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USP7 deubiquitinates UVSSA. 1 / 2

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"In contrast to Pol II and UVSSA, CSB is deubiquitinated by USP7 to reverse its ubiquitination state in TC-NER.The physiological significancxe of Pol II degradation may rely on two aspects: for one aspect, the ubiquitination and degradation of RPB1 activate TC-NER and, in parallel, prevents prolonged transcription arrest after sending the TC-NER initiation signal (Nakazawa et al., 2020)."

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USP7 deubiquitinates UVSSA. 1 / 2

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