IndraLab
Statements
"overexpression or depletion of USP37 caused an increase or decrease of PLZF/<span class="match term1">RARA</span> protein half-life, correlating with down- or upregulation of PLZF/<span class="match term1">RARA</span> poly-ubiquitination, respectively. By PLZF/<span class="match term1">RARA</span>-transduced primary mouse hematopoietic progenitor cells, we demonstrated that Usp37 knockdown alleviated PLZF/<span class="match term1">RARA</span>-mediated target gene suppression and cell transformation potential"