IndraLab

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USP7 deubiquitinates FOXP3. 10 / 10
1 | 9
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"In addition, utilizing the UbiTest analysis we demonstrate that inhibition of USP7 increases polyubiquitination of Foxp3, Tip60 and USP7."
29236775
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"USP7 Associates with and Deubiquitinates Foxp3."
23973222
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"E3 ubiquitin ligase Stub1 induces the K48 polyubiquitination and degradation of Foxp3, whereas deubiquitinase USP7 decreases Foxp3 polyubiquitination and increases Foxp3 expression XREF_BIBR."
25695215
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"USP7 mRNA expression was significantly upregulated in iTreg cells but not in other Th subsets, further supporting a role for the USP7 deubiquitination of Foxp3 in Treg cell differentiation (XREF_FIG)."
23973222
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"To determine whether USP7 could also deubiquitinate Foxp3, we analyzed Foxp3 polyubiquitination in transfected HEK 293T cells."
23973222
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"Foxp3 polyubiquitination was reduced with ectopic expression of USP7, indicating that USP7 can directly deubiquitinate Foxp3 (XREF_FIG)."
23973222
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"In a previous study, van Loosdregt et al. (2013) showed that USP7 interacted with and deubiquitinated Foxp3, thereby increasing Foxp3 protein levels."
29352742
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"On the other hand, the deubiquitinase USP7 is able to deubiquitinate FOXP3 in an HSP90 dependent manner and stabilizes FOXP3 to increase Treg number to enhance Treg suppressive activity."
26441996
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"Conversely, the DUB Usp7 deubiquitinates and stabilizes Foxp3 to promote Treg functions."
27012466
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"Furthermore, cambogin (10 muM) prevented <span class="match term1">Foxp3</span> loss in human primary Treg cells in vitro, and promoted <span class="match term0">USP7</span>-mediated <span class="match term1">Foxp3</span> deubiquitination and increased <span class="match term1">Foxp3</span> protein expression in LPS-treated cells."
29352742