IndraLab

Statements

USP7 deubiquitinates CTNNB1. 19 / 20
1 | 19
reach
"USP7 Depletion in APC Truncated CRC Cells Suppresses Aberrant Wnt Activation by Restoring beta-Catenin Ubiquitination."
29045831
reach
"Indeed, CRISPR targeting of USP7 in the CID deleted APC4 cells readily restored beta-catenin ubiquitination in the destruction complex (XREF_FIG D and XREF_SUPPLEMENTARY I)."
29045831
reach
"Conversely, USP7 promotes deubiquitination of beta-catenin with RNF220, which is a RING domain E3 ligase, and upregulates the Wnt signaling pathway [XREF_BIBR]."
32486158
reach
"Both ubiquitin-specific peptidase 7 (USP7) and COP9 signalosome subunit 5 (CSN5) mediate the deubiquitination and stabilization of β-catenin, thus promoting PDAC proliferation (Li et al., 2020a; Ma et al., 2021)."
38174069
reach
"It was reported that USP7 could activate Wnt signaling pathway and promote tumorigenesis by mediating β-catenin deubiquitination in adenomatous polyposis coli (APC) mutations from colon tumors [38]."
34740372
reach
"The RNF220 and USP7 complex deubiquitinates beta-catenin and enhances canonical Wnt signaling."
25266658
reach
"However, a recent study suggested that USP7 physically deubiquitinated Axin, but not β-catenin, thus serving as a negative regulator of Wnt signaling [ 37 ]."
32278038
reach
"Specifically, USP7 binds the N-terminus of β-catenin when the APC losses CID confirming the essential role of USP7 in the activation of Wnt signalling and cell survival in colorectal cancers.13 Ma et al showed that the USP7/RNF220 complex activates the Wnt pathway while knockdown of USP7 using a small interfering RNA (siRNA) strategy, reduces the expression of Wnt.18 Conversely, a recent study proposed that USP7 deubiquitinates β-catenin and RNF220 independently and works as a tumour-specific condition when APC is mutated."
35005106
reach
"ZMIZ2 recruits the enzyme USP7, which deubiquitylates and stabilizes β-catenin, thereby facilitating colorectal tumorigenesis [19]."
38254216
reach
"In addition, it has been reported that USP7 promotes deubiquitination of β-catenin through directly binding to a region in proximity to the phospho-degron of β-catenin ."
31519875
reach
"In addition, USP7 deubiquitinates β-catenin and activate Wnt signaling to promote colon cancer development [51]."
37081042
reach
"Ubiquitin specific peptidase 7 (USP7) mediates deubiquitination of beta-catenin and enhances canonical Wnt signaling [XREF_BIBR]."
28430641
reach
"Taken together, our data suggest that inhibition of USP7 by P5091 induces polyubiquitination of β-catenin and accelerates β-catenin degradation.Then we tested the effect of P5091 on β-catenin expressi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28216017
reach
"Our recent study reported that USP7 deubiquitinated and stabilized β-catenin through bridge of RNF220, leading to amplification of Wnt signaling [20] ."
28216017
reach
"USP7 promotes tumour proliferation by deubiquitinating β-catenin protein to activate the Wnt signalling pathway in colorectal cancers (CRCs) associated with mutations in the APC gene [ 38 ]."
37625777
reach
"Moreover, ZMIZ2 recruits the enzyme USP7, which deubiquitylates and stabilizes beta-catenin, thereby facilitating colorectal tumorigenesis."
31527801
reach
"Further, USP7 depletion restored β-catenin ubiquitination to suppress Wnt signalling in adenomatous polyposis coli-mutated colorectal cancer [ 10 ]."
33127578
reach
"USP7 Interacts with the N Terminus of beta-Catenin Directly to Mediate beta-Catenin Deubiquitination."
29045831
reach
"Together, our data imply that USP7 interacts with the N terminus of beta-catenin directly to mediate beta-catenin deubiquitination when APC is mutated."
29045831