IndraLab

Statements

USP7 deubiquitinates FOXP3. 3 / 3
| 3
reach
"Treatment of cells with USP7 inhibitor results in reduced Foxp3 levels while ectopic expression of USP7 decreases Foxp3 ubiquitination and correlates with an increase of Foxp3 expression (114, 115)."
32117202
reach
"56 In other words, USP7 deubiquitinates Foxp3, increasing Foxp3 protein levels and subsequently up-regulating Treg cells.A knockdown of USP7 expression in the Treg cells leads to a decrease in the Foxp3 protein levels reducing the suppression of the Treg-cell in vitro and vivo.45 USP7 inhibitors can affect the tumour growth limitation in immunocompetent mice and may have a key role in future cancer immunotherapies.56USP7 has also been implicated in regulation of the inflammasome."
35005106
reach
"USP7 is upregulated in Treg cells, and the ectopic expression of USP7 decreases Foxp3 polyubiquitylation and increases Foxp3 expression."
31681337