IndraLab

Statements

USP7 deubiquitinates NOX4. 4 / 4
| 4
reach
"This study showed that USP7 interacted with and deubiquitinated NOX4, and the inhibition of ROS production or administration of NOX4 inhibitor significantly inhibited oeUSP7 induced pro OA effects such as enhanced pyroptosis, elevated ROS level, increased IL-1beta and IL-18 levels, and overexpression of NLRP3, GSDMD-N, active caspase-1, and pro-caspase-1."
33584299
reach
"USP7 inhibited NOX4 ubiquitination for degradation which leads to elevated ROS production."
33584299
reach
"In summary, this study showed that USP7 deubiquitinates NOX4 to stabilize it, which leads to elevated ROS production."
33584299
reach
"Our findings on the regulatory role of NOX4 on inflammasome formation/activation reinforce a recent study in an OA rat model by Liu G et., which demonstrated that deubiquitylation of NOX4 by USP7 led [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36087742