IndraLab

Statements

USP7 deubiquitinates DNMT1. 13 / 14
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"USP7 inhibition increases ubiquitylation of DNMT1, and its degradation by the proteasome."
27118403
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"Consistent with previous studies that USP7 deubiquitinates and stabilizes DNMT1, knockdown of USP7 in several cell lines (HEK293T, HeLa, HCT116 p53-/- and p53 +/+ cells) resulted in a significant decrease in the DNMT1 protein level, but not in the DNMT1 messenger RNA level (XREF_FIG and XREF_SUPPLEMENTARY)."
25960197
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"In a pivotal counterbalance, USP7 mediates the deubiquitination of both UHRF1 and DNMT1, rescuing them from proteasomal degradation, thus ensuring their stability and function within the cell [44]."
39051184
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"The UHRF1 and DNMT1 complex has been reported to contain USP7 that deubiquitinates and stabilizes DNMT1 XREF_BIBR, XREF_BIBR."
26065575
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"Both UHRF1 and DNMT1 are deubiquitinated and stabilized by USP7 [XREF_BIBR, XREF_BIBR], while UHRF1 is the negative regulator of DNMT1 [XREF_BIBR]."
26046769
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"We recently showed that USP7 deubiquitinates DNMT1 and functions in concert with several other proteins to regulate DNMT1 stability."
23106643
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"HAUSP deubiquitinates DNMT1 and protects it from proteasomal degradation."
21045206
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"USP7 deubiquitinates DNA methyltransferase (DNMT1), resulting in increased stability of DNMT1."
40225869
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"FA decreased the ubiquitination of DNMT1 (p = 0.0753), DNMT3A (p = 0.0008), and DNMT3B (p < 0.0001) by decreasing UHRF1 (p < 0.0001) and USP7 (p < 0.0001)."
31060424
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"In addition, USP7 deubiquitinates many other proteins, including DNMT1 [ 15 ], N-Myc [ 16 ] and Tip60 [ 17 , 18 ], among others."
32497973
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"In the hypermethylated region of the DMRs, we observed that a deubiquitinating enzyme, USP7, is enriched with methylation information and it has been shown that USP7 can regulate overall DNA methylation by deubiquitinating DNA methyltransferase-1 and Uhrf1 (58, 59)."
38097189
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"Recent evidence has indicated that USP7 also deubiquitinates DNMT1 during S-phase; in late S-phase, acetylation of DNMT1 by Tip60 leads to disruption of the DNMT1 and USP7 complex."
26299963
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"Conversely, HDAC1 (histone deacetylase 1) induced DNMT1 deacetylation and HAUSP (herpes virus associated ubiquitin specific protease) modulated DNMT1 deubiquitination to stabilize DNMT1 44."
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