IndraLab

Statements

USP7 deubiquitinates CHEK1. 7 / 8
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reach
"USP7 purified from 293T cells transfected with USP7 alone decreased CHK1 poly-ubiquitination by 25% in vitro, and USP7 and ZEB1 co-purified from 293T cells with co-transfection of USP7 and ZEB1 reduced CHK1 poly-ubiquitination by 43% (XREF_FIG)."
25086746
reach
"Here we identified ZEB1 as an ATM substrate and the mechanism underlying the association between EMT and radioresistance (XREF_FIG) : in response to IR, ATM kinase is activated, which phosphorylates and stabilizes ZEB1; ZEB1 in turn interacts with and promotes the activity of USP7, which deubiquitinates and stabilizes CHK1."
25086746
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"In BC cells, USP7 collaborates with LINC02582 to deubiquitinate and stabilize CHK1, targeting miR-200c and enhancing radioresistance [238]."
38702734
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"68 HAUSP deubiquitinates checkpoint kinase Chk1, 69 its activator Claspin, 70 and checkpoint with forkhead and RING finger domain protein (Chfr)."
29967688
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"USP7 was shown to deubiquitinate key players in the ATR-Chk1 pathway, including Chk1 and its activator Claspin ( Alonso-de Vega et al., 2014 ; Faustrup et al., 2009 )."
32603670
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"LncRNA LINC02582 could promote breast cancer radioresistance by interacting with deubiquitinating enzyme ubiquitin specific peptidase 7 (USP7) to deubiquitinate and stabilize checkpoint kinase 1 (CHK1), a key molecule in DDR ."
36323697
reach
"The transcription factor ZEB1, which is activated during EMT, can directly interact with the deubiquitinase ubiquitin-specific protease 7 (USP7) to deubiquitinate CHK1 and initiate DNA damage repair [74]."
39090604