IndraLab

Statements

USP7 deubiquitinates MDM4. 10 / 10
1 1 | 1 7
ubibrowser
"Review"
27775833
reach
"USP7 preferentially deubiquitylates the E3 ligase HDM2 and its binding partner HDMX, resulting in the destabilisation of p53 and the repression of p53 transactivation activity (Refs 43, 44, 45)."
22088887
reach
"More recent data suggest that Hausp also deubiquitinates Mdm4, another inhibitor of p53 activity."
24488925
reach
"Additionally, Mdm2, MdmX and p53 can be deubiquitinated by the HAUSP (herpesvirus associated ubiquitin specific protease) protein."
28690977
reach
"Importantly, HAUSP can deubiquitinate MDM2, MDMX, and p53."
25808808
reach
"MdmX phosphorylation (A38) inhibits (A40) the deubiquitination (A39) of MdmX by Hausp, which in turn increases ubiquitinated MdmX showing coherent regulation by DNA damage induced kinases."
20174603
reach
"HAUSP can also deubiquitinate and stabilize MdmX and has a role in DNA damaged induced degradation of MdmX [XREF_BIBR]."
21624367
trips
"Subsequently, HAUSP was shown to deubiquitinate Mdm2 and Mdmx, thereby stabilizing these proteins."
16082221
reach
"Additionally, Wip1 inhibits p53 through MdmX and enhances the interaction of MdmX with ubiquitin specific peptidase 7 (USP7), which deubiquitinates and stabilizes MdmX."
22201816
signor
"Subsequently, hausp was shown to deubiquitinate mdm2 and mdmx, thereby stabilizing these proteins."
16082221