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USP7 deubiquitinates IKK_complex. 2 / 2
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"USP15 negatively regulates NFκB activation by deubiquitinating IκB (Harhaj and Dixit 2011), while USP7 decreases NFkB signalling by deubiquitinating TRAF6 and IKK (Nanduri et al. 2013)."
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"The ICP0 and USP7 interaction is responsible for the deubiquitination and deactivation of TRAF6 and IKKγ proteins in the cytoplasm which results in the diminishing of the innate immune response ( Daub[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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