Modified USP7 leads to the deubiquitination of TBK1. 1 / 1
| 1
reach
"Overexpression of USP7 promoted the ubiquitination and degradation of TBK1 through promoting the stability of TRIM27."
29688809
USP7 affects SYT1
| 1
USP7 leads to the deubiquitination of SYT1. 1 / 1
| 1
reach
"USP7 could inhibit the ubiquitination of P65 and stabilize the expression of P65, thereby promoting the progress of hepatoma cancer [16]."
32002017
USP7 affects SPRYD3
| 1
USP7 deubiquitinates SPRYD3. 1 / 1
| 1
reach
"USP7, which co-IPs with USP11 and can co-IP USP11, RAE1, PAM and SPRYD3 (XREF_SUPPLEMENTARY), efficiently deubiquitinated SPRYD3, whilst RAE1 is only weakly deubiquitinated by USP7 (XREF_FIG)."
29293652
USP7 affects SOX2
| 1
USP7 deubiquitinates SOX2. 1 / 1
| 1
reach
"Mechanistically, USP7 deubiquitinates and stabilizes SOX2 to repress mesoendodermal (ME) lineage genes."
37196079
USP7 affects SIRT7
1 |
USP7 deubiquitinates SIRT7. 1 / 1
1 |
ubibrowser
"Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis"
28655758
USP7 affects SIRT1
| 1
USP7 deubiquitinates SIRT1. 1 / 1
| 1
reach
"USP7 Deubiquitinates and Stabilizes SIRT1."
31502386
USP7 affects RNF6
| 1
USP7 leads to the deubiquitination of RNF6. 1 / 1
| 1
reach
"In contrast, we found a USP7-specific inhibitor promotes RNF6 polyubiquitination, degradation, and cell death."
35926709
USP7 affects RNF220
| 1
USP7 deubiquitinates RNF220. 1 / 1
| 1
reach
"Specifically, USP7 binds the N-terminus of β-catenin when the APC losses CID confirming the essential role of USP7 in the activation of Wnt signalling and cell survival in colorectal cancers.13 Ma et al showed that the USP7/RNF220 complex activates the Wnt pathway while knockdown of USP7 using a small interfering RNA (siRNA) strategy, reduces the expression of Wnt.18 Conversely, a recent study proposed that USP7 deubiquitinates β-catenin and RNF220 independently and works as a tumour-specific condition when APC is mutated."
35005106
USP7 affects RNF168
1 |
USP7 deubiquitinates RNF168. 1 / 1
1 |
USP7 affects RING1
| 1
USP7 leads to the deubiquitination of RING1. 1 / 1
| 1
reach
"His ubiquitin pull-down analysis showed that HSCARG and USP7 inhibited RING1 ubiquitination in a synergy manner."
24711370
USP7 affects RELB
| 1
USP7 deubiquitinates RELB. 1 / 1
| 1
reach
"In contrast, both WT USP7 and USP7DeltaUbl2 were able to deubiquitinate RelB, demonstrating that Ubl2 is dispensable for USP7 interaction with and deubiquitination of RelB (XREF_FIG B)."
32587091
USP7 affects RARA
1 |
USP7 deubiquitinates RARA. 1 / 1
1 |
ubibrowser
"overexpression or depletion of USP37 caused an increase or decrease of PLZF/RARA protein half-life, correlating with down- or upregulation of PLZF/RARA poly-ubiquitination, respectively. By PLZF/RARA-transduced primary mouse hematopoietic progenitor cells, we demonstrated that Usp37 knockdown alleviated PLZF/RARA-mediated target gene suppression and cell transformation potential"
23208507
USP7 affects RAE1
| 1
USP7 deubiquitinates RAE1. 1 / 1
| 1
reach
"USP7, which co-IPs with USP11 and can co-IP USP11, RAE1, PAM and SPRYD3 (XREF_SUPPLEMENTARY), efficiently deubiquitinated SPRYD3, whilst RAE1 is only weakly deubiquitinated by USP7 (XREF_FIG)."
29293652
USP7 affects PPARG
1 |
USP7 deubiquitinates PPARG. 1 / 1
1 |
USP7 affects POU5F1
1 |
USP7 deubiquitinates POU5F1. 1 / 1
1 |
USP7 affects POLH
1 |
USP7 deubiquitinates POLH. 1 / 1
1 |
ubibrowser
"USP7 directly serves as a specific DUB for Poleta"
25435364
USP7 affects PCGF2
| 1
USP7 deubiquitinates PCGF2. 1 / 1
| 1
reach
"Nevertheless, MEL18 and BMI were deubiquitylated by USP7 and USP11, two chromatin bound components of polycomb and repressive complex 1 complex components that influence the transcriptional regulation of p16INK4a [XREF_BIBR]."
25972356
USP7 affects P5091
| 1
USP7 deubiquitinates P5091. 1 / 1
| 1
reach
"Collectively, our studies utilize MM cell lines, patient tumor cells, and MM xenograft models, as well as biochemical and genetic models, to show the anti-tumor activity of a USP7 deubiquitylating enzyme inhibitor P5091."
22975377
USP7 affects NFҡB
| 1
USP7 deubiquitinates NFҡB. 1 / 1
| 1
reach
"86 NFҡB, the master regulator of inflammatory and immune signaling, is also deubiquitinated and stabilized by HAUSP, resulting in increased nuclear localization and hence transcriptional activity."
29967688
USP7 affects NFKB1
1 |
USP7 deubiquitinates NFKB1. 1 / 1
1 |
USP7 affects NF-kB p65
| 1
USP7 deubiquitinates NF-kB p65. 1 / 1
| 1
reach
"We have previously demonstrated that USP7 deubiquitinates NF-kB p65 to promote NF-kB transcriptional responses induced by tumor necrosis factor alpha and TLR ligands."
32587091
USP7 affects MYD88
| 1
USP7 leads to the deubiquitination of MYD88. 1 / 1
| 1
reach
"USP7 Promotes deubiquitination and stabilization of MyD88 to enhance immune responses."
36032091
USP7 affects MYC
1 |
USP7 deubiquitinates MYC. 1 / 1
1 |
ubibrowser
"Most importantly, we are able to demonstrate that USP7 deubiquitinates and thereby stabilizes c-Myc and that this function is required to maintain neural stem cell fate."
29899379
USP7 affects MAFB
| 1
USP7 deubiquitinates MAFB. 1 / 1
| 1
reach
"Stability of MAF proteins in MM is further regulated by the deubiquitinases ubiquitin specific peptidase 5 (USP5), which prevents degradation of c-MAF and MAFB [XREF_BIBR], and USP7, which can deubiquitinate c-MAF, MAFA and MAFB [XREF_BIBR]."
33494394
USP7 affects MAFA
| 1
USP7 deubiquitinates MAFA. 1 / 1
| 1
reach
"Stability of MAF proteins in MM is further regulated by the deubiquitinases ubiquitin specific peptidase 5 (USP5), which prevents degradation of c-MAF and MAFB [XREF_BIBR], and USP7, which can deubiquitinate c-MAF, MAFA and MAFB [XREF_BIBR]."
33494394
USP7 affects MAF
| 1
USP7 deubiquitinates MAF. 1 / 1
| 1
reach
"Stability of MAF proteins in MM is further regulated by the deubiquitinases ubiquitin specific peptidase 5 (USP5), which prevents degradation of c-MAF and MAFB [XREF_BIBR], and USP7, which can deubiquitinate c-MAF, MAFA and MAFB [XREF_BIBR]."
33494394
USP7 affects Ki-67 protein
| 1
Modified USP7 leads to the deubiquitination of Ki-67 protein. 1 / 1
| 1
reach
"Taken together, these data strongly suggest that the overexpression of USP7 might promote cell proliferation by deubiquitinating Ki-67 protein, thereby maintaining its high levels in the non small cell lung cancer."
27590858
USP7 affects KMT2E
| 1
USP7 deubiquitinates KMT2E. 1 / 1
| 1
reach
"To determine whether USP7 deubiquitinates MLL5 protein, we used a lentiviral based shRNA approach to eliminate USP7 expression in HeLa cells, and examined the effects on MLL5 protein."
26678539
USP7 affects KDM6A
| 1
USP7 deubiquitinates KDM6A. 1 / 1
| 1
reach
"USP7 deubiquitinated KDM6A to increase its expression."
34645609
USP7 affects IRS2
1 |
USP7 deubiquitinates IRS2. 1 / 1
1 |
USP7 affects IRS1
1 |
USP7 deubiquitinates IRS1. 1 / 1
1 |
USP7 affects ICP0
| 1
USP7 leads to the deubiquitination of ICP0. 1 / 1
| 1
reach
"47 Similarly, HAUSP blocks ICP0 autoubiquitination 48 and enhances ICP0 protein stability."
22945642
USP7 affects Histone
| 1
USP7 leads to the deubiquitination of Histone. 1 / 1
| 1
reach
"44 HAUSP promotes deubiquitination and stabilization of the histone demethylase PHF8, leading to the upregulation of a group of genes, including cyclin A2, which are critical for cell growth and proliferation in breast cancer."
29967688
USP7 affects Hdmx
| 1
USP7 deubiquitinates Hdmx. 1 / 1
| 1
reach
"Importantly, impaired deubiquitination of Hdmx and Hdm2 by HAUSP contributes to the DNA damage induced degradation of Hdmx and transient instability of Hdm2."
15916963
USP7 affects HUWE1
| 1
USP7 deubiquitinates HUWE1. 1 / 1
| 1
reach
"In addition to its substrates, HUWE1 also mediates selfubiquitination; this is counteracted by Ser18 containing isoform of ubiquitin-specific-processing protease 7 (USP7S) that de-ubiquitinates HUWE1 and prevents its subsequent degradation XREF_BIBR - XREF_BIBR."
29118367
USP7 affects HLTF
1 |
USP7 deubiquitinates HLTF. 1 / 1
1 |
USP7 affects H2BC10
1 |
USP7 deubiquitinates H2BC10. 1 / 1
1 |
USP7 affects GMPS
| 1
Modified USP7 leads to the deubiquitination of GMPS. 1 / 1
| 1
reach
"Of note, USP7 overexpression leads to GMPS deubiquitylation and nuclear retention."
24507714
USP7 affects Fig. 5F-G
| 1
USP7 leads to the deubiquitination of Fig. 5F-G. 1 / 1
| 1
reach
"As expected, ectopically expressed USP7 decreased ubiquitination of endogenous HIF-1α, while depletion of USP7 promoted ubiquitination of endogenous HIF-1α (Fig. 5F-G)."
34740372
USP7 affects FUS
| 1
USP7 deubiquitinates FUS. 1 / 1
| 1
reach
"In response to replication stress, USP7 also deubiquitylates and stabilizes both Rad18 (so that it can monoubiquitylate PCNA) and the TLS polymerase, polymerase eta (POL-eta), and this facilitates the bypass of lesions through the error-prone TLS pathway."
29357069
USP7 affects FOXO3
1 |
USP7 deubiquitinates FOXO3. 1 / 1
1 |
ubibrowser
"USP7 deubiquitinates checkpoint with forkhead and RING finger domains protein (Chfr), which in turn ubiquitinates histone deacetylase 1 (HDAC1), leading to upregulation of p21Cip1/Waf1?and induction of G1 arrest"
25121098
USP7 affects FOXO1
1 |
USP7 deubiquitinates FOXO1. 1 / 1
1 |
USP7 affects ESR
| 1
USP7 deubiquitinates ESR. 1 / 1
| 1
reach
"It was recently suggested that ubiquitin specific protease 7 (USP7) directly deubiquitinates and stabilises ERα in human breast tumour tissue [40]."
34497382
USP7 affects DNMT3B
| 1
USP7 deubiquitinates DNMT3B. 1 / 1
| 1
reach
"FA decreased the ubiquitination of DNMT1 (p = 0.0753), DNMT3A (p = 0.0008) and DNMT3B (p < 0.0001) by decreasing UHRF1 (p < 0.0001) and USP7 (p < 0.0001)."
31060424
USP7 affects DNMT3A
| 1
USP7 deubiquitinates DNMT3A. 1 / 1
| 1
reach
"FA decreased the ubiquitination of DNMT1 (p = 0.0753), DNMT3A (p = 0.0008) and DNMT3B (p < 0.0001) by decreasing UHRF1 (p < 0.0001) and USP7 (p < 0.0001)."
31060424
USP7 affects Ci/Gli
| 1
USP7 deubiquitinates Ci/Gli. 1 / 1
| 1
reach
"Deubiquitination of Ci/Gli by Usp7 and HAUSP regulates Hedgehog Signaling."
26120032
USP7 affects CSH1
| 1
USP7 deubiquitinates CSH1. 1 / 1
| 1
reach
"It is feasible that CSA is no longer de-ubiquitylated by the UVSSA-binding partner USP7 in ELOF1-KO cells."
34108663
USP7 affects CREB3
| 1
USP7 deubiquitinates CREB3. 1 / 1
| 1
reach
"Similarly, USP7 deubiquitination of FOXO4 's monoubiquitinated, transcriptionally active form excludes it from the nucleus, eliminating its activity [XREF_BIBR]."
30897496
USP7 affects CBX4
| 1
USP7 deubiquitinates CBX4. 1 / 1
| 1
reach
"USP7 associates with canonical PRC1 (cPRC1) and deubiquitinates the chromodomain subunits CBX2 and CBX4, and inhibition of USP activity results in disassembly of cPRC1."
37014752
USP7 affects CBX2
| 1
USP7 deubiquitinates CBX2. 1 / 1
| 1
reach
"USP7 associates with canonical PRC1 (cPRC1) and deubiquitinates the chromodomain subunits CBX2 and CBX4, and inhibition of USP activity results in disassembly of cPRC1."
37014752
USP7 affects BUB3
1 |
USP7 deubiquitinates BUB3. 1 / 1
1 |
USP7 affects AURKA
1 |
USP7 deubiquitinates AURKA. 1 / 1
1 |
USP7 affects ARF4
| 1
USP7 leads to the deubiquitination of ARF4. 1 / 1
| 1
reach
"USP7 inhibition induces apoptosis in glioblastoma by enhancing ubiquitination of ARF4."
34556124
USP7 affects AR-V7
| 1
USP7 deubiquitinates AR-V7. 1 / 1
| 1
reach
"USP7 deubiquitinates full-length AR, but not AR-V7, in prostate cancer cells, which suggests that the LBD domain of AR may be critical for USP7 recruitment."
30217566
USP7 affects ALKBH2
| 1
USP7 deubiquitinates ALKBH2. 1 / 1
| 1
reach
"Besides USP11, OTUD4 is another USP7 partner that deubiquitinates DNA demethylases ALKBH2 and ALKBH3 [118]."
33991872
USP7 affects AKT
| 1
USP7 leads to the deubiquitination of AKT on K284. 1 / 1
| 1
reach
"In contrast, the deubiquitinase USP7 inhibits Akt ubiquitination at lysine 284/214 and lysosomal degradation [130]."
34419139