IndraLab

Statements

USP7 deubiquitinates FOXO4. 7 / 8
1 | 7
reach
"For example, MDM2 interacts USP7 to maintain the protein stability [57], and USP7 deubiquitinates FOXO4, leading to its nuclear localization and attenuation of transcriptional activity [58]."
38725075
reach
"USP7 modulates this activity by deubiquitinating FOXO4, causing nuclear export (232)."
34391779
reach
"On the other hand, the deubiquitinating enzyme ubiquitin-specific protease (USP7) deubiquitinates FOXO4, thereby inhibiting FOXO activity through nuclear exclusion (van der Horst et al. 2006)."
38466341
reach
"USP7 negatively regulates FOXO by antagonizing FOXO4 monoubiquitylation and activity without affecting protein stability."
26154057
reach
"The deubiquitination of Foxo4 by Usp7/Hausp thus ensures the transient nature of a stress-induced cell cycle arrest [ 54 ]."
18346885
reach
"When the cellular conditions have improved and the cell cycle machinery needs to resume, Foxo4 is deubiquitinated by the already described Usp7/Hausp."
18346885
reach
"USP7 deubiquitinates Foxo4 protein under normal conditions, ensuring transient arrest of the cell cycle [249,250]."
34814083