IndraLab

Statements


USP7 leads to the deubiquitination of Cyclin on A2. 3 / 3
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"The exosomal circ-DB internalized by HCC cells can be used as a molecular sponge to absorb miR-34a endogenously, thereby deinhibiting the downstream target USP7, which inhibits the ubiquitination of cyclin A2 protein to maintain its stability."

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"USP7 mediates the deubiquitination of cyclin A2 in HCC."

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"Exosomal circ-DB absorbed miR-34a and enhanced the deubiquitination of cyclin A2 mediated by USP7, promoting HCC growth 21."