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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP7 deubiquitinates TRAF6. 3 / 3

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"USP15 negatively regulates NFjB activation by deubiquitinating IjB (Harhaj and Dixit 2011) , while USP7 decreases NFkB signalling by deubiquitinating TRAF6 and IKK (Nanduri et al. 2013 )."

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"While in vitro interactions of USP7 NTD with TRAFs 1 to 6, intracellular USP7 binding to TRAFs 4 and 6, and USP7 deubiquitination of TRAF6 have been reported, biological targeting and deubiquitination of the TRAFs by USP7 have generally not been assessed."

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"Cytoplasmic USP7 binds to and deubiquitinates TRAF6 and IKKgamma, thus terminating TLR mediated NF-kappaB and JNK activation."

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USP7 deubiquitinates TRAF6. 3 / 3

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