IndraLab

Statements

USP7 deubiquitinates FOXO. 5 / 5
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"This process may be reversed by the deubiquitination of FOXO proteins mediated by HAUSP and USP7."
21238503
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"Deubiquitination of FOXO requires the deubiquitinating enzyme USP7 and HAUSP (herpesvirus associated ubiquitin specific protease), which interacts with and deubiquitinates FOXO in response to oxidative stress."
16964248
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"In the nucleus, USP7 deubiquitinates FOXO proteins, and moreover, PP2A could dephosphorylate FOXO, presumably not only at the Akt phosphorylation sites but also at the MST1-mediated site."
18951090
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"Under oxidative stress, Usp7 deubiquitinates Foxo to promote its interaction with Yki, thereby activating the expression of proliferation suppressors."
39106181
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"Deubiquitination of Foxo is mediated by the deubiquitinating enzyme USP7."
21443461