IndraLab

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USP7 deubiquitinates RAD18. 6 / 6
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"In response to replication stress, USP7 also deubiquitylates and stabilizes both Rad18 (so that it can monoubiquitylate PCNA) and the TLS polymerase, polymerase eta (POL-eta), and this facilitates the bypass of lesions through the error-prone TLS pathway."
29357069
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"USP7 plays important roles in genomic stability and DNA damage response by deubiquitinating RNF168, BRCA1, 53BP1, Rad18, and many others [ 10–13 ]."
31866294
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"We demonstrate that <span class="match term0">USP7</span> associates with <span class="match term1">Rad18</span> directly via a consensus <span class="match term0">USP7</span>-binding motif and can disassemble <span class="match term1">Rad18</span>-dependent poly-ubiquitin chains both in vitro and in vivo"
25961918
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"USP7 can deubiquitinate both PCNA [78] and RAD18 [76] , the E3 Ub ligase responsible for this ubiquitination [79] ."
28591556
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"This is likely concomitant with Pol eta deubiquitination by USP7 and PIAS1 and Rad18 dependent SUMOylation [XREF_BIBR, XREF_BIBR] (XREF_FIG A)."
28067843
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"USP7 deubiquitinates RAD18 which leads to stabilisation and up-regulation of PCNA ubiquitination."
35005106