IndraLab

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USP7 deubiquitinates TP53. 83 / 83
1 1 | 81
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"This result indicates that ABRO1 specifically facilitates USP7 mediated deubiquitination of p53."
25283148
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"USP7 deubiquitinates several tumour suppressors (p53, PTEN, FOXO and claspin) and E3 ligases (MDM2, Mule and viral proteins ICP0) and therefore regulates important signalling pathways that are involved in tumorigenesis XREF_BIBR XREF_BIBR."
25960197
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"The observation that HAUSP can directly interact with and deubiquitylate both p53 and MDM2 creates a conundrum : how can HAUSP stabilize p53 while at the same time being able to stabilize MDM2, which is primarily responsible for the destruction of p53?"
16402859
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"XREF_BIBR - XREF_BIBR USP7 deubiquitinates and stabilizes not only p53, but also Mdm2, the primary E3 ubiquitin ligase of p53 XREF_BIBR, XREF_BIBR Given that both p53 and Mdm2 are known regulators of the steady-level of Poleta, we speculated that changes in cellular USP7 levels may also modulate Poleta level."
25435364
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"Ubiquitin specific protease 7 (USP7) deubiquitinates p53 and Hdm2 and regulates their stability."
26786098
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"Via these interactions, MLF2 inhibits the binding of USP7 to p53 and antagonizes USP7-mediated deubiquitination of p53, thereby leading to p53 destabilization."
37438558
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"In particular, USP7 deubiquitinates p53 and WASH (part of the Wiskott–Aldrich Syndrome protein family), suggesting its role in disrupting tumor suppression pathways [23]."
32101552
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"USP7, also known as the hepes simplex virus associated ubiquitin specific protease (HAUSP), deubiquitinates both mdm2 and p53, and plays an important role in regulating the level and activity of p53."
20816748
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"In addition, USP7 may deubiquitinate p53 via Mdm2."
28406480
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"The first structure corresponds to USP7 (also known as HAUSP, Herpes associated USP), a DUB that preferentially deubiquitinates MDM2 (Murine Double Minute 2), the ubiquitin ligase for the tumor suppressor p53, as well as p53 itself XREF_BIBR."
19243136
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"As expected, the endogenous USP7 and GMPS complex efficiently deubiquitylated Ub-p53 (lanes 15 and 16)."
15749019
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"Consistent with these results, enforced expression of ABRO1 dramatically facilitated USP7 mediated deubiquitination of p53 (XREF_FIG), whereas knockdown of ABRO1 decreased USP7 mediated p53 deubiquitination (XREF_FIG)."
25283148
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"Review"
28801249
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"HAUSP directly binds to and deubiquitylates p53 both in vivo and in vitro."
16402859
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"For example, USP7 and USP10 bind to and deubiquitylate their substrate p53 to mediate its role for suppression of cell propagation upon cellular stresses by counteracting its degradation ."
31745110
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"We investigated whether USP7 could also deubiquitylate p53, and whether this process, like H2B deubiquitylation, might be GMPS dependent."
15749019
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"The first DUB shown to function in this pathway was USP7, also called Herpes Specific Ubiquitin Specific Protease (HAUSP), which was found to directly deubiquitinate and stabilize p53 [XREF_BIBR]."
21624367
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"HAUSP not only deubiquitinates p53, but also Mdm2."
19450511
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"Another important regulator of p53 function is the Ubiquitin Specific Protease 7, USP7 (OMIM 602519), which de-ubiquitylates p53 and protects it from proteasome mediated degradation."
23412905
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"P53 is then de-ubiquitinated by HAUSP at the mitochondria which enables its interaction with Bcl-2 family members."
19181875
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"In contrast, monoubiquitylation by MDM2 stimulates the nuclear export of p53, which upon arrival at mitochondrial is deubiquitylated by mitochondrial HAUSP, thus generating the apoptotically active non ubiquitylated p53 XREF_BIBR Other post-translational modifications of p53 (such as phosphorylation of C-terminal serines) can stimulate nuclear export and/or mitochondrial association."
19407794
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"HAUSP de-ubiquitinates p53 to rescue it from proteasomal degradation."
20418905
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"For example, USP7 and HAUSP deubiquitinated and stabilized p53, followed by inducing p53 dependent cell growth repression and apoptosis [18]."
19358823
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"USP7, also known as Herpes associated USP (HAUSP), deubiquitinates p53 and Mdm2 and is inhibited by the Epstein-Barr nuclear antigen 1 (EBNA1) protein of Epstein-Barr virus (EBV)."
19489724
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"The inclusion of GMPS and loss of MDM2 makes way for USP7 driven p53 deubiquitylation and stabilization."
24507714
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"Thus, the deubiquitination of p53 by USP7 is blocked, leading to its degradation [XREF_BIBR]."
29160853
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"Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization."
29056421
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"In addition, USP7 may deubiquitinate p53 in trans through an Mdm2 mediated indirect interaction [XREF_BIBR]."
26460617
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"XREF_BIBR USP7 can deubiquitinate various tumor suppressors (p53, PTEN, FOXO, and claspin), E3 ligases (MDM2 and MDMX and viral protein ICP0), as well as chromatin associated proteins (histone H2B, UHRF1, and Tip60); therefore, it regulates important cellular processes involved in the tumorigenesis."
27051296
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"Recently, it was shown that mitochondrial HAUSP can deubiquitinate p53 allowing for interaction with BclXL, 36 however, the abundance of mitochondrial HAUSP needs to be further investigated as HAUSP is mainly localized in the nucleus."
19543236
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"Interestingly, both USP7 and USP10 are involved in regulation of the tumor suppressor protein p53 where USP7 and USP10 cooperatively deubiquitinate p53."
33095475
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"A small molecule inhibitor of USP7 (HBX 41,108) inhibits USP7 mediated deubiquitination of p53 and induces apoptosis in colon carcinoma, suggesting the therapeutic potential in targeting USP7."
28166483
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"Additionally, Mdm2, MdmX and p53 can be deubiquitinated by the HAUSP (herpesvirus associated ubiquitin specific protease) protein."
28690977
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"A number of DUBs can modulate p53 signals : USP7 deubiquitylates both p53 and MDM2, one of the ubiquitin ligases that ubiquitylates p53, thereby stabilizing both proteins."
27516771
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"In unstressed cells, USP7 deubiquitylates both p53 and MDM2 and contributes to a finely balanced state in which p53 is continuously degraded 58."
29657328
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"Different strategies are being employed to achieve this, including Ube1 inhibition to prevent Ub activation, HDM2 inhibition to block p53 polyubiquitination, and USP7 and HAUSP inhibition to promote HDM2 degradation."
23822887
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"It will also be important to discover whether USP10 activity is involved in regulating the ubiquitination status of the mitochondrial fraction of p53, as has been reported for USP7; the deubiquitinati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20144755
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"Another important regulator of p53 is USP7, encoded by the USP7 gene, which deubiquitylates p53 and protects it from proteasome degradation [XREF_BIBR]."
26382048
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"Usp7 directly deubiquitinates and stabilises p53, it is also necessary for p53 stabilisation by the tumour suppressor ING1 [XREF_BIBR]."
25962961
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"Because HAUSP can deubiquitinate both p53 and Mdm2, the dynamic consequences are not straightforward."
15865937
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"While the E3-ligase MDM2 ubiquitinates p53 to induce its proteasomal degradation, HAUSP deubiquitinates P53 and stabilizes the protein."
25610759
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"Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from MDM2 mediated degradation of p53 in response to stress."
26077642
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"USP7 preferentially deubiquitylates the E3 ligase HDM2 and its binding partner HDMX as well as their substrate p53 (Brooks et al., 2007; Cummins and Vogelstein, 2004; Li et al., 2002, 2004; Meulmeeste[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22118674
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"This modification promotes p53 translocation to mitochondria, where p53 is deubiquitinated by herpesvirus-associated ubiquitin-specific protease (HAUSP), and the deubiquitinated protein enhances the mitochondrial outer membrane permeabilization by interacting with Bcl-2 family proteins (BclXL/Bcl2 and Bax) (65)."
36338723
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"Further, in vitro assays have shown that MDM2 may act as a bridge so that deubiquitination of p53 by USP7 can occur in the absence of a direct interaction between the two proteins [XREF_BIBR]."
23151129
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"USP7/HAUSP can deubiquitinate and stabilize both Mdm2 and p53 depending on cellular stress."
| PMC
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"GMPS is not only involved in nucleotide biosynthesis but also modulates the function of USP7 deubiquitination of both H2B and p53, resulting in epigenetic silencing and DNA repair respectively."
25605410
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"Another level of regulation was recently introduced with the discovery of the deubiquitinating enzyme, HAUSP (herpesvirus protein associated cellular factor), which binds and deubiquitinates p53 [59]."
15865930
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"USP7 deubiquitinates both p53 and MDM2, one of the ubiquitin ligases that ubiquitylates p53, thereby stabilizing both proteins [XREF_BIBR, XREF_BIBR]."
29142505
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"It has been reported that Hausp de-ubiquitinates Mdm2 and p53 [XREF_BIBR; XREF_BIBR]."
20153724
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"Mutations in USP7, that deubiquitinates p53 preventing its degradation and enhancing p53 dependent transcription regulation, cell growth repression and apoptosis, 44 were found in four relapse samples."
28157215
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"This differs from the behaviour of HAUSP, which deubiquitinates p53 in addition to Mdm2 and thus protects p53 from Mdm2 mediated degradation."
17290220
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"Second, In Drosophila, GMPS was found to stimulate deubiquitylation of p53 by USP7 and we have not observed this effect with human USP7."
19834552
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"Thus USP7 would be posited to have opposing effects depending on whether it predominantly deubiquitinates and rescues p53 or MDM2."
20073038
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"USP7 is a critical component of this pathway as it deubiquitinates and stabilizes both p53 and MDM2."
24239534
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"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation ."
31745110
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"Selfubiquitination is inhibited during times of nonstress by the deubiquitase HAUSP, an enzyme that specifically interacts with and deubiquitinates both Mdm2 and p53 in a mutually exclusive manner [XREF_BIBR - XREF_BIBR]."
20404858
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"Herpesvirus associated ubiquitin specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53-MDM2 pathway."
16402859
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"USP7 can deubiquitinate and stabilize p53, but interestingly it can also deubiquitinate and stabilize MDM2 indirectly leading to p53 destabilization and its degradation by the proteasome [XREF_BIBR]."
27597804
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"Considering that the interaction among GMPS, USP7 with p53 is required for the deubiquitination and stabilization of p53 [41, 43]."
33742136
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"Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization."
11923872
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"Another example of de-ubiquitinizing enzyme is HAUSP (Herpesvirus associated ubiquitin specific protease), which antagonizes ubiquitination of p53 [XREF_BIBR]."
17488476
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"USP7 can lead to the deubiquitination and stabilization of p53 by inhibiting Mdm2."
27129219
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"The deubiquitinase activity of HAUSP and USP10 exist in different compartments : HAUSP deubiquitinates and stabilizes p53 primarily in the nucleus [XREF_BIBR], whereas USP10 largely deubiquitinates cytoplasmic p53 during homeostasis, although it retains deubiquitinase activity upon translocation to the nucleus following DNA damage [XREF_BIBR]."
20932800
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"Importantly, HAUSP can deubiquitinate MDM2, MDMX, and p53."
25808808
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"The small pool of p53 that either escapes NLS I ubiquitination or is subsequently deubiquitinated by HAUSP interacts with the import machinery, supplying a constant, but low level of nuclear p53 in unstressed cells."
19927155
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"USP7 deubiquitinates Mdm2 and p53, and its overexpression causes Mdm2 and p53 stabilization."
26460617
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"USP7 deubiquitinates both mdm2 (which enhances p53 degradation) and p53 (which inhibits p53 degradation)."
25191222
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"Interestingly, USP7 can deubiquitinate both p53 and its negative regulator HDM2, an E3 ubiquitin ligase responsible for polyubiquitination and subsequent degradation of p53."
30807924
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"Wild-type USP7, but not its catalytically inactive mutant, deubiquitinates and stabilizes p53 [XREF_BIBR] (XREF_FIG)."
27844253
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"USP7 interacts with and deubiquitinates p53, thereby stabilizing and protecting it from Mdm2 mediated degradation [XREF_BIBR]."
18687060
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"Recent studies have shown that the ubiquitination reaction can also be reversed by Herpes virus associated ubiquitin specific protease (HAUSP), which deubiquitinates p53 both in vitro and in vivo."
20514355
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"USP10 translocates to the nucleus, aiding deubiquitination of p53 by USP7."
33095475
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"Based on the results showing association of ABRO1, p53 and USP7, we presumed that ABRO1 might promote interaction between USP7 and p53, and regulate USP7 dependent deubiquitination of p53."
25283148
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"USP7 alone was able to mediate deubiquitylation of p53, as revealed by the decrease of Ub-p53 and the concomitant increase of free p53."
15749019
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"Therefore, while USP7 targets p53 in the nucleus, USP10 deubiquitinates cytoplasmic p53 and upon genotoxic stress it translocates to the nucleus to activate p53."
21480003
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"The same DUB can target proteins from the same pathway that exert opposing effects, for example Usp7 can deubiquitinate both p53 and its E3 ligase MDM2 depending on the circumstances."
25962961
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"One of the most well-known substrate of USP7 is p53, and deubiquitination of p53 by USP7 is critical for its stabilization [XREF_BIBR], indicating its function in regulating tumor development."
29574466
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"Several studies have demonstrated that HAUSP also deubiquitinates and elongates the half-life of Mdm2 as well as p53, and that these three proteins can form a complex XREF_BIBR XREF_BIBR."
26238070
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"Hausp counteracts the destabilizing effect of mdm2 by direct deubiquitination of p53."
16082221
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"USP7 can deubiquitylate p53, but also this activity is strongly stimulated by its association with GMPS."
15749019
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"HAUSP (also termed as USP7) deubiquitinates p53, and is therefore considered to be an important positive regulator of p53 stabilization."
24756567
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"An important regulator of p53 function is the herpesvirus associated ubiquitin specific protease, HAUSP or USP7, which deubiquitylates p53 and protects it from proteasome mediated degradation XREF_BIBR."
20885946