IndraLab

Statements

USP7 deubiquitinates CHEK1. 7 / 7
2 | 5
reach
"Mechanistically, LINC02582 interacts with deubiquitinating enzyme ubiquitin specific peptidase 7 (USP7) to deubiquitinate and stabilize checkpoint kinase 1 (CHK1), a critical effector kinase in DNA damage response, thus promoting radioresistance."
31601781
ubibrowser
"Mechanistically, LINC02582 interacts with deubiquitinating enzyme ubiquitin specific peptidase 7 (USP7) to deubiquitinate and stabilize checkpoint kinase 1 (CHK1), a critical effector kinase in DNA damage response, thus promoting radioresistance."
31601781
reach
"LncRNA LINC02582 could promote breast cancer radioresistance by interacting with deubiquitinating enzyme ubiquitin specific peptidase 7 (USP7) to deubiquitinate and stabilize checkpoint kinase 1 (CHK1), a key molecule in DDR ."
36323697
ubibrowser
"Review"
27775833
reach
"USP7 purified from 293T cells transfected with USP7 alone decreased CHK1 poly-ubiquitination by 25% in vitro, and USP7 and ZEB1 co-purified from 293T cells with co-transfection of USP7 and ZEB1 reduced CHK1 poly-ubiquitination by 43% (XREF_FIG)."
25086746
reach
"Here we identified ZEB1 as an ATM substrate and the mechanism underlying the association between EMT and radioresistance (XREF_FIG) : in response to IR, ATM kinase is activated, which phosphorylates and stabilizes ZEB1; ZEB1 in turn interacts with and promotes the activity of USP7, which deubiquitinates and stabilizes CHK1."
25086746
reach
"68 HAUSP deubiquitinates checkpoint kinase Chk1, 69 its activator Claspin, 70 and checkpoint with forkhead and RING finger domain protein (Chfr)."
29967688