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USP7 deubiquitinates UHRF1. 6 / 7
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"Notably, a slower migrating UHRF1 species was selectively observed in HDFs treated with AD‐04 (Figure 3D); this suggested mono‐ubiquitylation of UHRF1 in response to USP7 inhibition."
38602256
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"In the hypermethylated region of the DMRs, we observed that a deubiquitinating enzyme, USP7, is enriched with methylation information and it has been shown that USP7 can regulate overall DNA methylation by deubiquitinating DNA methyltransferase-1 and Uhrf1 (58, 59)."
38097189
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"Indeed, USP7 mediates deubiquitylation of UHRF1, preventing its proteasomal degradation."
31492965
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"In a pivotal counterbalance, USP7 mediates the deubiquitination of both UHRF1 and DNMT1, rescuing them from proteasomal degradation, thus ensuring their stability and function within the cell [44]."
39051184
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"Both UHRF1 and DNMT1 are deubiquitinated and stabilized by USP7 [XREF_BIBR, XREF_BIBR], while UHRF1 is the negative regulator of DNMT1 [XREF_BIBR]."
26046769
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"The deubiquitinase USP7 inhibits the polyubiquitination of UHRF1 by recognizing the phosphorylation at UHRF1-S652."
38725075