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USP7 deubiquitinates TP53. 131 / 133
1 1 | 131
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"Abraxas brother 1 (ABRO1), a component of the BRCC36-containing isopeptidase complex (BRISC), stabilises p53 by promoting its interaction with USP7 to reduce p53 ubiquitination (166)."
36969062
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"USP7 deubiquitinates Mdm2 and p53, and its overexpression causes Mdm2 and p53 stabilization."
26460617
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"Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization."
29056421
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"It has been reported that the expression level of USP7 is elevated in several types of tumor cells.31 32 Overexpression of USP7 causes deubiquitination of HDM2 and degradation of P53, which can promote tumor progression."
40104064
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"HAUSP interacted with and deubiquitinated p53, leading to increased p53 levels."
15916963
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"Another example of de-ubiquitinizing enzyme is HAUSP (Herpesvirus associated ubiquitin specific protease), which antagonizes ubiquitination of p53 [XREF_BIBR]."
17488476
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"One of the most well-known substrate of USP7 is p53, and deubiquitination of p53 by USP7 is critical for its stabilization [XREF_BIBR], indicating its function in regulating tumor development."
29574466
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"Some well-established examples include histone deubiquitination by Ubp8 (24), p53 deubiquitination by both Usp7 and Usp10 (25, 26), free K48-linked ubiquitin-chain disassembly by Ubp14 (27), and removal of K63-linked ubiquitin chain from TRAF6 by A20 (28, 29)."
39798877
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"The observation that HAUSP can directly interact with and deubiquitylate both p53 and MDM2 creates a conundrum : how can HAUSP stabilize p53 while at the same time being able to stabilize MDM2, which is primarily responsible for the destruction of p53?"
16402859
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"USP7 deubiquitinates several tumour suppressors (p53, PTEN, FOXO and claspin) and E3 ligases (MDM2, Mule and viral proteins ICP0) and therefore regulates important signalling pathways that are involved in tumorigenesis XREF_BIBR XREF_BIBR."
25960197
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"Herpesvirus associated ubiquitin specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53-MDM2 pathway."
16402859
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"In response to oncogenic insults, HAUSP deubiquitinates p53 and protects p53 from Mdm2-mediated ubiquitylation and degradation."
25912924
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"HAUSP directly binds to and deubiquitylates p53 both in vivo and in vitro."
16402859
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"Although USP7 also de-ubiquitylates p53, it preferentially de-ubiquitylates Mdm2 because of its higher affinity for the latter substrate ( Hu et al., 2006 )."
18203645
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"Interfering with the binding event between PARC and p53 may have several effects, such as restored p53 de-ubiquitylation by USP7 and hence prevention of proteasomal degradation, restored p53 shuttling[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18203645
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"Usp7 directly deubiquitinates and stabilises p53, it is also necessary for p53 stabilisation by the tumour suppressor ING1 [XREF_BIBR]."
25962961
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"USP7 deubiquitinates MDM2, an E3 ligase of p53, and in turn destabilizes p53 (Colland et al., 2009)."
30486612
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"Wild-type USP7, but not its catalytically inactive mutant, deubiquitinates and stabilizes p53 [XREF_BIBR] (XREF_FIG)."
27844253
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"USP7 binds to and directly deubiquitinates p53 and inhibits its degradation."
36624687
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"Via these interactions, MLF2 inhibits the binding of USP7 to p53 and antagonizes USP7-mediated deubiquitination of p53, thereby leading to p53 destabilization."
37438558
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"This disassociation attenuates USP7‐mediated p53 deubiquitination and causes p53 destabilization."
37438558
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"Another level of regulation was recently introduced with the discovery of the deubiquitinating enzyme, HAUSP (herpesvirus protein associated cellular factor), which binds and deubiquitinates p53 [59]."
15865930
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"A number of DUBs can modulate p53 signals : USP7 deubiquitylates both p53 and MDM2, one of the ubiquitin ligases that ubiquitylates p53, thereby stabilizing both proteins."
27516771
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"Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization."
11923872
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"Research has shown [168] that EBNA-1 is able to interact with herpesvirus-associated ubiquitin-specific protease (HAUSP)/USP7, an enzyme that deubiquitinates and stabilizes p53, promoting p53-mediated apoptotic events."
35806271
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"The best-characterized of these enzymes is USP7, a nuclear DUB that deubiquitylates both p53 and MDM2 [102] ."
24704338
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"In contrast, USP7 act as a tumor suppressor by deubiquitinating and stabilizing p53, which induce apoptosis and inhibit cell growth."
35884607
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"XREF_BIBR - XREF_BIBR USP7 deubiquitinates and stabilizes not only p53, but also Mdm2, the primary E3 ubiquitin ligase of p53 XREF_BIBR, XREF_BIBR Given that both p53 and Mdm2 are known regulators of the steady-level of Poleta, we speculated that changes in cellular USP7 levels may also modulate Poleta level."
25435364
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"It has been reported that Hausp de-ubiquitinates Mdm2 and p53 [XREF_BIBR; XREF_BIBR]."
20153724
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"Additionally, Mdm2, MdmX and p53 can be deubiquitinated by the HAUSP (herpesvirus associated ubiquitin specific protease) protein."
28690977
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"USP7 also can deubiquitinate Mdm2, a p53 chaperone molecule and inhibitor, thus inhibiting its degradation (Cummins et al., 2004; Xia et al., 2021)."
37251574
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"When P53 is deubiquitinated by HAUSP, P53 can be acetylated at four well-known lysines (K120, K370, K373, and K382) by CBP and P300, leading to the transactivation of various P53 transcriptional targets.27,28 Thus, we investigated whether SIRT1 deacetylates P53 at these lysines."
31576168
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"Ubiquitin specific protease 7 (USP7) deubiquitinates p53 and Hdm2 and regulates their stability."
26786098
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"This modification promotes p53 translocation to mitochondria, where p53 is deubiquitinated by herpesvirus-associated ubiquitin-specific protease (HAUSP), and the deubiquitinated protein enhances the mitochondrial outer membrane permeabilization by interacting with Bcl-2 family proteins (BclXL/Bcl2 and Bax) (65)."
36338723
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"Interestingly, USP7 deubiquitylated p53 through MDM2 without direct p53 binding (41)."
34425107
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"P53 is then de-ubiquitinated by HAUSP at the mitochondria which enables its interaction with Bcl-2 family members."
19181875
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"Our research not only explored and confirmed that USP7 significantly affected the radiotherapy of LSCC, but also revealed that USP7′s effects on radio-sensitivity depended on the mutation status of p53.It is currently well known that USP7, one of the most studied deubiquitinating enzymes, can deubiquitinate p53 and activate the p53 signaling."
35696794
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"HAUSP de-ubiquitinates p53 to rescue it from proteasomal degradation."
20418905
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"For USP7 to deubiquitylate and stabilize p53 it requires GMPS interaction ( Fig. 1 B)."
33508433
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"In the current study, we present evidence showing that MLF2 destabilizes p53 by attenuating USP7‐mediated deubiquitination of p53."
37438558
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"USP7 deubiquitinates both p53 and MDM2, one of the ubiquitin ligases that ubiquitylates p53, thereby stabilizing both proteins [XREF_BIBR, XREF_BIBR]."
29142505
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"It has been shown that USP7 deubiquitinates p53, leading to p53 stabilization ."
36207426
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"XREF_BIBR USP7 can deubiquitinate various tumor suppressors (p53, PTEN, FOXO, and claspin), E3 ligases (MDM2 and MDMX and viral protein ICP0), as well as chromatin associated proteins (histone H2B, UHRF1, and Tip60); therefore, it regulates important cellular processes involved in the tumorigenesis."
27051296
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"Several studies have demonstrated that HAUSP also deubiquitinates and elongates the half-life of Mdm2 as well as p53, and that these three proteins can form a complex XREF_BIBR XREF_BIBR."
26238070
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"HAUSP (also termed as USP7) deubiquitinates p53, and is therefore considered to be an important positive regulator of p53 stabilization."
24756567
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"Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization."
16845885
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"Moreover, deubiquitination of either p53 or Mdm2 by HAUSP is apparently a critical event in these dynamic processes ( Li et al., 2004; Cummins et al., 2004 ), and additional cellular factors are neces[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15989956
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"Herpesvirus-associated ubiquitin-specific protease (HAUSP) interacts with and stabilizes p53 by deubiquitinating p53 [112]."
38132337
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"Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from MDM2 mediated degradation of p53 in response to stress."
26077642
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"Selfubiquitination is inhibited during times of nonstress by the deubiquitase HAUSP, an enzyme that specifically interacts with and deubiquitinates both Mdm2 and p53 in a mutually exclusive manner [XREF_BIBR - XREF_BIBR]."
20404858
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"The same DUB can target proteins from the same pathway that exert opposing effects, for example Usp7 can deubiquitinate both p53 and its E3 ligase MDM2 depending on the circumstances."
25962961
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"In addition, USP7 may deubiquitinate p53 via Mdm2."
28406480
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"Upon arrival at the mitochondria, p53 is deubiquitinated by mitochondrial HAUSP, leading to apoptosis [295]."
38132337
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"Different strategies are being employed to achieve this, including Ube1 inhibition to prevent Ub activation, HDM2 inhibition to block p53 polyubiquitination, and USP7 and HAUSP inhibition to promote HDM2 degradation."
23822887
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"Importantly, HAUSP can deubiquitinate MDM2, MDMX, and p53."
25808808
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"USP7 plays a dual role in p53 regulation and may deubiquitylate either p53 or its negative regulator, MDM2 (Cummins et al. 2004; Li et al. 2002, 2004)."
27881599
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"Considering that the interaction among GMPS, USP7 with p53 is required for the deubiquitination and stabilization of p53 [41, 43]."
33742136
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"Under stress conditions, USP7 preferentially deubiquitinates and stabilizes p53, allowing for the upregulation of downstream p53-targets such as CDK inhibitor 1 (p21 ) and the induction of cell cycle arrest or apoptosis [43]."
37607592
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"USP7 is a critical component of this pathway as it deubiquitinates and stabilizes both p53 and MDM2."
24239534
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"Recently, it was shown that mitochondrial HAUSP can deubiquitinate p53 allowing for interaction with BclXL, 36 however, the abundance of mitochondrial HAUSP needs to be further investigated as HAUSP is mainly localized in the nucleus."
19543236
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"HAUSP not only deubiquitinates p53, but also Mdm2."
19450511
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"In particular, USP7 deubiquitinates p53 and WASH (part of the Wiskott–Aldrich Syndrome protein family), suggesting its role in disrupting tumor suppression pathways [23]."
32101552
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"USP7 inhibits the ubiquitination of p53, thereby mediating cellular senescence."
40133964
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"We investigated whether USP7 could also deubiquitylate p53, and whether this process, like H2B deubiquitylation, might be GMPS dependent."
15749019
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"USP7 alone was able to mediate deubiquitylation of p53, as revealed by the decrease of Ub-p53 and the concomitant increase of free p53."
15749019
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"As expected, the endogenous USP7 and GMPS complex efficiently deubiquitylated Ub-p53 (lanes 15 and 16)."
15749019
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"USP7 can deubiquitylate p53, but also this activity is strongly stimulated by its association with GMPS."
15749019
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"Ubiquitin-specific peptidase 7 (USP7) is also a p53 regulatory factor, which is able to deubiquitinate and stabilize p53 [22]."
36613989
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"USP7 interacts with and deubiquitinates p53, thereby stabilizing and protecting it from Mdm2 mediated degradation [XREF_BIBR]."
18687060
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"17 , 18 Originally, ectopic overexpression studies revealed that USP7 can directly bind to and deubiquitinate p53, leading to its stabilization."
36952348
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"Thus USP7 would be posited to have opposing effects depending on whether it predominantly deubiquitinates and rescues p53 or MDM2."
20073038
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"The inclusion of GMPS and loss of MDM2 makes way for USP7 driven p53 deubiquitylation and stabilization."
24507714
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"Other studies have demonstrated that changes in USP7 protein expression can modulate colon carcinoma growth and sensitivity to apoptosis in vivo via the stabilization of p53, due to USP7-mediated deubiquitination of p53 proteins [26,27,28], leading to high levels of p53 and restoring the sensitivity to apoptosis by irradiation [29]."
37762082
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"USP7 deubiquitinates both mdm2 (which enhances p53 degradation) and p53 (which inhibits p53 degradation)."
25191222
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"The first DUB shown to function in this pathway was USP7, also called Herpes Specific Ubiquitin Specific Protease (HAUSP), which was found to directly deubiquitinate and stabilize p53 [XREF_BIBR]."
21624367
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"Recent studies have shown that the ubiquitination reaction can also be reversed by Herpes virus associated ubiquitin specific protease (HAUSP), which deubiquitinates p53 both in vitro and in vivo."
20514355
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"The first structure corresponds to USP7 (also known as HAUSP, Herpes associated USP), a DUB that preferentially deubiquitinates MDM2 (Murine Double Minute 2), the ubiquitin ligase for the tumor suppressor p53, as well as p53 itself XREF_BIBR."
19243136
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"Knockdown of USP7 enhanced the ubiquitination of p53 and led to decreased levels of p53 and TFR1, reducing myocardial cell I/R injury and ferroptosis [94]."
39799367
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"Interestingly, both USP7 and USP10 are involved in regulation of the tumor suppressor protein p53 where USP7 and USP10 cooperatively deubiquitinate p53."
33095475
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"For example, USP7 and USP10 bind to and deubiquitylate their substrate p53 to mediate its role for suppression of cell propagation upon cellular stresses by counteracting its degradation ."
31745110
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"USP10 translocates to the nucleus, aiding deubiquitination of p53 by USP7."
33095475
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"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation ."
31745110
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"The small pool of p53 that either escapes NLS I ubiquitination or is subsequently deubiquitinated by HAUSP interacts with the import machinery, supplying a constant, but low level of nuclear p53 in unstressed cells."
19927155
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"USP7 preferentially deubiquitylates the E3 ligase HDM2 and its binding partner HDMX as well as their substrate p53 (Brooks et al., 2007; Cummins and Vogelstein, 2004; Li et al., 2002, 2004; Meulmeeste[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22118674
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"It will also be important to discover whether USP10 activity is involved in regulating the ubiquitination status of the mitochondrial fraction of p53, as has been reported for USP7; the deubiquitinati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20144755
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"The deubiquitinase activity of HAUSP and USP10 exist in different compartments : HAUSP deubiquitinates and stabilizes p53 primarily in the nucleus [XREF_BIBR], whereas USP10 largely deubiquitinates cytoplasmic p53 during homeostasis, although it retains deubiquitinase activity upon translocation to the nucleus following DNA damage [XREF_BIBR]."
20932800
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"Because HAUSP can deubiquitinate both p53 and Mdm2, the dynamic consequences are not straightforward."
15865937
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"A small molecule inhibitor of USP7 (HBX 41,108) inhibits USP7 mediated deubiquitination of p53 and induces apoptosis in colon carcinoma, suggesting the therapeutic potential in targeting USP7."
28166483
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"GMPS is not only involved in nucleotide biosynthesis but also modulates the function of USP7 deubiquitination of both H2B and p53, resulting in epigenetic silencing and DNA repair respectively."
25605410
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"While the E3-ligase MDM2 ubiquitinates p53 to induce its proteasomal degradation, HAUSP deubiquitinates P53 and stabilizes the protein."
25610759
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"USP7 counteracts the effects of Mdm2 auto-ubiquitination to stabilize Mdm2 and promote Mdm2-dependent ubiquitination and consequent degradation of p53."
39862434
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"An important regulator of p53 function is the herpesvirus associated ubiquitin specific protease, HAUSP or USP7, which deubiquitylates p53 and protects it from proteasome mediated degradation XREF_BIBR."
20885946
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"Therefore, while USP7 targets p53 in the nucleus, USP10 deubiquitinates cytoplasmic p53 and upon genotoxic stress it translocates to the nucleus to activate p53."
21480003
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"In contrast, monoubiquitylation by MDM2 stimulates the nuclear export of p53, which upon arrival at mitochondrial is deubiquitylated by mitochondrial HAUSP, thus generating the apoptotically active non ubiquitylated p53 XREF_BIBR Other post-translational modifications of p53 (such as phosphorylation of C-terminal serines) can stimulate nuclear export and/or mitochondrial association."
19407794
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"USP7, also known as Herpes associated USP (HAUSP), deubiquitinates p53 and Mdm2 and is inhibited by the Epstein-Barr nuclear antigen 1 (EBNA1) protein of Epstein-Barr virus (EBV)."
19489724
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"Identification of the in vivo association among RORα, p53, and HAUSP allowed us to hypothesize that RORα might affect p53 stability by regulating the p53-HAUSP binding and the HAUSP-dependent deubiqui[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22152482
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"3 USP7 was shown to catalyze the deubiquitination of p53 both in vitro and in vivo ."
20713061
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"In unstressed cells, USP7 deubiquitylates both p53 and MDM2 and contributes to a finely balanced state in which p53 is continuously degraded 58."
29657328
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"Consistent with these results, enforced expression of ABRO1 dramatically facilitated USP7 mediated deubiquitination of p53 (XREF_FIG), whereas knockdown of ABRO1 decreased USP7 mediated p53 deubiquitination (XREF_FIG)."
25283148
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"Akin to IMPDH, GMPS can also repress transcription by forming a complex with nuclear ubiquitin-specific protease 7 (USP7), which deubiquitylates p53 and histone H2B to epigenetically silence downstrea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33406403
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"For USP7, even though the N-terminal TRAF-like domain does bind to mdm2 and p53, it is not essential for USP7’s deubiquitinating activity towards mdm2 and p53."
20816748
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"Second, In Drosophila, GMPS was found to stimulate deubiquitylation of p53 by USP7 and we have not observed this effect with human USP7."
19834552
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"Another important regulator of p53 is USP7, encoded by the USP7 gene, which deubiquitylates p53 and protects it from proteasome degradation [XREF_BIBR]."
26382048
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"Based on the results showing association of ABRO1, p53 and USP7, we presumed that ABRO1 might promote interaction between USP7 and p53, and regulate USP7 dependent deubiquitination of p53."
25283148
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"This result indicates that ABRO1 specifically facilitates USP7 mediated deubiquitination of p53."
25283148
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"USP7 directly deubiquitylates and stabilizes the p53 protein, which is induced by DNA damage ( Li et al., 2002 )."
32966862
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"The expression of USP7/HAUSP prevents p53 ubiquitination from Mdm2 as a p53-specific E3 ligase and increases the p53 protein stability [25]."
| PMC
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"USP7 strongly stabilizes p53 by deubiquitinating p53 both in vitro and in vivo [99], it also binds and deubiquitinates MDM2 in a p53-independent manner and decreasing p53 levels in normal cells [20, 99, 100]."
40102846
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"HAUSP can deubiquitinate p53 both in vivo and in vitro."
15571815
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"In support of the idea that p53 deubiquitination by HAUSP is physiologically relevant, the overproduced UBP can strongly inhibit growth of human carcinoma lung cells expressing wild-type p53, but this[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15571815
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"In addition, inhibition or knockdown of USP7 enhanced the ubiquitination of p53 along with the decreased levels of p53, which led to down-regulation of TFR1 [55]."
36443440
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"USP7/HAUSP can deubiquitinate and stabilize both Mdm2 and p53 depending on cellular stress."
| PMC
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"Whether rates of p53 deubiquitination by HAUSP can be regulated is not known, but it is intriguing that the herpes simplex virus protein ICP0 binds HAUSP and may control HAUSP activity toward particul[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15571815
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"This differs from the behaviour of HAUSP, which deubiquitinates p53 in addition to Mdm2 and thus protects p53 from Mdm2 mediated degradation."
17290220
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"Mutations in USP7, that deubiquitinates p53 preventing its degradation and enhancing p53 dependent transcription regulation, cell growth repression and apoptosis, 44 were found in four relapse samples."
28157215
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"Another study by Peng et al. demonstrated that USP7 promotes ferroptosis in MIRI by deubiquitinating and stabilizing p53, which in turn regulates transferrin receptor 1 (TfR1) levels in I/R-treated rat hearts [20]."
40102846
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"Therefore, deubiquitination of p53 by USP7 or USP10 are indispensible for p53 transcription and transcription-independent cell death [20,22] ."
20226183
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"Further, in vitro assays have shown that MDM2 may act as a bridge so that deubiquitination of p53 by USP7 can occur in the absence of a direct interaction between the two proteins [XREF_BIBR]."
23151129
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"USP7 deubiquitinate p53 and modulate the p53-Mdm2 pathway [58,59,60]."
35884607
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"Thus, the deubiquitination of p53 by USP7 is blocked, leading to its degradation [XREF_BIBR]."
29160853
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"For example, USP7 and HAUSP deubiquitinated and stabilized p53, followed by inducing p53 dependent cell growth repression and apoptosis [18]."
19358823
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"23 , 24 On the other hand, USP7 can also deubiquitinate and stabilize p53."
37438558
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"Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization."
19929178
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"Another important regulator of p53 function is the Ubiquitin Specific Protease 7, USP7 (OMIM 602519), which de-ubiquitylates p53 and protects it from proteasome mediated degradation."
23412905
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"USP7 can lead to the deubiquitination and stabilization of p53 by inhibiting Mdm2."
27129219
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"Interestingly, USP7 deubiquitinated MDM2 and its target p53, likewise, our data indicated that UBP12/13 interact with CRY2 and COP1 simultaneously."
35700731
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"In addition, USP7 may deubiquitinate p53 in trans through an Mdm2 mediated indirect interaction [XREF_BIBR]."
26460617
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"Interestingly, USP7 can deubiquitinate both p53 and its negative regulator HDM2, an E3 ubiquitin ligase responsible for polyubiquitination and subsequent degradation of p53."
30807924
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"Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization."
29616860
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"USP7 can deubiquitinate and stabilize p53, but interestingly it can also deubiquitinate and stabilize MDM2 indirectly leading to p53 destabilization and its degradation by the proteasome [XREF_BIBR]."
27597804
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"To investigate whether Hdmx can be directly deubiquitinated by HAUSP, we used an in vitro system in which deubiquitination of p53 by HAUSP was shown ( Canning et al., 2004 )."
15916963