IndraLab

Statements

USP7 deubiquitinates KAT5. 11 / 11
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"Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway."
29056421
ubibrowser
"USP7 deubiquitinates and stabilizes the acetyltransferase Tip60 to induce p53-dependent apoptotic pathways"
25121098
reach
"Rather, we found that ATF3 promoted USP7 mediated deubiquitination of Tip60 thereby diminishing Tip60 ubiquitination required for proteosomal degradation."
25865756
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"As ATF3 appears to bind to MDM2 as well as p53 XREF_BIBR, XREF_BIBR, the observation that ATF3 promoted USP7 mediated deubiquitination of Tip60 suggests a possibility that ATF3 might also regulate the MDM2 or p53 stability through regulating USP7 in the DNA damage response."
25865756
reach
"ATF3 promotes USP7 mediated deubiquitination of Tip60."
25865756
reach
"As ATF3 alone did not appear to decrease the Tip60 ubiquitination level (XREF_FIG, lane 3), these results argue for the notion that ATF3 promoted USP7 mediated deubiquitination of Tip60 thereby stabilizing the latter protein."
25865756
trips
"Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway."
23775119
reach
"In addition, utilizing the UbiTest analysis we demonstrate that inhibition of USP7 increases polyubiquitination of Foxp3, Tip60 and USP7."
29236775
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"Here we show that USP7 interacts with and deubiquitinates Tip60 both in vitro and in vivo."
23775119
reach
"USP7, a dominant deubiquitinating enzyme in 3T3-L1 adipocytes and mouse adipose tissue, deubiquitinates Tip60 both in intact cells and in vitro and increases Tip60 protein levels."
24141283
reach
"Deubiquitination of Tip60 by USP7 determines the activity of the p53 dependent apoptotic pathway."
23775119