IndraLab

Statements

USP7 deubiquitinates NFE2L1. 4 / 4
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"In contrast, knockdown or pharmacologic inhibition of USP7 dramatically increased ubiquitination of TCF11 and Nrf1a and reduction of their steady state levels."
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"USP7 promotes deubiquitination of TCF11 and Nrf1a."
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"To verify that USP7 deubiquitinates TCF11 and Nrf1a specifically, HEK293 cells were transfected with TCF11-V5 or Nrf1a-V5 and HA-tagged ubiquitin along with increasing amounts of Flag-tagged USP7, or USP7-CS, a dominant negative catalytically inactive form of USP7."
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reach
"These results show that USP7 is able to stimulate deubiquitination of TCF11 and Nrf1a in cells and support the idea that USP7 regulates the stability of Nrf1 proteins through USP7 deubiquitinase activity."
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