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USP7 deubiquitinates TRAF6. 10 / 10
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"K48-polyUb in TRAF6 was deubiquitinated by HAUSP, and PE_PGRS38 inhibited the deubiquitination of K48-polyUb in TRAF6 but not of K63-polyUb in TRAF6 ( Figure 4A )."
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"This inhibition of host immunity was also reported following lysine-11-linked ubiquitination of Rv0222 by the host E3 ubiquitin ligase ANAPC2 involving SHP1 and TRAF6, or deubiquitination of TRAF6 by HAUSP after PE_PGRS38 ectopic expression in M. smegmatis in murine bone marrow-derived macrophages (Wang et al., 2020; Kim et al., 2022)."
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"The ICP0 and USP7 interaction is responsible for the deubiquitination and deactivation of TRAF6 and IKKγ proteins in the cytoplasm which results in the diminishing of the innate immune response ( Daub[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"HAUSP regulates the level or function of proteins via deubiquitination (22, 23) and was also reported to deubiquitinate K48-polyUb in TRAF6 and mediate cytokine production (31)."
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"Cytoplasmic USP7 binds to and deubiquitinates TRAF6 and IKKgamma, thus terminating TLR mediated NF-kappaB and JNK activation."
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"Subsequently, we analyzed the effect of USP7 on TRAF6 ubiquitination; the results suggested that USP7 mostly acted on the CC domain in order to deubiquitinate TRAF6 (Fig. 4H)."
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"In HSV-activated THP1 cells USP7 promotes de-ubiquitination of TRAF6 [43]."
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"Upon RANKL stimulation, USP7 de-ubiquitinates TRAF6 at the RING and CC domains, resulting in the suppression of the TAK-1, MAPKs, and canonical NF-κB signaling pathways."
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"While in vitro interactions of USP7 NTD with TRAFs 1 to 6, intracellular USP7 binding to TRAFs 4 and 6, and USP7 deubiquitination of TRAF6 have been reported, biological targeting and deubiquitination of the TRAFs by USP7 have generally not been assessed."
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"USP15 negatively regulates NFκB activation by deubiquitinating IκB (Harhaj and Dixit 2011), while USP7 decreases NFkB signalling by deubiquitinating TRAF6 and IKK (Nanduri et al. 2013)."
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