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USP7 deubiquitinates MDM4. 17 / 19
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"We next questioned the mechanism by which the deubiquitination of Hdmx/Hdm2 by HAUSP could be impaired."
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"HAUSP interacts with and deubiquitinates Hdmx, thereby counteracting the Hdm2-mediated ubiquitination and degradation of Hdmx."
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"However, under stressful conditions (such as DNA damage), increased levels of USP7 are unable to prevent ubiquitin-mediated degradation of Hdm2 and HdmX, indicating that USP7 is unable to deubiquitina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"MdmX phosphorylation (A38) inhibits (A40) the deubiquitination (A39) of MdmX by Hausp, which in turn increases ubiquitinated MdmX showing coherent regulation by DNA damage induced kinases."
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"Additionally, Wip1 inhibits p53 through MdmX and enhances the interaction of MdmX with ubiquitin specific peptidase 7 (USP7), which deubiquitinates and stabilizes MdmX."
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"More recent data suggest that Hausp also deubiquitinates Mdm4, another inhibitor of p53 activity."
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"HAUSP can also deubiquitinate and stabilize MdmX and has a role in DNA damaged induced degradation of MdmX [XREF_BIBR]."
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"Subsequently, HAUSP was shown to deubiquitinate Mdm2 and Mdmx, thereby stabilizing these proteins."
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"To determine whether HAUSP can also deubiquitinate Hdmx in vivo, U2OS cells were transfected with different combinations of HA-Hdmx, Hdm2, and HAUSP expression vectors."
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"Additionally, Mdm2, MdmX and p53 can be deubiquitinated by the HAUSP (herpesvirus associated ubiquitin specific protease) protein."
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"Importantly, HAUSP can deubiquitinate MDM2, MDMX, and p53."
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"To investigate whether Hdmx can be directly deubiquitinated by HAUSP, we used an in vitro system in which deubiquitination of p53 by HAUSP was shown ( Canning et al., 2004 )."
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"Because this result does not prove that HAUSP actively deubiquitinates Hdmx, the experiment was also performed post-Hdmx conjugation, i.e., by adding HAUSP after the ubiquitination reaction."
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"These data demonstrate that HAUSP is capable of deubiquitinating Hdmx in vitro."
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"In a variety of cancer research, USP7 can promote the deubiquitination of MDM2 and MDMX, inhibit p53 signaling, and inhibit cell cycle arrest and apoptosis, making USP7 a key target gene for cancer re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results demonstrate that HAUSP can specifically deubiquitinate Hdmx both in vitro and in vivo and provide a potential mechanism for the stabilization effect of HAUSP upon Hdmx.Previous studies h[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Importantly, upon DNA damage, HAUSP is less efficient in the deubiquitination of Hdmx and Hdm2 ( Figure 6 A, compare lanes 5 and 6)."
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