IndraLab

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USP7 deubiquitinates RAD18. 4 / 4
1 | 3
reach
"USP7 deubiquitinates RAD18 which leads to stabilisation and up-regulation of PCNA ubiquitination."
35005106
ubibrowser
"?Here, we identify the de-ubiquitylating enzyme USP7 as a critical regulator of Rad18 protein levels. Loss of USP7 destabilizes Rad18 and compromises UV-induced PCNA mono-ubiquitylation and Pol 畏 recruitment to stalled replication forks.?"
25961918
reach
"In response to replication stress, USP7 also deubiquitylates and stabilizes both Rad18 (so that it can monoubiquitylate PCNA) and the TLS polymerase, polymerase eta (POL-eta), and this facilitates the bypass of lesions through the error-prone TLS pathway."
29357069
reach
"This is likely concomitant with Pol eta deubiquitination by USP7 and PIAS1 and Rad18 dependent SUMOylation [XREF_BIBR, XREF_BIBR] (XREF_FIG A)."
28067843