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USP7 deubiquitinates NEK2. 5 / 5
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"USP7 interacts with and deubiquitinates NEK2."
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"Studies have shown that USP7 deubiquitinates NEK2 and affects its stability XREF_BIBR."
33754007
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"We therefore examined whether USP7 deubiquitinated NEK2 and affected its function in PAs, and confirmed a specific interaction between USP7 and NEK2 in transiently transfected HEK293T cells using co-immunoprecipitation."
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"Next we examined whether the increase in NEK2 protein levels was dependent upon the deubiquitinating enzymatic activity of USP7, and found that ectopic expression of USP7 decreased NEK2 ubiquitination."
33754007
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"Taken together, our data indicate that <span class="match term0">USP7</span> stabilizes <span class="match term1">NEK2</span> through deubiquitination of <span class="match term1">NEK2</span>, and inhibition of <span class="match term0">USP7</span> with P5091 depletes <span class="match term1">NEK2</span> protein"
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