IndraLab

Statements

USP7 leads to the deubiquitination of AXIN1. 4 / 4
1 | 3
ubibrowser
"<span class="match term0">USP7</span> directly interacts with <span class="match term1">Axin</span> through its TRAF domain, and promotes deubiquitination and stabilization of <span class="match term1">Axin</span>"
31519875
reach
"Overexpression of wild-type USP7, but not the C233A mutant, decreased poly-ubiquitination of ectopically expressed Axin1 (Fig. 3g)."
31519875
reach
"Consistently, knockout of USP7 in YAPC cells enhanced poly-ubiquitination of endogenous AXIN1 in the TUBE assay (Fig. 3h)."
31519875
reach
"Ubiquitin carboxyl-terminal hydrolase 7 (USP7), a potent negative regulator of Wnt and beta-catenin signaling, promotes the deubiquitination and stabilization of AXIN by interacting with AXIN through its TRAF domain [XREF_BIBR]."
33291655