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USP7 deubiquitinates CTNNB1. 12 / 12
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"Conversely, USP7 promotes deubiquitination of beta-catenin with RNF220, which is a RING domain E3 ligase, and upregulates the Wnt signaling pathway [XREF_BIBR]."
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"USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination"
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"Ubiquitin specific peptidase 7 (USP7) mediates deubiquitination of beta-catenin and enhances canonical Wnt signaling [XREF_BIBR]."
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"Together, our data imply that USP7 interacts with the N terminus of beta-catenin directly to mediate beta-catenin deubiquitination when APC is mutated."
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"USP7 Interacts with the N Terminus of beta-Catenin Directly to Mediate beta-Catenin Deubiquitination."
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"It was reported that USP7 could activate Wnt signaling pathway and promote tumorigenesis by mediating β-catenin deubiquitination in adenomatous polyposis coli (APC) mutations from colon tumors [38]."
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"Indeed, CRISPR targeting of USP7 in the CID deleted APC4 cells readily restored beta-catenin ubiquitination in the destruction complex (XREF_FIG D and XREF_SUPPLEMENTARY I)."
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"Moreover, ZMIZ2 recruits the enzyme USP7, which deubiquitylates and stabilizes beta-catenin, thereby facilitating colorectal tumorigenesis."
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"Specifically, USP7 binds the N-terminus of β-catenin when the APC losses CID confirming the essential role of USP7 in the activation of Wnt signalling and cell survival in colorectal cancers.13 Ma et al showed that the USP7/RNF220 complex activates the Wnt pathway while knockdown of USP7 using a small interfering RNA (siRNA) strategy, reduces the expression of Wnt.18 Conversely, a recent study proposed that USP7 deubiquitinates β-catenin and RNF220 independently and works as a tumour-specific condition when APC is mutated."
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"USP7 Depletion in APC Truncated CRC Cells Suppresses Aberrant Wnt Activation by Restoring beta-Catenin Ubiquitination."
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"In addition, it has been reported that USP7 promotes deubiquitination of β-catenin through directly binding to a region in proximity to the phospho-degron of β-catenin ."
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"The RNF220 and USP7 complex deubiquitinates beta-catenin and enhances canonical Wnt signaling."
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