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USP7 deubiquitinates MYCN. 9 / 10
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"HAUSP (USP7), a deubiquitinase, is implicated in the deubiquitination of MYCN protein, thereby thwarting its proteasomal degradation (30, 31)."
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"HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma."
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"The ubiquitin specific peptidase HAUSP (also known as USP7) binds to and deubiquitinates MYCN leading to its stabilization (XREF_FIG)."
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"In addition, USP7 deubiquitinates many other proteins, including DNMT1 [ 15 ], N-Myc [ 16 ] and Tip60 [ 17 , 18 ], among others."
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"HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma."
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"HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma."
32003251
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"Furthermore, depleting N-MYC expression through the pharmacological inhibition of the deubiquitinase USP7, that directly deubiquitinates N-MYC and decreases protein stability, restored platinum sensitivity in MYCN-overexpressing PDX models [13]."
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"First, DUB deregulation has been reported to contribute to the accumulation of key oncoproteins, such as ubiquitin specific protease 7 (USP7) deubiquitinates and stabilizes N-Myc in neuroblastoma25, and USP28 is required for MYC stability26."
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"For instance, USP7 deubiquitinates and stabilizes N-myc protein to promote neuroblastoma progression [50]."
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