The INDRA Database

reach

"The UHRF1 and DNMT1 complex has been reported to contain USP7 that deubiquitinates and stabilizes DNMT1 XREF_BIBR, XREF_BIBR."

26065575

➶

reach

"Recent evidence has indicated that USP7 also deubiquitinates DNMT1 during S-phase; in late S-phase, acetylation of DNMT1 by Tip60 leads to disruption of the DNMT1 and USP7 complex."

26299963

➶

reach

"Importantly, both HDAC3 and USP7 decreased DNMT1 ubiquitination (XREF_FIG, DNMT1 IP)."

28490812

➶

reach

"Consistent with previous studies that USP7 deubiquitinates and stabilizes DNMT1, knockdown of USP7 in several cell lines (HEK293T, HeLa, HCT116 p53-/- and p53 +/+ cells) resulted in a significant decrease in the DNMT1 protein level, but not in the DNMT1 messenger RNA level (XREF_FIG and XREF_SUPPLEMENTARY)."

25960197

➶

reach

"Conversely, HDAC1 (histone deacetylase 1) induced DNMT1 deacetylation and HAUSP (herpes virus associated ubiquitin specific protease) modulated DNMT1 deubiquitination to stabilize DNMT1 44."

29367628

➶

reach

"We recently showed that USP7 deubiquitinates DNMT1 and functions in concert with several other proteins to regulate DNMT1 stability."

23106643

➶

reach

"Together, these observations suggest that multistep posttranslational modification events may be required to dissociate the UHRF1 and USP7 complex during M phase.Recent evidence has indicated that USP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

26299963

➶

reach

"FA decreased the ubiquitination of DNMT1 (p = 0.0753), DNMT3A (p = 0.0008) and DNMT3B (p < 0.0001) by decreasing UHRF1 (p < 0.0001) and USP7 (p < 0.0001)."

31060424

➶

reach

"HAUSP deubiquitinates DNMT1 and protects it from proteasomal degradation."

21045206

➶

ubibrowser

"Review"

27775833

➶

reach

"USP7 inhibition increases ubiquitylation of DNMT1, and its degradation by the proteasome."