IndraLab

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USP7 deubiquitinates CLSPN. 5 / 5
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"Because extracts from mitotic cells readily support ubiquitylation of Claspin in a betaTrCP dependent fashion, we used such an approach to test whether USP7 directly deubiquitylates Claspin in vitro."
19124652
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"In contrast, little if any effect on Claspin stability was evident in cells expressing USP7 CI (XREF_FIG), which supports the idea that Claspin is deubiquitylated by USP7."
19124652
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"In such experiments, USP7 CI interacted more strongly with endogenous Claspin than did WT USP7 (XREF_FIG), which is consistent with a substrate trapping mechanism in which an inability of inactive USP7 to deubiquitylate Claspin would manifest as a prolonged binding and thus a tighter interaction."
19124652
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"Review"
27775833
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"68 HAUSP deubiquitinates checkpoint kinase Chk1, 69 its activator Claspin, 70 and checkpoint with forkhead and RING finger domain protein (Chfr)."
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