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USP7 deubiquitinates HIF1A. 10 / 10
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"K63 polyubiquitinated HAUSP deubiquitinates HIF-1alpha and dictates H3K56 acetylation promoting hypoxia induced tumour progression."
27934968
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"The accumulative USP7 resulted in deubiquitylation and stabilization of HIF-1alpha, thereby facilitating resistance to oxaliplatin."
34740372
ubibrowser
"K63-polyubiquitinated <span class="match term0">HAUSP</span> deubiquitinates <span class="match term1">HIF-1A</span> and dictates H3K56 acetylation promoting hypoxia-induced tumour progression"
27934968
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"Beyond, USP7 deubiquitinates and stabilizes HIF1alpha, PHF8 could regulate HIF1alpha through USP7 [XREF_BIBR]."
28734980
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"USP7, also known as HAUSP (herpesvirus associated ubiquitin specific protease), deubiquitinates HIF-1alpha and stabilizes it."
33466790
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"Simultaneously, the deubiquitylation of HIF-1a induced by USP7 was significantly enhanced by treatment with PARGi in QBC939 cells under hypoxic conditions (Fig. 6E, Supplementary 5G)."
37821935
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"HAUSP interacts with and deubiquitinates HIF-1alpha."
27934968
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"Since both HAUSP and HIF-1alpha play a significant role in tumour progression and aggressiveness XREF_BIBR XREF_BIBR, we evaluated whether HAUSP could deubiquitinate HIF-1alpha through interacting with HIF-1alpha."
27934968
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"These results demonstrate that HAUSP decreases HIF-1alpha ubiquitination through recognizing a consensus sequence located in HIF-1alpha."
27934968
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"Given these findings, it can be hypothesized that USP7 is recruited by persistent PARylation to reverse the ubiquitylation of HIF-1a."
37821935