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USP7 deubiquitinates FOXP3. 14 / 14
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"Similarly, inhibition of proinflammatory stimuli likely decreases FOXP3 ubiquitination by HIF1α/pVHL E3 (Von Hippel-Lindau tumor suppressor protein E3 complex) or HSP70/STUB1 and increase FOXP3 deubiq[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Aberrant expression of USP7 decreases Foxp3 polyubiquitination, allowing Treg cell-mediated proliferation and tumor growth."
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"Ectopic expression of USP7 decreases the polyubiquitination of Foxp3 and increases the expression level of Foxp3 protein."
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"On the contrary, USP7 knockdown in Treg cells promotes Foxp3 polyubiquitination, decreases Foxp3 protein expression, and abrogates Treg-cell-mediated suppressive function in vitro."
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"Treatment of cells with USP7 inhibitor results in reduced Foxp3 levels while ectopic expression of USP7 decreases Foxp3 ubiquitination and correlates with an increase of Foxp3 expression (114, 115)."
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"Ectopic USP7 expression reduces FOXP3 polyubiquitination and increases protein levels."
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"56 In other words, USP7 deubiquitinates Foxp3, increasing Foxp3 protein levels and subsequently up-regulating Treg cells.A knockdown of USP7 expression in the Treg cells leads to a decrease in the Foxp3 protein levels reducing the suppression of the Treg-cell in vitro and vivo.45 USP7 inhibitors can affect the tumour growth limitation in immunocompetent mice and may have a key role in future cancer immunotherapies.56USP7 has also been implicated in regulation of the inflammasome."
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"To be exact, USP7 and USP21 could deubiquitinate and stabilize FOXP3, thereby positively regulating Treg cell function and immune tolerance."
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"In addition, both USP44 and USP7 expression reduce the ubiquitination of Foxp3, and there is a synergistic effect between these two deubiquitinating enzymes (DUBs) [38]."
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"On the contrary, USP7 expression decreased polyubiquitination of Foxp3 and enhanced Foxp3 expression (30)."
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"Ectopic expression of USP7 decreased FOXP3 polyubiquitination and increased FOXP3 expression."
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"In response to inflammatory cytokines such as interleukin-6 (IL-6), enhanced proteasomal degradation results from increased poly-ubiquitination by STUB1, as well as decreased ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of Foxp3 protein (Chen et al., 2013, van Loosdregt et al., 2013a)."
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"USP7 is upregulated in Treg cells, and the ectopic expression of USP7 decreases Foxp3 polyubiquitylation and increases Foxp3 expression."
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"USP7 deubiquitinates and stabilizes histone acetyltransferase tat-Interactive protein (Tip60) and transcriptional regulator Foxp3, which are essential for the survival of Treg cells [49]."
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