IndraLab

Statements

USP7 deubiquitinates TRAF6. 3 / 3
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"USP15 negatively regulates NFjB activation by deubiquitinating IjB (Harhaj and Dixit 2011) , while USP7 decreases NFkB signalling by deubiquitinating TRAF6 and IKK (Nanduri et al. 2013 )."
30244323
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"While in vitro interactions of USP7 NTD with TRAFs 1 to 6, intracellular USP7 binding to TRAFs 4 and 6, and USP7 deubiquitination of TRAF6 have been reported, biological targeting and deubiquitination of the TRAFs by USP7 have generally not been assessed."
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"Cytoplasmic USP7 binds to and deubiquitinates TRAF6 and IKKgamma, thus terminating TLR mediated NF-kappaB and JNK activation."
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