IndraLab

Statements

USP7 deubiquitinates SUV39H1. 2 / 2
| 2
reach
"Collectively, these results indicate that shared physical interactions of USP7 and SUV39H1 with MDM2 are required for either for USP7 to deubiquitinate SUV39H1 or for MDM2 to ubiquitinate SUV39H1; both resulting in enhanced SUV39H1 stability."
26971997
reach
"In the absence of p53, USP7 deubiquitinates SUV39H1 providing protection from MDM2 ubiquitination and USP7, MDM2 and SUV39H1 form a DNA independent trimeric complex.35Finally, the role of US7 in regulation of epigenetic regulators is evidenced by the interaction of USP7 with LSD1."
35005106