IndraLab

Statements

USP7 deubiquitinates KAT5. 17 / 18
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"Rather, we found that ATF3 promoted USP7 mediated deubiquitination of Tip60 thereby diminishing Tip60 ubiquitination required for proteosomal degradation."
25865756
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"As ATF3 appears to bind to MDM2 as well as p53 XREF_BIBR, XREF_BIBR, the observation that ATF3 promoted USP7 mediated deubiquitination of Tip60 suggests a possibility that ATF3 might also regulate the MDM2 or p53 stability through regulating USP7 in the DNA damage response."
25865756
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"When Foxp3 is deubiquitinated, USP7 can also deubiquitinate and stabilize the histone/protein acetyltransferase Tip60, which is required for the acetylation, dimerization and function of Foxp3 [162, 163]."
36998063
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"Tip60 is turned over in cells by the ubiquitin–proteasome system and USP7 interacts with and deubiquitinates Tip60 both in vitro and in vivo."
25911240
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"In addition, USP7 deubiquitinates many other proteins, including DNMT1 [ 15 ], N-Myc [ 16 ] and Tip60 [ 17 , 18 ], among others."
32497973
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"Deubiquitination of Tip60 by USP7 determines the activity of the p53 dependent apoptotic pathway."
23775119
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"USP7, a dominant deubiquitinating enzyme in 3T3-L1 adipocytes and mouse adipose tissue, deubiquitinates Tip60 both in intact cells and in vitro and increases Tip60 protein levels."
24141283
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"A previous study showed that USP7 regulates the early differentiation of mouse 3T3-L1 preadipocytes by deubiquitinating the histone acetyltransferase TIP60 [21]."
35955807
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"In addition, USP7 plays an important role in 3T3-L1 cell differentiation and mouse adipose tissue by deubiquitinating the acetyltransferase Tip60, which constitutes a transcriptional co-regulatory complex that induces adipocyte differentiation."
38012162
trips
"Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway."
23775119
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"Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway."
29056421
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"ATF3 promotes USP7 mediated deubiquitination of Tip60."
25865756
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"As ATF3 alone did not appear to decrease the Tip60 ubiquitination level (XREF_FIG, lane 3), these results argue for the notion that ATF3 promoted USP7 mediated deubiquitination of Tip60 thereby stabilizing the latter protein."
25865756
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"It has been demonstrated that USP7 regulates early adipogenesis through deubiquitinating TIP60 [21] ."
27452504
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"Here we show that USP7 interacts with and deubiquitinates Tip60 both in vitro and in vivo."
23775119
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"USP7 deubiquitinates and stabilizes histone acetyltransferase tat-Interactive protein (Tip60) and transcriptional regulator Foxp3, which are essential for the survival of Treg cells [49]."
36428632
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"In addition, utilizing the UbiTest analysis we demonstrate that inhibition of USP7 increases polyubiquitination of Foxp3, Tip60 and USP7."
29236775