IndraLab

Statements

USP7 deubiquitinates NLRP3. 8 / 8
| 8
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"Chemical inhibition of DUBs USP7 and USP47 increases the ubiquitination of NLRP3, prevents PYCARD oligomerization and speck formation, and blocks inflammasome formation [130]."
36551253
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"A previous study revealed that USP7 and USP47 activated NLRP3 inflammasome by regulating ASC oligomerization, NLRP3 ubiquitination, and speck formation in macrophages, but remained unclear whether USP7 and USP47 contributed to NLRP3 deubiquitination directly or indirectly [32]."
38467635
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"Conversely, deubiquitination of NLRP3 by USP7 and USP47 positively regulates inflammasome activation and USP47 is significantly downregulated in dopaminergic neurons from idiopathic PD patient post-mortem brain samples [XREF_BIBR, XREF_BIBR]."
33414510
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"However, it is not clear whether USP7 and USP47 directly contribute to NLRP3 deubiquitination or regulate the process somewhere upstream of NLRP3 inflammasome action [108]."
| PMC
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"Therefore, H 2 O 2 treatment increases the protein level of NLRP3 and pro-caspase-1 due to the induction of USP7 dependent deubiquitination of NLRP3 and/or activation of NOX4/ROS/NF-kappaB signaling that is capable of DNA binding."
33584299
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"A recent study has found that USP7 and USP47 are involved in the activation of inflammasomes in macrophages and play a direct role in the deubiquitination of NLRP3 [69]."
39767641
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"USP7 interacted with NLRP3 and deubiquitinated NLRP3 through K48-ubiquitination."
38467635
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"Both regulate various signaling pathways, such as the inflammasome pathway , WNT signaling , Hedgehog signaling , etc. USP7 and USP47 deubiquitinate NLRP3 and control the assembly and activation of inflammasomes in macrophages ."
37740002