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USP7 deubiquitinates FOXP3. 10 / 10
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"On the other hand, the deubiquitinase USP7 is able to deubiquitinate FOXP3 in an HSP90 dependent manner and stabilizes FOXP3 to increase Treg number to enhance Treg suppressive activity."

"Furthermore, cambogin (10 μM) prevented Foxp3 loss in human primary Treg cells in vitro, and promoted USP7-mediated Foxp3 deubiquitination and increased Foxp3 protein expression in LPS-treated cells."

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"E3 ubiquitin ligase Stub1 induces the K48 polyubiquitination and degradation of Foxp3, whereas deubiquitinase USP7 decreases Foxp3 polyubiquitination and increases Foxp3 expression XREF_BIBR."

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"USP7 mRNA expression was significantly upregulated in iTreg cells but not in other Th subsets, further supporting a role for the USP7 deubiquitination of Foxp3 in Treg cell differentiation (XREF_FIG)."

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"USP7 Associates with and Deubiquitinates Foxp3."

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"To determine whether USP7 could also deubiquitinate Foxp3, we analyzed Foxp3 polyubiquitination in transfected HEK 293T cells."

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"In a previous study, van Loosdregt et al. (2013) showed that USP7 interacted with and deubiquitinated Foxp3, thereby increasing Foxp3 protein levels."

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"Conversely, the DUB Usp7 deubiquitinates and stabilizes Foxp3 to promote Treg functions."

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"In addition, utilizing the UbiTest analysis we demonstrate that inhibition of USP7 increases polyubiquitination of Foxp3, Tip60 and USP7."

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"Foxp3 polyubiquitination was reduced with ectopic expression of USP7, indicating that USP7 can directly deubiquitinate Foxp3 (XREF_FIG)."