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USP7 deubiquitinates NLRP3. 3 / 3
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"Conversely, deubiquitination of NLRP3 by USP7 and USP47 positively regulates inflammasome activation and USP47 is significantly downregulated in dopaminergic neurons from idiopathic PD patient post-mortem brain samples [XREF_BIBR, XREF_BIBR]."
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"Therefore, H 2 O 2 treatment increases the protein level of NLRP3 and pro-caspase-1 due to the induction of USP7 dependent deubiquitination of NLRP3 and/or activation of NOX4/ROS/NF-kappaB signaling that is capable of DNA binding."
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"However, it is not clear whether USP7 and USP47 directly contribute to NLRP3 deubiquitination or regulate the process somewhere upstream of NLRP3 inflammasome action [108]."
| PMC