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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP7 deubiquitinates BCR-ABL. 4 / 4

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"Because the previous study showed that USP7 binds to and deubiquitinates BCR-ABL, we wondered to know whether ART disrupts this interaction."

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"Given that USP7 is a Dub and it stabilizes BCR-ABL, we next wondered whether USP7 could deubiquitinate BCR-ABL."

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"USP7 interacts with and deubiquitinates BCR-ABL."

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"As showed in Fig. 8D, ectopic expression of USP7 significantly reduced BCR-ABL polyubiquitination but it was markedly recovered by ART, suggesting ART acts against USP7."

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USP7 deubiquitinates BCR-ABL. 4 / 4

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