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USP7 leads to the deubiquitination of AXIN1. 4 / 4
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"Consistently, knockout of USP7 in YAPC cells enhanced poly-ubiquitination of endogenous AXIN1 in the TUBE assay (Fig. 3h)."
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"Ubiquitin carboxyl-terminal hydrolase 7 (USP7), a potent negative regulator of Wnt and beta-catenin signaling, promotes the deubiquitination and stabilization of AXIN by interacting with AXIN through its TRAF domain [XREF_BIBR]."
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"USP7 directly interacts with Axin through its TRAF domain, and promotes deubiquitination and stabilization of Axin."
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"Overexpression of wild-type USP7, but not the C233A mutant, decreased poly-ubiquitination of ectopically expressed Axin1 (Fig. 3g)."
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