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USP7 deubiquitinates CDC25A. 3 / 3

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"Furthermore, in a co-immunoprecipitation assay, we found that HAUSP interacts with and deubiquitinates Cdc25A both exogenously and endogenously."

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"These data support that BRE upregulation facilitates deubiquitylation of CDC25A in the presence of DNA damage by USP7."

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"USP7 also deubiquitinates the cell cycle checkpoint CDC25A upon DNA damage in the BRCA deficient cells and contributes to cell survival despite the loss of BRCA mediated genome integrity."

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USP7 deubiquitinates CDC25A. 3 / 3

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