IndraLab

Statements

USP7 deubiquitinates ERCC6. 9 / 9
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"While both CSB and UV stimulated scaffold protein A (UVSSA) exhibit a biphasic decrease and recovery upon UV irradiation, only CSB recovery depends on USP7, which physically interacts with and deubiquitinates CSB."
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"Review"
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"Upon transcription arrest, these factors bind strongly to RNAPII, and USP7 deubiquitinates CSB to stabilize it."
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"Upon transcription arrest, these factors bind strongly to RNAPII, and USP7 deubiquitylates CSB to stabilize it."
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"Additional factors continue to be identified : Examples include NEDD4, that is implicated in DNA damage induced ubiquitination of the RNA polymerase II subunit RPB1 to mark it for proteosomal degradation; UVSSA and USP7 that bind to RNAPII upon transcription arrest and deubiquitinate CSB to prevent its degradation; and the SPT16 FACT chromatin remodeler."
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"Upon transcription arrest, these factors bind strongly to RNAPII, and USP7 deubiquitylates CSB to stabilize it."
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"To avoid premature degradation of CSB, UVSSA, which binds firmly to stalled RNA pol II, recruits USP7, an enzyme that promotes deubiquitination of CSB, highlighted in blue in XREF_FIG."
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"Here, we demonstrate that USP7 deubiquitinates CSB to maintain its levels after ultraviolet (UV)-induced DNA damage."
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"Additional factors continue to be identified : Examples include NEDD4, that is implicated in DNA damage induced ubiquitination of the RNA polymerase II subunit RPB1 to mark it for proteosomal degradat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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