IndraLab

Statements

USP7 deubiquitinates RB1. 4 / 5
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reach
"The activity of HAUSP on pRb was subject to MDM2 in a context-specific fashion, where HAUSP deubiquitinated and stabilized pRb with low level of MDM2 in normal cells while high level of MDM2 hampered HAUSP activity on pRb leading to pRb degradation in cancer cells [57]."
35650644
reach
"HAUSP deubiquitinates Rb in vivo and in vitro, leading to an increased cell population in the G1 phase."
24823443
reach
"In addition to stabilization of MDM2 by HAUSP, it might be possible that HAUSP reverses Rb ubiquitination by MDM2 in normal cells but is overwhelmed by abundant MDM2 in the case of tumor tissues or cancer cells."
24823443
reach
"HAUSP deubiquitinates Rb."
24823443